Immunocytochemistry reveals RANKL expression of myeloma cells
Open accessAbstract
Two highly interesting papers related to osteoclastic activation in multiple myeloma were published in the December 15 issue of Blood. [1][1],[2][2] These studies were related to the imbalance of 2 molecules involved in the regulation of bone resorption: receptor activator of NF-kappaB ligand (RANKL
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Human bone marrow myeloma cells express RANKL.
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“Although normal plasma cells do not usually express RANKL, MM cells can gain the expression of this ligand [135] and interaction with RANK-expressing osteoclasts mediates their differentiation and activation through activation of NF-κB [136].”
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“Some authors believe that MM PCs express RANKL (Sezer et al, 2002; Farrugia et al, 2003; Heider et al, 2003).”
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“Although this finding differs from several studies showing RANKL expression by human primary myeloma cells [29, 30 ] and murine myeloma cell lines [31], it is consistent with others showing no RANKL expression in primary myeloma cells or myeloma cell lines [18, 19, 32], as well as with the finding that myeloma cell-me…”
BackgroundResultMultiple myeloma-A painful disease of the bone marrow.
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“In most cases, osteoclast-stimulating factors including receptor activator of NF-kB ligand (RANKL),((5,6)) macrophage inflammatory protein 1,((7,8)) and various interleukins (IL-1b,((9)) IL-3,((10)) and IL-6((11))) are produced by myeloma cells or tumor-activated cells in the bone marrow microenvironment (BMME), causi…”
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“of molecules including MIP-1alpha RANKL, MMP-13 and Decoy receptor 3 (DcR3) [41-43].”
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“Consistent with previous studies, calcium oscillations can affect RANKL secretion in MM cells by regulating NFAT signaling [23, 24].”
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Immunomodulation of Multiple Myeloma Bone Disease
Grano, M., Brunetti, G., & Colucci, S. C. (2009) · Clinical Reviews in Bone and Mineral Metabolism · doi:10.1007/s12018-009-9058-2 · Cited by 4 · see citing works
“The linkage between cells of immune system and bone loss is becoming more evident in MM and other bone loss-associated diseases through different mechanisms mainly due to the alteration of RANKL/ OPG axis [12, 42–52].”
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Autologous Hematopoietic Cell Transplantation for Multiple Myeloma
Catley, L. P., & Anderson, K. C. (2003) · doi:10.1002/9780470987070.ch92 · Cited by 3 · see citing works
Immunoregulation of Osteoclast Differentiation in Multiple Myeloma Bone Disease
Grano, M., Brunetti, G., & Colucci, S. C. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-374895-9.00006-2 · Cited by 2 · see citing works
Contribution of osteoclasts to the bone–tumor niche
Edwards, J. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-416721-6.00005-4 · Cited by 2 · see citing works
Heider, U., Zavrski, I., Jakob, C., Fleissner, C., & Sezer, O. (2004) · PubMed · Cited by 2 · see citing works
Self-citationRole of The Osteoclast in Cancer
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Osteoclasts: Potential Target for Blocking Microenvironmental Support of Myeloma
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RANKL: Targeting bone and cancer to treat skeletal complications of malignancy
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OPG, RANK and RANKL in Bone Metastasis and Cancer-Associated Osteolysis
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Huston, A. J., & Roodman, G. D. (2007) · Translational medicine series · doi:10.3109/9781420045116.003 · Cited by 1 · see citing works
Osteolyse beim Multiplen Myelom : Untersuchungen am Zellmodell
Bergmann, M., & Lorenzen, J. (2005) · RWTH Publications (RWTH Aachen)
Bedeutung von RANK-Ligand und Osteoprotegerin für den Knochenstoffwechsel
Hofbauer, L. C., & Schoppet, M. (2006) · Springer eBooks · doi:10.1007/3-540-28782-5_21
Pathophysiology of Bone Disease in Multiple Myeloma
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Defining Key Molecules in a Myeloma Cell Niche
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- Authors
- Sezer, O., Heider, U., Jakob, C., Zavrski, I., Eucker, J., Possinger, K., Sers, C., & Krenn, V.
- Affiliations
- Charité – Universitätsmedizin Berlin (DE)
- Corresponding author
- Sezer, Orhan
- Heider, Ulrike
- Jakob, Christian
- Zavrski, Ivana
- Eucker, Jan
- Possinger, Kurt
- Sers, Christine
- Krenn, Veit
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2002-06-15
- Volume
- 99
- Issue
- 12
- Pages
- 4646-4647
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2020103166
- Cited by
- 110
- References
- 7
- Citations by year
- 2022: 5 · 2021: 3 · 2020: 2 · 2019: 2 · 2018: 4 · 2017: 5 · 2015: 2 · 2014: 3 · 2013: 3 · 2012: 3
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Blood (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Multiple Myeloma Research and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Oncology › Bone health and treatments
- Keywords
- RANKL, multiple myeloma, myeloma cells, osteoclast activation, bone resorption, osteolytic lesions, NF-κB signaling
- MeSH terms
- Bone Marrow Cells, Carrier Proteins, Flow Cytometry, Humans, Immunohistochemistry, Membrane Glycoproteins, Multiple Myeloma, Neoplasm Proteins, Osteolysis, Plasma Cells, RANK Ligand, Receptor Activator of Nuclear Factor-kappa B
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