The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Evidence that the number of hematopoietic stem cells per animal is conserved in mammals
Abstract
Humans and larger mammals require more blood cells per lifetime than mice because of their larger size and longer life expectancy. To investigate this evolutionary adaptation, we calculated the total number of nucleated marrow cells (NMCs) per cat, observing the distribution of 59Fe to marrow, then multiplied this value (1.9 ± 0.9 × 1010 [mean ± SD]) times the frequency of feline hematopoietic stem cells (HSCs) (6 HSCs/107 NMCs) to derive the total number of HSCs per cat (11 400 ± 5400). Surprisingly, when the total number of HSCs per mouse was calculated with a similar experimental and computational approach, the value was equivalent. These data imply that the output of differentiated cells per feline HSC must vastly exceed that of murine HSCs. Furthermore, if the total number of human HSCs were also equivalent to the total number of HSCs in cat and mouse, the frequency of human HSCs would be 0.7 to 1.5 HSCs/108 NMCs, a frequency that is 20-fold less than estimated by the NOD/SCID repopulating assay.
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Cites
The serial cultivation of human diploid cell strains
Hayflick, L., & Moorhead, P. S. (1961) · Experimental Cell Research · doi:10.1016/0014-4827(61)90192-6 · Cited by 8,508
Rufer, N., Brümmendorf, T. H., Kolvraa, S., Bischoff, C., Christensen, K., Wadsworth, L., Schulzer, M., & Lansdorp, P. M. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.2.157 · Cited by 709
Cited by
Building Muscle: Molecular Regulation of Myogenesis
Bentzinger, C. F., Wang, Y. X., & Rudnicki, M. A. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008342 · Cited by 1,195
Live-animal tracking of individual haematopoietic stem/progenitor cells in their niche
Lo Celso, C., Fleming, H. E., Wu, J. W., Zhao, C. X., Miake-Lye, S., Fujisaki, J., Côté, D., Rowe, D. W., Lin, C. P., & Scadden, D. T. (2009) · Nature · doi:10.1038/nature07434 · Cited by 924
The hematopoietic stem cell in its place
Adams, G. B., & Scadden, D. T. (2006) · Nature Immunology · doi:10.1038/ni1331 · Cited by 454
Clonal haematopoiesis: connecting ageing and inflammation in cardiovascular disease
Jaiswal, S., & Libby, P. (2020) · Nature Reviews Cardiology · doi:10.1038/s41569-019-0247-5 · Cited by 386
Age-related clonal hematopoiesis
Shlush, L. I. (2018) · Blood · doi:10.1182/blood-2017-07-746453 · Cited by 281
Metadata
- Authors
- Abkowitz, J. L., Catlin, S. N., McCallie, M. T., & Guttorp, P.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2002-10-01
- Volume
- 100
- Issue
- 7
- Pages
- 2665-2667
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2014600438
- Cited by
- 232
- References
- 2
- FWCI
- 4.77
- Type
- journal article
- Language
- en
- Open access
- closed
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