The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Trafficking machinery of NKT cells: shared and differential chemokine receptor expression among Vα24+Vβ11+ NKT cell subsets with distinct cytokine-producing capacity
Abstract
Natural killer T (NKT) cells are important regulators of the immune system, but their trafficking machinery, including expression of chemokine receptors, has been poorly defined. Unlike other conventional T-cell populations, we show that most NKT cells express receptors for extralymphoid tissue or inflammation-related chemokines (CCR2, CCR5, and CXCR3), while few NKT cells express lymphoid tissue–homing chemokine receptors (CCR7 and CXCR5). A population with homing potential for lymph nodes (L selectin+ CCR7+) exists only within a small subset of CD4 NKT cells. We show differential expression of chemokine receptors among NKT cell subsets: CCR4 is mainly expressed by a high cytokine (interleukin-4/interleukin-2)–producing (CD4) NKT subset, while CCR1, CCR6, and CXCR6 are preferentially expressed by the low cytokine-producing CD8 and CD4−CD8− subsets. In line with this, TARC/CCL17 (a CCR4 ligand) induces preferential chemotaxis of the CD4 NKT subset, while chemotactic activities of LARC/CCL20 (a CCR6 ligand) and MIP-1α/CCL3 (a CCR1 ligand) are focused on the CD8 and CD4−CD8− NKT cells. We conclude that, unlike conventional naive, memory, or effector T cells, the entire NKT cell population expresses nonlymphoid tissue homing chemokine receptors, yet NKT cell subsets differ considerably from each other by displaying distinct and reciprocal expression patterns of some chemokine receptors. Our results identify chemokine receptors that are potentially important for trafficking of human blood NKT cell subsets and reveal their function (cytokine production capacity)–dependent differential trafficking potentials.
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Cites
Chemokines — Chemotactic Cytokines That Mediate Inflammation
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Cited by
Bachelerie, F., Ben-Baruch, A., Burkhardt, A. M., Combadiere, C., Farber, J. M., Graham, G. J., Horuk, R., Sparre-Ulrich, A. H., Locati, M., Luster, A. D., et al. (2014) · Pharmacological Reviews · doi:10.1124/pr.113.007724 · Cited by 850
Invariant natural killer T cells: an innate activation scheme linked to diverse effector functions
Brennan, P. J., Brigl, M., & Brenner, M. B. (2013) · Nature Reviews Immunology · doi:10.1038/nri3369 · Cited by 835
CD4+ Invariant T-Cell–Receptor+ Natural Killer T Cells in Bronchial Asthma
Akbari, O., Faul, J. L., Hoyte, E. G., Berry, G. J., Wahlström, J., Kronenberg, M., DeKruyff, R. H., & Umetsu, D. T. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa053614 · Cited by 422
Harnessing invariant NKT cells in vaccination strategies
Cerundolo, V., Silk, J. D., Masri, S. H., & Salio, M. (2009) · Nature Reviews Immunology · doi:10.1038/nri2451 · Cited by 358
Vα24-invariant NKT cells mediate antitumor activity via killing of tumor-associated macrophages
Song, L., Asgharzadeh, S., Salo, J., Engell, K., Wu, H.-W., Sposto, R., Ara, T., Silverman, A. M., DeClerck, Y. A., Seeger, R. C., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci37869 · Cited by 342
Metadata
- Authors
- Kim, C. H., Johnston, B., & Butcher, E. C.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2002-07-01
- Volume
- 100
- Issue
- 1
- Pages
- 11-16
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W1965058145
- Cited by
- 302
- References
- 45
- FWCI
- 7.68
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kim, C. H., Johnston, B., & Butcher, E. C. (2002). Trafficking machinery of NKT cells: shared and differential chemokine receptor expression among Vα24+Vβ11+ NKT cell subsets with distinct cytokine-producing capacity. Blood. https://doi.org/10.1182/blood-2001-12-0196
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