The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Thrombogenic activity of doxorubicin in myeloma patients receiving thalidomide: implications for therapy
Abstract
Ten percent of newly diagnosed myeloma patients treated with any type of chemotherapy develop deep venous thrombosis (DVT). Thalidomide has proven activity in refractory multiple myeloma (MM), and although single-agent thalidomide has minimal prothrombogenic activity, its combination with cytotoxic chemotherapy is associated with a significantly increased risk of DVT. We analyzed the incidence of DVT in 232 MM patients who received a combination of chemotherapy and thalidomide on 2 protocols that differed only by the inclusion of doxorubicin in one. DT-PACE (dexamethasone/thalidomide/cisplatin/doxorubicin/cyclophos- phanide/etoposide) was offered to patients with preceding standard dose therapy, but no prior autotransplantation, while DCEP-T (dexamethasone/cyclophosphamide/etoposide/cisplatin/thalidomide) was administered for relapse after transplantation. If there were signs or symptoms suggestive of DVT, patients received additional investigations, including Doppler ultrasonography, followed by venography if indicated. Only patients on DT-PACE but not DCEP-T experienced an increased incidence of DVT. A statistical association between the incidence of DVT and combination chemotherapy including doxorubicin (P = .02) was observed; this association was confirmed on multivariate analysis. MM patients treated with thalidomide and doxorubicin have a high risk of developing DVT.
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Kyle, R. A., & Rajkumar, S. V. (2004) · New England Journal of Medicine · doi:10.1056/nejmra041875 · Cited by 1,296
Rajkumar, S. V., Blood, E., Vesole, D., Fonseca, R., & Greipp, P. R. (2006) · Journal of Clinical Oncology · doi:10.1200/jco.2005.03.0221 · Cited by 865
Multiple Myeloma: Diagnosis and Treatment
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Franks, M. E., Macpherson, G. R., & Figg, W. D. (2004) · The Lancet · doi:10.1016/s0140-6736(04)16308-3 · Cited by 615
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Metadata
- Authors
- Zangari, M., Siegel, E., Barlogie, B., Anaissie, E., Saghafifar, F., Fassas, A., Morris, C., Fink, L., & Tricot, G.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2002-08-15
- Volume
- 100
- Issue
- 4
- Pages
- 1168-1171
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2103660186
- Cited by
- 262
- References
- 18
- FWCI
- 11.70
- Type
- journal article
- Language
- en
- Open access
- closed
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- Zangari, M., Siegel, E., Barlogie, B., Anaissie, E., Saghafifar, F., Fassas, A., Morris, C., Fink, L., & Tricot, G. (2002). Thrombogenic activity of doxorubicin in myeloma patients receiving thalidomide: implications for therapy. Blood. https://doi.org/10.1182/blood-2002-01-0335
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