Cited by 110Multiple Myeloma Research and TreatmentsBone Metabolism and DiseasesBone health and treatments

Immunocytochemistry reveals RANKL expression of myeloma cells

Open access
Sezer, Orhan, Heider, Ulrike, Jakob, Christian, Zavrski, Ivana, Eucker, Jan, Possinger, Kurt, Sers, Christine, Krenn, Veit·2002·Blood

Abstract

Two highly interesting papers related to osteoclastic activation in multiple myeloma were published in the December 15 issue of Blood. [1][1],[2][2] These studies were related to the imbalance of 2 molecules involved in the regulation of bone resorption: receptor activator of NF-kappaB ligand (RANKL

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Crossref · 10.1182/blood-2002-01-0148

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Research works printed but not linked: 11

  1. [1]1. Cartron G, Dacheux L, Salles G, et al. Therapeutic activity of humanized antiCD20 monoclonal antibody and polymorphism in IgG Fc receptor Fc 𝛄 RIIIa gene. Blood. 2002;99:754-758.
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  8. [6]6. Hjorth-Sorensen B, Pallisgaard N, Gronholm M, Hokland P, Clausen N, Jorgensen P. A novel MLL-AF10 fusion mRNA variant in a patient with acute myeloid leukemia detected by a new asymmetric reverse transcription PCR method. Leukemia. 1997;11:1588-1593.
  9. [7]7. Prasad R, Gu Y, Alder H, et al. Cloning of the ALL-1 fusion partner, the AF-6 gene, involved in acute myeloid leukemias with the t(6;11) chromosome translocation. Cancer Res. 1993;53:5624-5628.
  10. [8]8. Tkachuk DC, Kohler S, Cleary ML. Involvement of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias. Cell. 1992;71:691-700.
  11. [9]9. Lochner K, Siegler G, Fuhrer M, et al. A specific deletion in the breakpoint cluster region of the ALL-1 gene is associated with acute lymphoblastic T-cell leukemias. Cancer Res. 1996;56:2171-2177. Figure 1. Homology models of the Fc fragment of hIgG1. The homology model has been developed using 1e4k.pdb in Brookhaven Protein Data Bank as a template. 2 The modeling has been done with SwissPdbViewer and the SwissProt modeling server. The raytracing of the figure has been done using the program PovRay in SGI computer at HumanGenomeCenter, Institute of Medical Science, the University of Tokyo. The models are superimposed onto 1e4k.pdb based on homology. Models are shown in 𝛃 -strand, 𝛂 -helical presentation connected with 𝛂 -carbon trace. The side chains of Val158 and Phe158 are shown in space filling model. (A) Docking between FCGR3A-Val and hIgG1. (B) Docking between FCGR3A-Phe and hIgG1. (C) Details of amino acid residues close to 158F of FCGR3A-Phe molecules. The side chains of IgG1 molecule within 10Å from 158 Phe are shown in balls and sticks model. <!-- image -->

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Authors
Sezer, O., Heider, U., Jakob, C., Zavrski, I., Eucker, J., Possinger, K., Sers, C., & Krenn, V.
Affiliations
Charité – Universitätsmedizin Berlin (DE)
Corresponding author
  • Sezer, Orhan
  • Heider, Ulrike
  • Jakob, Christian
  • Zavrski, Ivana
  • Eucker, Jan
  • Possinger, Kurt
  • Sers, Christine
  • Krenn, Veit
Venue
Blood
Published
2002-06-15
Volume
99
Issue
12
Pages
4646-4647
ISSN
  • 0006-4971 (ISSN-L)
  • 1528-0020
OpenAlex
W2020103166
Cited by
110
References
7
Citations by year
2022: 5 · 2021: 3 · 2020: 2 · 2019: 2 · 2018: 4 · 2017: 5 · 2015: 2 · 2014: 3 · 2013: 3 · 2012: 3
Type
journal article
Language
en
Open access
Locations
  • Blood (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Hematology › Multiple Myeloma Research and Treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
  • Health Sciences › Medicine › Oncology › Bone health and treatments
Keywords
RANKL, multiple myeloma, myeloma cells, osteoclast activation, bone resorption, osteolytic lesions, NF-κB signaling
MeSH terms
Bone Marrow Cells, Carrier Proteins, Flow Cytometry, Humans, Immunohistochemistry, Membrane Glycoproteins, Multiple Myeloma, Neoplasm Proteins, Osteolysis, Plasma Cells, RANK Ligand, Receptor Activator of Nuclear Factor-kappa B

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