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The phosphate makes a difference: cellular functions of NADP
Open accessAbstract
Recent research has unraveled a number of unexpected functions of the pyridine nucleotides. In this review, we will highlight the variety of known physiological roles of NADP. In its reduced form (NADPH), this molecule represents a universal electron donor, not only to drive biosynthetic pathways. Perhaps even more importantly, NADPH is the unique provider of reducing equivalents to maintain or regenerate the cellular detoxifying and antioxidative defense systems. The roles of NADPH in redox sensing and as substrate for NADPH oxidases to generate reactive oxygen species further extend its scope of functions. NADP(+), on the other hand, has acquired signaling functions. Its conversion to second messengers in calcium signaling may have critical impact on important cellular processes. The generation of NADP by NAD kinases is a key determinant of the cellular NADP concentration. The regulation of these enzymes may, therefore, be critical to feed the diversity of NADP-dependent processes adequately. The increasing recognition of the multiple roles of NADP has thus led to exciting new insights in this expanding field.
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Cites
The redox state of free nicotinamide-adenine dinucleotide phosphate in the cytoplasm of rat liver
Veech, R. L., Eggleston, L. V., & Krebs, H. A. (1969) · Biochemical Journal · doi:10.1042/bj1150609a · Cited by 563
Jo, S.-H., Son, M.-K., Koh, H.-J., Lee, S.-M., Song, I.-H., Kim, Y.-O., Lee, Y.-S., Jeong, K.-S., Kim, W. B., Park, J.-W., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010120200 · Cited by 536
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Axonal energy metabolism, and the effects in aging and neurodegenerative diseases
Yang, S., Park, J. H., & Lu, H.-C. (2023) · Molecular Neurodegeneration · doi:10.1186/s13024-023-00634-3 · Cited by 94
“It is yet to be determined whether NADP+ synthesis by NADK is required to suppress SARM1 activity and if SARM1 also mediated NADP+ degradation to exacerbate oxidative stress [324].”
BackgroundSite-Mapping of In Vitro S-nitrosation in Cardiac Mitochondria: Implications for Cardioprotection
Murray, C. I., Kane, L. A., Uhrigshardt, H., Wang, S.-B., & Van Eyk, J. E. (2011) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m110.004721 · Cited by 63
Metadata
- Authors
- Agledal, L., Niere, M., & Ziegler, M.
- Venue
- Redox Report
- Publisher
- Informa UK Limited
- Published
- 2010-02
- Volume
- 15
- Issue
- 1
- Pages
- 2-10
- ISSN
- 1351-0002 (ISSN-L)
- 1743-2928
- OpenAlex
- W2015019014
- Cited by
- 208
- References
- 2
- FWCI
- 1.30
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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