Axonal energy metabolism, and the effects in aging and neurodegenerative diseases

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Synaptic Energy Use and Supply

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NAD ⁺ in aging, metabolism, and neurodegeneration

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Lactate in the brain: from metabolic end-product to signalling molecule

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A Cellular Perspective on Brain Energy Metabolism and Functional Imaging

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Oligodendrocyte heterogeneity in the mouse juvenile and adult central nervous system

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Normal aging induces A1-like astrocyte reactivity

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Axonopathy and Transport Deficits Early in the Pathogenesis of Alzheimer’s Disease

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The axonal transport of mitochondria

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The hubs of the human connectome are generally implicated in the anatomy of brain disorders

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Microglial brain region-dependent diversity and selective regional sensitivities to aging

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Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer’s disease

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Saturated Reconstruction of a Volume of Neocortex

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Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing

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Large-scale proteomic analysis of Alzheimer’s disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation

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Nutrient-Sensitive Mitochondrial NAD+ Levels Dictate Cell Survival

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Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease

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Brain Glucose Metabolism: Integration of Energetics with Function

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Cell type- and brain region-resolved mouse brain proteome

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Polydendrocytes (NG2 cells): multifunctional cells with lineage plasticity

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The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C-Cdh1

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A Single-Cell Transcriptome Atlas of the Aging Drosophila Brain

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Activity-driven local ATP synthesis is required for synaptic function

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NAD+ in Brain Aging and Neurodegenerative Disorders

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The case for rejecting the amyloid cascade hypothesis

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Single-cell transcriptomic profiling of the aging mouse brain

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White matter changes in Alzheimer’s disease: A focus on myelin and oligodendrocytes

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Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model

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The aging astrocyte transcriptome from multiple regions of the mouse brain.

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The Redox Code

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Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer’s Disease Progression

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Synaptic degeneration in Alzheimer disease

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Endogenous Nmnat2 Is an Essential Survival Factor for Maintenance of Healthy Axons

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Lifelong cortical myelin plasticity and age-related degeneration in the live mammalian brain

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Neuronal Stimulation Triggers Neuronal Glycolysis and Not Lactate Uptake

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The Role of Environmental Exposures in Neurodegeneration and Neurodegenerative Diseases

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Vesicular Glycolysis Provides On-Board Energy for Fast Axonal Transport

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The axon initial segment and the maintenance of neuronal polarity

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Bidirectional cargo transport: moving beyond tug of war

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In Situ Activatable Hydrogen‐Bonded Organic Framework‐Based Nanozyme as NADH Peroxidase Mimic Restoring Homeostasis for Treatment of Alzheimer's Disease

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MİTOKONDRİYAL YAŞLANMA

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Peripheral nervous system involvement in Parkinson’s disease: Peripheral neuropathy, neuromuscular junction dysfunction, and clinical implications

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Early disruptions in brain capillary blood flow control in a mouse model of Alzheimer’s disease

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Thalamic Neuron Resilience during Osmotic Demyelination Syndrome (ODS) Is Revealed by Primary Cilium Outgrowth and ADP-ribosylation factor-like protein 13B Labeling in Axon Initial Segment

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Application of proteomics in brain's aging research

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Unique transcriptomic alterations in 5XFAD;PS19 mouse model identify glial lipid dysregulation and coordinated microglial–oligodendrocyte responses

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Zaky, M. Y., & Lamloum, N. S. (2024) · Nutritional neurosciences · doi:10.1007/978-981-97-6341-2_3

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Absolute quantification of brain deuterium metabolic imaging in healthy volunteers and glioblastoma patients at 7TPreprint

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Additional file 1 of Pathological characteristics of axons and alterations of proteomic and lipidomic profiles in midbrain dopaminergic neurodegeneration induced by WDR45-deficiency

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Additional file 2 of Pathological characteristics of axons and alterations of proteomic and lipidomic profiles in midbrain dopaminergic neurodegeneration induced by WDR45-deficiency

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Additional file 3 of Pathological characteristics of axons and alterations of proteomic and lipidomic profiles in midbrain dopaminergic neurodegeneration induced by WDR45-deficiency

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Extracellular Vesicles Carrying the Tenascin-C Protein Participate in Glucose Metabolism in Neurodegenerative Injury Via Inhibiting Pi3k/Akt PathwayPreprint

Shao, W., Liu, X., Chen, L., Zhu, X., Wu, Q., Bu, C., Zheng, F., Yu, G., Hu, H., Guo, Z., et al. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5392128

RNA-Seq reveals flight-induced changes in cerebellar transcriptomic profiles of racing pigeons

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Phenotypic Age Acceleration for Stratification of Mortality Risk and Survival Benefits in major chronic disease Populations: A Prospective Cohort StudyPreprint

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Mechanistic insights into glufosinate-ammonium (GLA)-Induced brain injury revealed by LC-MS/MS-based metabolomics

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Age-related changes to brain energetics revealed by PET/MRI imaging

Bevington, C. W. J., Dhaliwal, S., McKenzie, J., Stoessl, A. J., & Sossi, V. (2026) · NeuroImage Clinical · doi:10.1016/j.nicl.2026.104014

Nicotinamide nucleotide transhydrogenase deficiency impairs neuronal function via energy metabolism dysregulation in Alzheimer's disease

Wan, X., Lu, W., Liu, S., Zhao, Y., Hu, J., Ding, X., Gu, P., Zou, Y., Jiang, B., & Yang, Y. (2026) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2026.05.341

Evaluation of retinal nerve fiber layer and choroidal thickness in patients with methamphetamine use disorder

Muhammad, H., Yasin, M. A. B. M., Jaafar, J., Hou, L. J., & Hitam, W. H. W. (2026) · Taiwan Journal of Ophthalmology · doi:10.4103/tjo.tjo-d-25-00165

Volume electron microscopy in axon regeneration research: insights into mitochondria, endoplasmic reticulum, and membrane contacts

Tamada, H. (2026) · Frontiers in Neural Circuits · doi:10.3389/fncir.2026.1870424

Synaptic dysfunction as a major driver in Alzheimer's disease: Beyond the amyloid paradigm

Mierzwa, N., & Wężyk, M. (2026) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2026.106858

A systematic review and meta-analysis of OCT-based ophthalmic changes in amyotrophic lateral sclerosis

Ahsan, A., Ou, J., Majumder, P., Chiang, Y. H., Huang, J. K., & Huang, C.-C. S. (2026) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2026.579028

Neurons Die Not by One Hit, but by Signaling Convergence

Chauhan, D., Goel, F., & Rajput, M. S. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-06093-3

Mitochondrial Dysfunction as a Driver of Meta-Inflammation in Aging: The Emerging Role of PDK4 in Bioenergetic Reprogramming and Inflammatory Amplification

Chowdhury, M. R., Jeong, G.-H., & Lee, I. (2026) · Cells · doi:10.3390/cells15151404

Neuronal Prps is required for synaptic development and locomotor function in Drosophila melanogaster

Dang, T. N., & Yoshida, H. (2026) · Gene · doi:10.1016/j.gene.2026.150361

Extracellular vesicles carrying the tenascin-C protein participate in glucose metabolism in neurodegenerative injury via inhibiting the AKT/GLUT1 pathway

Liu, X., Chen, L., Zhu, X., Wu, Q., Bu, C., Zheng, F., Yu, G., Hu, H., Guo, Z., Zhou, J., et al. (2026) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2026.112318

Repurposing Antidiabetic Drugs in Neurodegenerative Disorders: From Preclinical Mechanisms to Clinical Evidence

Devi, D., Rani, A., Singh, J., Quasmi, M. N., Jangra, A., & Kumar, D. (2026) · SN Comprehensive Clinical Medicine · doi:10.1007/s42399-026-02731-y

Bone regulates locomotion by sustaining motoneuronal mitochondrial functionPreprint

Romeo-Guitart, D., Tirani, T., Milunov, D., Torres-Juacida, A. K., Lamotte, B., Arenas-Plascencia, C., Durand, S., Nemazanyy, I., Moriceau, S., Saha, S., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.10.07.750453

Macroscopic cerebral energy efficiency corresponds to neuron reorganization in awake and anesthetized mice

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Nutrients and Their Role in Autophagy Regulation.

Wilson, N., Kocak, G., Sarkar, S., Rabanal-Ruiz, Y., & Korolchuk, V. (2026) · Biochemistry · doi:10.1021/acs.biochem.6c00482

Emerging evidence for compromised axonal bioenergetics and axoglial metabolic coupling as drivers of neurodegeneration

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Energy Metabolism Decline in the Aging Brain—Pathogenesis of Neurodegenerative Disorders

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Of axons that struggle to make ends meet: Linking axonal bioenergetic failure to programmed axon degeneration

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Metabolic aspects of neuronal degeneration: From a NAD+ point of view

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Metabolic Vulnerability in the Neurodegenerative Disease Glaucoma

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