Age-related clonal hematopoiesis
Open accessAbstract
Age-related alterations in the human blood system occur in B cells, T cells, cells of the innate system, as well as hematopoietic stem and progenitor cells (HSPCs). Interestingly, age-related, reduced genetic diversity can be identified at the stem cell level and also independently in B cells and T cells. This reduced diversity is most probably related to somatic mutations or to changes in the microenvironmental niche. Either process can select for specific clones or cause repeated evolutionary bottlenecks. This review discusses the age-related clonal expansions in the human HSPC pool, which was termed in the past age-related clonal hematopoiesis (ARCH). ARCH is defined as the gradual, clonal expansion of HSPCs carrying specific, disruptive, and recurrent genetic variants, in individuals without clear diagnosis of hematological malignancies. ARCH is associated not just with chronological aging but also with several other, age-related pathological conditions, including inflammation, vascular diseases, cancer mortality, and high risk for hematological malignancies. Although it remains unclear whether ARCH is a marker of aging or plays an active role in these various pathophysiologies, it is suggested here that treating or even preventing ARCH may prove to be beneficial for human health. This review also describes a decision tree for the diagnosis and follow-up for ARCH in a research setting.
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In contrast to microglia, monocyte-derived macrophages are exposed to effects of somatic mutations associated with age-related clonal hematopoiesis due to their derivation from HSC.
“In contrast to microglia, MoM F are due to their derivation from HSC exposed to effects of somatic mutations that are associated with age-related clonal hematopoiesis (CH) 29,30 .”
From Clonal hematopoiesis-associated motoric deficits caused by monocyte-derived microglia accumulating in aging mice (2025) · cites this paper as [30]
The Etiology and pathogenesis section says ARCH-related mutations may affect monocytes differently from hematopoietic stem and progenitor cells (HSPCs), and Figure 1 describes mutated HSPCs giving rise to mature cells. Our copy does not address monocyte-derived macrophages specifically or contrast them with microglia, so it supports the proposed basis only in part. Page numbers were not available in the indexed passages. (LLM, conf=0.82)
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Cites
Arber, D. A., Orazi, A., Hasserjian, R., Thiele, J., Borowitz, M. J., Le Beau, M. M., Bloomfield, C. D., Cazzola, M., & Vardiman, J. W. (2016) · Blood · doi:10.1182/blood-2016-03-643544 · Cited by 10,119 · see citing works
Age-related clonal hematopoiesis associated with adverse outcomes
Jaiswal, S., Fontanillas, P., Flannick, J., Manning, A., Grauman, P. V., Mar, B. G., Lindsley, R. C., Mermel, C. H., Burtt, N., Chavez, A., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1408617 · Cited by 4,841 · see citing works
Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence
Genovese, G., Kähler, A. K., Handsaker, R. E., Lindberg, J., Rose, S. A., Bakhoum, S. F., Chambert, K., Mick, E., Neale, B. M., Fromer, M., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1409405 · Cited by 3,531 · see citing works
Clonal hematopoiesis and risk of atherosclerotic cardiovascular disease
Jaiswal, S., Natarajan, P., Silver, A. J., Gibson, C. J., Bick, A. G., Shvartz, E., McConkey, M., Gupta, N., Gabriel, S., Ardissino, D., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1701719 · Cited by 2,683 · see citing works
Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes
Steensma, D. P., Bejar, R., Jaiswal, S., Lindsley, R. C., Sekeres, M. A., Hasserjian, R. P., & Ebert, B. L. (2015) · Blood · doi:10.1182/blood-2015-03-631747 · Cited by 1,971 · see citing works
Age-related mutations associated with clonal hematopoietic expansion and malignancies
Xie, M., Lu, C., Wang, J., McLellan, M. D., Johnson, K. J., Wendl, M. C., McMichael, J. F., Schmidt, H. K., Yellapantula, V., Miller, C. A., et al. (2014) · Nature Medicine · doi:10.1038/nm.3733 · Cited by 1,874 · see citing works
Mutation in <i>TET2</i> in Myeloid Cancers
Delhommeau, F., Dupont, S., Valle, V. D., James, C., Trannoy, S., Massé, A., Kosmider, O., Le Couedic, J.-P., Robert, F., Alberdi, A., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0810069 · Cited by 1,776 · see citing works
The origin and evolution of mutations in acute myeloid leukemia
Welch, J. S., Ley, T. J., Link, D. C., Miller, C. A., Larson, D. E., Koboldt, D. C., Wartman, L. D., Lamprecht, T. L., Liu, F., Xia, J., et al. (2012) · Cell · doi:10.1016/j.cell.2012.06.023 · Cited by 1,575 · see citing works
Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice
Fuster, J. J., MacLauchlan, S., Zuriaga, M. A., Polackal, M. N., Ostriker, A. C., Chakraborty, R., Wu, C.-L., Sano, S., Muralidharan, S., Rius, C., et al. (2017) · Science · doi:10.1126/science.aag1381 · Cited by 1,536 · see citing works
Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia
Shlush, L. I., Zandi, S., Mitchell, A., Chen, W. C., Brandwein, J. M., Gupta, V., Kennedy, J. A., Schimmer, A. D., Schuh, A. C., Yee, K. W., et al. (2014) · Nature · doi:10.1038/nature13038 · Cited by 1,443 · see citing works
Self-citationSingle-cell sequencing-based technologies will revolutionize whole-organism science
Shapiro, E., Biezuner, T., & Linnarsson, S. (2013) · Nature Reviews Genetics · doi:10.1038/nrg3542 · Cited by 1,177 · see citing works
Dnmt3a is essential for hematopoietic stem cell differentiation
Challen, G. A., Sun, D., Jeong, M., Luo, M., Jelinek, J., Berg, J. S., Bock, C., Vasanthakumar, A., Gu, H., Xi, Y., et al. (2012) · Nature Genetics · doi:10.1038/ng.1009 · Cited by 1,122 · see citing works
Role of TP53 mutations in the origin and evolution of therapy-related acute myeloid leukaemia
Wong, T. N., Ramsingh, G., Young, A. L., Miller, C. A., Touma, W., Welch, J. S., Lamprecht, T. L., Shen, D., Hundal, J., Fulton, R. S., et al. (2015) · Nature · doi:10.1038/nature13968 · Cited by 892 · see citing works
Coombs, C. C., Zehir, A., Devlin, S. M., Kishtagari, A., Syed, A., Jonsson, P., Hyman, D. M., Solit, D. B., Robson, M. E., Baselga, J., et al. (2017) · Cell stem cell · doi:10.1016/j.stem.2017.07.010 · Cited by 866 · see citing works
Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis
Busque, L., Patel, J. P., Figueroa, M. E., Vasanthakumar, A., Provost, S., Hamilou, Z., Mollica, L., Li, J., Viale, A., Heguy, A., et al. (2012) · Nature Genetics · doi:10.1038/ng.2413 · Cited by 830 · see citing works
Clonal hematopoiesis, with and without candidate driver mutations, is common in the elderly
Zink, F., Stacey, S. N., Norddahl, G. L., Frigge, M. L., Magnusson, O. T., Jonsdottir, I., Thorgeirsson, T. E., Sigurdsson, A., Gudjonsson, S. A., Gudmundsson, J., et al. (2017) · Blood · doi:10.1182/blood-2017-02-769869 · Cited by 777 · see citing works
Prognostic Mutations in Myelodysplastic Syndrome after Stem-Cell Transplantation
Lindsley, R. C., Saber, W., Mar, B. G., Redd, R., Wang, T., Haagenson, M. D., Grauman, P. V., Hu, Z.-H., Spellman, S. R., Lee, S. J., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1611604 · Cited by 776 · see citing works
Clonal evolution of preleukemic hematopoietic stem cells precedes human acute myeloid leukemia
Jan, M., Snyder, T. M., Corces-Zimmerman, M. R., Vyas, P., Weissman, I. L., Quake, S. R., & Majeti, R. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3004315 · Cited by 721 · see citing works
Corces-Zimmerman, M. R., Hong, W.-J., Weissman, I. L., Medeiros, B. C., & Majeti, R. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1324297111 · Cited by 705 · see citing works
Clonal haematopoiesis harbouring AML-associated mutations is ubiquitous in healthy adults
Young, A. L., Challen, G. A., Birmann, B. M., & Druley, T. E. (2016) · Nature Communications · doi:10.1038/ncomms12484 · Cited by 692 · see citing works
Somatic RHOA mutation in angioimmunoblastic T cell lymphoma
Sakata‐Yanagimoto, M., Enami, T., Yoshida, K., Shiraishi, Y., Ishii, R., Miyake, Y., Muto, H., Tsuyama, N., Sato‐Otsubo, A., Okuno, Y., et al. (2014) · Nature Genetics · doi:10.1038/ng.2872 · Cited by 649 · see citing works
Somatic Mutations and Clonal Hematopoiesis in Aplastic Anemia
Yoshizato, T., Dumitriu, B., Hosokawa, K., Makishima, H., Yoshida, K., Townsley, D., Sato-Otsubo, A., Sato, Y., Liu, D., Suzuki, H., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1414799 · Cited by 646 · see citing works
Detectable clonal mosaicism from birth to old age and its relationship to cancer
Laurie, C. C., Laurie, C. A., Rice, K., Doheny, K. F., Zelnick, L. R., McHugh, C. P., Ling, H., Hetrick, K. N., Pugh, E. W., Amos, C., et al. (2012) · Nature Genetics · doi:10.1038/ng.2271 · Cited by 594 · see citing works
Detectable clonal mosaicism and its relationship to aging and cancer
Jacobs, K. B., Yeager, M., Zhou, W., Wacholder, S., Wang, Z., Rodriguez-Santiago, B., Hutchinson, A., Deng, X., Liu, C., Horner, M.-J., et al. (2012) · Nature Genetics · doi:10.1038/ng.2270 · Cited by 589 · see citing works
Single-Neuron Sequencing Analysis of L1 Retrotransposition and Somatic Mutation in the Human Brain
Evrony, G. D., Cai, X., Lee, E., Hills, L. B., Elhosary, P. C., Lehmann, H. S., Parker, J. J., Atabay, K. D., Gilmore, E. C., Poduri, A., et al. (2012) · Cell · doi:10.1016/j.cell.2012.09.035 · Cited by 548 · see citing works
Nonrandom X-inactivation patterns in normal females: lyonization ratios vary with age
Busque, L., Mio, R., Mattioli, J., Brais, E., Blais, N., Lalonde, Y., Maragh, M., & Gilliland, D. (1996) · Blood · doi:10.1182/blood.v88.1.59.59 · Cited by 543 · see citing works
Leukemia-associated somatic mutations drive distinct patterns of age-related clonal hemopoiesis
McKerrell, T., Park, N., Moreno, T., Grove, C. S., Ponstingl, H., Stephens, J., Crawley, C., Craig, J., Scott, M. A., Hodkinson, C., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.02.005 · Cited by 534 · see citing works
Clonal origin of chronic myelocytic leukemia in man.
Fialkow, P., Gartler, S. M., & Yoshida, A. (1967) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.58.4.1468 · Cited by 532 · see citing works
Gibson, C. J., Lindsley, R. C., Tchekmedyian, V., Mar, B. G., Shi, J., Jaiswal, S., Bosworth, A., Francisco, L., He, J., Bansal, A., et al. (2017) · Journal of Clinical Oncology · doi:10.1200/jco.2016.71.6712 · Cited by 480 · see citing works
Clinical significance of somatic mutation in unexplained blood cytopenia
Malcovati, L., Gallì, A., Travaglino, E., Ambaglio, I., Rizzo, E., Molteni, E., Elena, C., Ferretti, V. V., Catricalà, S., Bono, E. B., et al. (2017) · Blood · doi:10.1182/blood-2017-01-763425 · Cited by 476 · see citing works
Forsberg, L. A., Rasi, C., Malmqvist, N., Davies, H., Pasupulati, S., Pakalapati, G., Sandgren, J., de Ståhl, T. D., Zaghlool, A., Giedraitis, V., et al. (2014) · Nature Genetics · doi:10.1038/ng.2966 · Cited by 460 · see citing works
Russler-Germain, D. A., Spencer, D. H., Young, M. A., Lamprecht, T. L., Miller, C. A., Fulton, R., Meyer, M. R., Erdmann-Gilmore, P., Townsend, R. R., Wilson, R. K., et al. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.02.010 · Cited by 452 · see citing works
Tefferi, A., Pardanani, A., Lim, K., Abdel-Wahab, O., Lasho, T., Patel, J., Gangat, N., Finke, C., Schwager, S., Mullally, A., et al. (2009) · Leukemia · doi:10.1038/leu.2009.47 · Cited by 441 · see citing works
Age- and tissue-specific variation of X chromosome inactivation ratios in normal women
Sharp, A. J., Robinson, D., & Jacobs, P. A. (2000) · Human Genetics · doi:10.1007/s004390000382 · Cited by 405 · see citing works
Buscarlet, M., Provost, S., Zada, Y. F., Barhdadi, A., Bourgoin, V., Lépine, G., Mollica, L., Szuber, N., Dubé, M.-P., & Busque, L. (2017) · Blood · doi:10.1182/blood-2017-04-777029 · Cited by 383 · see citing works
Gillis, N. K., Ball, M., Zhang, Q., Ma, Z., Zhao, Y., Yoder, S. J., Balasis, M. E., Mesa, T. E., Sallman, D. A., Lancet, J. E., et al. (2017) · The Lancet Oncology · doi:10.1016/s1470-2045(16)30627-1 · Cited by 317 · see citing works
Somatic mutations reveal asymmetric cellular dynamics in the early human embryo
Ju, Y. S., Martincorena, I., Gerstung, M., Petljak, M., Alexandrov, L. B., Rahbari, R., Wedge, D. C., Davies, H. R., Ramakrishna, M., Fullam, A., et al. (2017) · Nature · doi:10.1038/nature21703 · Cited by 272 · see citing works
Acquired Initiating Mutations in Early Hematopoietic Cells of CLL Patients
Damm, F., Mylonas, E., Cosson, A., Yoshida, K., Della-Valle, V., Mouly, E., Diop, M. K., Scourzic, L., Shiraishi, Y., Chiba, K., et al. (2014) · Cancer Discovery · doi:10.1158/2159-8290.cd-14-0104 · Cited by 266 · see citing works
Age-associated aneuploidy: Loss of Y chromosome from human bone marrow cells with aging
Pierre, R. V., & Hoagland, H. C. (1972) · Cancer · doi:10.1002/1097-0142(197210)30:4 · Cited by 265 · see citing works
Acuna-Hidalgo, R., Sengul, H., Steehouwer, M., van de Vorst, M., Vermeulen, S. H., Kiemeney, L. A. L. M., Veltman, J. A., Gilissen, C., & Hoischen, A. (2017) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2017.05.013 · Cited by 264 · see citing works
Mosaic PPM1D mutations are associated with predisposition to breast and ovarian cancer
Ruark, E., Snape, K. M. G., Humburg, P., Loveday, C., Bajrami, I., Brough, R., Rodrigues, D. N., Renwick, A., Seal, S., Ramsay, E., et al. (2012) · Nature · doi:10.1038/nature11725 · Cited by 247 · see citing works
Evidence that the number of hematopoietic stem cells per animal is conserved in mammals
Abkowitz, J. L., Catlin, S. N., McCallie, M. T., & Guttorp, P. M. (2002) · Blood · doi:10.1182/blood-2002-03-0822 · Cited by 233 · see citing works
Gale, R. E., Fielding, A. K., Harrison, C. N., & Linch, D. C. (1997) · British Journal of Haematology · doi:10.1046/j.1365-2141.1997.2573078.x · Cited by 228 · see citing works
Primordial cell pool size and lineage relationships of five human cell types*
Fialkow, P. J. (1973) · Annals of Human Genetics · doi:10.1111/j.1469-1809.1973.tb01813.x · Cited by 207 · see citing works
Tissue specificity of X-chromosome inactivation patterns
Gale, R. E., Wheadon, H., Boulos, P. B., & Linch, D. C. (1994) · Blood · doi:10.1182/blood.v83.10.2899.2899 · Cited by 179 · see citing works
Loss of the Y chromosome from normal and neoplastic bone marrows
(1992) · Genes Chromosomes and Cancer · doi:10.1002/gcc.2870050112 · Cited by 167 · see citing works
Single-Cell DNA-Methylation Analysis Reveals Epigenetic Chimerism in Preimplantation Embryos
Lorthongpanich, C., Cheow, L. F., Balu, S., Quake, S. R., Knowles, B. B., Burkholder, W. F., Solter, D., & Messerschmidt, D. M. (2013) · Science · doi:10.1126/science.1240617 · Cited by 154 · see citing works
Bonnefond, A., Skrobek, B., Lobbens, S., Eury, E., Thuillier, D., Cauchi, S., Lantieri, O., Balkau, B., Riboli, E., Marre, M., et al. (2013) · Nature Genetics · doi:10.1038/ng.2700 · Cited by 139 · see citing works
Fey, M., Liechti-Gallati, S., von Rohr, A., Borisch, B., Theilkas, L., Schneider, V, Oestreicher, M., Nagel, S., Ziemiecki, A., & Tobler, A. (1994) · Blood · doi:10.1182/blood.v83.4.931.931 · Cited by 138 · see citing works
Sex ratios and the risks of haematological malignancies
Cartwright, R. A., Gurney, K., & Moorman, A. V. (2002) · British Journal of Haematology · doi:10.1046/j.1365-2141.2002.03750.x · Cited by 131 · see citing works
Mossner, M., Jann, J.-C., Wittig, J., Nolte, F., Fey, S., Nowak, V., Obländer, J., Pressler, J., Palme, I., Xanthopoulos, C., et al. (2016) · Blood · doi:10.1182/blood-2015-11-679167 · Cited by 128 · see citing works
The role of monocytes in atherosclerotic coronary artery disease
Pamukçu, B., Lip, G. Y. H., Devitt, A., Griffiths, H. R., & Shantsila, E. (2010) · Annals of Medicine · doi:10.3109/07853890.2010.497767 · Cited by 127 · see citing works
Twin study of genetic and aging effects on X chromosome inactivation
Kristiansen, M. B., Knudsen, G. P., Bathum, L., Naumova, A. K., Sørensen, T. I. A., Brix, T. H., Svendsen, A. J., Christensen, K., Kyvik, K. O., & Ørstavik, K. H. (2005) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5201398 · Cited by 112 · see citing works
Somatic Mosaic Mutations in PPM1D and TP53 in the Blood of Women With Ovarian Carcinoma
Swisher, E. M., Harrell, M. I., Norquist, B. M., Walsh, T., Brady, M. F., Lee, M. J., Hershberg, R. M., Kalli, K. R., Lankes, H. A., Konnick, E. Q., et al. (2016) · JAMA Oncology · doi:10.1001/jamaoncol.2015.6053 · Cited by 104 · see citing works
Donor-engrafted CHIP is common among stem cell transplant recipients with unexplained cytopenias
Gibson, C. J., Kennedy, J. A., Nikiforow, S., Kuo, F. C., Alyea, E. P., Ho, V. T., Ritz, J., Soiffer, R. J., Antin, J. H., & Lindsley, R. C. (2017) · Blood · doi:10.1182/blood-2017-01-764951 · Cited by 91 · see citing works
An X chromosome gene regulates hematopoietic stem cell kinetics
Abkowitz, J. L., Taboada, M. R., Shelton, G. H., Catlin, S. N., Guttorp, P. M., & Kiklevich, J. V. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.7.3862 · Cited by 90 · see citing works
Shlush, L. I., Chapal-Ilani, N., Adar, R., Pery, N., Maruvka, Y. E., Spiro, A., Shouval, R., Rowe, J. M., Tzukerman, M., Bercovich, D., et al. (2012) · Blood · doi:10.1182/blood-2011-10-388629 · Cited by 72 · see citing works
Self-citationYasuda, T., Ueno, T., Fukumura, K., Yamato, A., Ando, M., Yamaguchi, H., Soda, M., Kawazu, M., Sai, E., Yamashita, Y., et al. (2013) · Leukemia · doi:10.1038/leu.2013.278 · Cited by 61 · see citing works
Kristiansen, M. B., Knudsen, G. P. S., Maguire, P., Margolin, S., Pedersen, J., Lindblom, A., & Ørstavik, K. H. (2005) · Journal of Medical Genetics · doi:10.1136/jmg.2005.032433 · Cited by 48 · see citing works
Epigenetic dysregulation of hematopoietic stem cells and preleukemic state
Kunimoto, H., & Nakajima, H. (2017) · International Journal of Hematology · doi:10.1007/s12185-017-2257-6 · Cited by 29 · see citing works
Acquired skewing of Lyonization remains stable for a prolonged period in healthy blood donors
van Dijk, J., Heuver, L. H. H., Stevens-Linders, E., Jansen, J., Mensink, E. J. B. M., Raymakers, R. A. P., & de Witte, T. (2002) · Leukemia · doi:10.1038/sj.leu.2402379 · Cited by 29 · see citing works
Shlush, L. I., & Minden, M. D. (2015) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000111 · Cited by 25 · see citing works
Self-citationX chromosome inactivation in cervical cancer patients
Kristiansen, M. B., Helland, Å., Kristensen, G. B., Olsen, A. O., Lønning, P. E., Børresen‐Dale, A., & Ørstavik, K. H. (2003) · Cancer Genetics and Cytogenetics · doi:10.1016/s0165-4608(03)00152-3 · Cited by 17 · see citing works
Tentative evidence for 3?4 haematopoetic stem cells in man
Hitzeroth, H. W., Bender, K. J., Ropers, H., & Geerthsen, J. M. P. (1977) · Human Genetics · doi:10.1007/bf00393967 · Cited by 14 · see citing works
Skewed X inactivation and survival: a 13-year follow-up study of elderly twins and singletons
Mengel‐From, J., Thinggaard, M., Christiansen, L., Vaupel, J. W., Ørstavik, K. H., & Christensen, K. (2011) · European Journal of Human Genetics · doi:10.1038/ejhg.2011.215 · Cited by 12 · see citing works
Age-dependency of somatic selection in South African Negro G-6-PD heterozygotes
Hitzeroth, H. W., & Bender, K. J. (1981) · Human Genetics · doi:10.1007/bf00294934 · Cited by 10 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- Young AL, Challen GA, Birmann BM, Druley TE. Clonal haematopoiesis harbouring AML- associated mutations is ubiquitous in healthy adults. Nat Commun. 2016;7:12484.
- Shlush LI, Minden MD. Preleukemia: the normal side of cancer. Curr Opin Hematol. 2015;22(2):77-84.
Cited by
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Pan-cancer analysis of whole genomes
The ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium, Aaltonen, L. A., Abascal, F., Abeshouse, A., Aburatani, H., Adams, D. J., Agrawal, N., Ahn, K. S., Ahn, S.-M., Aikata, H., et al. (2020) · Nature · doi:10.1038/s41586-020-1969-6 · Cited by 3,064 · see citing works
Liquid biopsy enters the clinic — implementation issues and future challenges
Ignatiadis, M., Sledge, G. W., & Jeffrey, S. S. (2021) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-020-00457-x · Cited by 1,191 · see citing works
Prediction of acute myeloid leukaemia risk in healthy individuals
Abelson, S., Collord, G., Ng, S. W. K., Weissbrod, O., Mendelson Cohen, N., Niemeyer, E., Barda, N., Zuzarte, P. C., Heisler, L., Sundaravadanam, Y., et al. (2018) · Nature · doi:10.1038/s41586-018-0317-6 · Cited by 850 · see citing works
Self-citationLegius, E., Messiaen, L. M., Wolkenstein, P., Pancza, P., Avery, R. A., Berman, Y. D., Blakeley, J. O., Babovic‐Vuksanovic, D., Cunha, K. S., Ferner, R. E., et al. (2021) · Genetics in Medicine · doi:10.1038/s41436-021-01170-5 · Cited by 834 · see citing works
Molecular Minimal Residual Disease in Acute Myeloid Leukemia
Jongen‐Lavrencic, M., Grob, T., Hanekamp, D., Kavelaars, F. G., Hinai, A. S. A. A., Zeilemaker, A., Erpelinck-Verschueren, C. A. J., Gradowska, P. L., Meijer, R. J., Cloos, J. J., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1716863 · Cited by 783 · see citing works
Heuser, M., Freeman, S. D., Ossenkoppele, G. J., Buccisano, F., Hourigan, C. S., Ngai, L. L., Tettero, J. M., Bachas, C., Baer, C. R., Béné, M. C., et al. (2021) · Blood · doi:10.1182/blood.2021013626 · Cited by 767 · see citing works
Brain immunology and immunotherapy in brain tumours
Sampson, J. H., Gunn, M. D., Fecci, P. E., & Ashley, D. M. (2019) · Nature reviews. Cancer · doi:10.1038/s41568-019-0224-7 · Cited by 733 · see citing works
Ageing and atherosclerosis: vascular intrinsic and extrinsic factors and potential role of IL-6
Tyrrell, D. J., & Goldstein, D. R. (2020) · Nature Reviews Cardiology · doi:10.1038/s41569-020-0431-7 · Cited by 434 · see citing works
Acute myeloid leukemia: 2019 update on risk‐stratification and management
Estey, E. H. (2018) · American Journal of Hematology · doi:10.1002/ajh.25214 · Cited by 374 · see citing works
Thol, F. R., Gabdoulline, R. R., Liebich, A., Klement, P., Schiller, J., Kandziora, C., Hambach, L., Stadler, M., Koenecke, C., Flintrop, M., et al. (2018) · Blood · doi:10.1182/blood-2018-02-829911 · Cited by 298 · see citing works
Clinical consequences of clonal hematopoiesis of indeterminate potential
Steensma, D. P. (2018) · Blood Advances · doi:10.1182/bloodadvances.2018020222 · Cited by 192 · see citing works
Clinical consequences of clonal hematopoiesis of indeterminate potential
Steensma, D. P. (2018) · Hematology · doi:10.1182/asheducation-2018.1.264 · Cited by 188 · see citing works
Wang, Y., Sano, S., Yura, Y., Ke, Z., Sano, M., Oshima, K., Ogawa, H., Horitani, K., Min, K.-D., Miura-Yura, E., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.135204 · Cited by 167 · see citing works
Cardiovascular Disease, Aging, and Clonal Hematopoiesis
Evans, M. A., Sano, S., & Walsh, K. (2019) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-012419-032544 · Cited by 163 · see citing works
Somatic Mutations and Clonal Hematopoiesis
Fuster, J. J., & Walsh, K. (2018) · Circulation Research · doi:10.1161/circresaha.117.312115 · Cited by 163 · see citing works
Molecular mechanisms of the preventable causes of cancer in the United StatesPreprint
Golemis, E. A., Scheet, P. A., Beck, T. N., Scolnick, E. M., Hunter, D. J., Hawk, E. T., & Hopkins, N. H. (2018) · Genes & Development · doi:10.1101/gad.314849.118 · Cited by 156 · see citing works
Laying the foundation for genomically-based risk assessment in chronic myeloid leukemia
on behalf of the International CML Foundation Genomics Alliance, Branford, S., Kim, D. D. H., Apperley, J. F., Eide, C. A., Mustjoki, S., Ong, S. T., Nteliopoulos, G., Ernst, T., Chuah, C., et al. (2019) · Leukemia · doi:10.1038/s41375-019-0512-y · Cited by 149 · see citing works
Comorbid and inflammatory characteristics of genetic subtypes of clonal hematopoiesis
Cook, E. K., Izukawa, T., Young, S., Rosen, G., Jamali, M., Zhang, L., Johnson, D., Bain, E., Hilland, J., Ferrone, C. K., et al. (2019) · Blood Advances · doi:10.1182/bloodadvances.2018024729 · Cited by 145 · see citing works
Clonal dynamics in early human embryogenesis inferred from somatic mutation
Park, S., Mali, N. M., Kim, R., Choi, J., Lee, J., Lim, J., Park, J. M., Park, J. W., Kim, D., Kim, T., et al. (2021) · Nature · doi:10.1038/s41586-021-03786-8 · Cited by 142 · see citing works
Combined landscape of single-nucleotide variants and copy number alterations in clonal hematopoiesis
Saiki, R., Momozawa, Y., Nannya, Y., Nakagawa, M. M., Ochi, Y., Yoshizato, T., Terao, C., Kuroda, Y., Shiraishi, Y., Chiba, K., et al. (2021) · Nature Medicine · doi:10.1038/s41591-021-01411-9 · Cited by 141 · see citing works
Rolfo, C. D., Cardona, A. F., Cristofanilli, M., Paz-Ares, L. G., Díaz‐Mochon, J. J., Durán, I., Raez, L. E., Russo, A., Lorente, J. A., Malapelle, U., et al. (2020) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2020.102978 · Cited by 139 · see citing works
Granulopoiesis and Neutrophil Homeostasis: A Metabolic, Daily Balancing Act
Yvan‐Charvet, L., & Ng, L. G. (2019) · Trends in Immunology · doi:10.1016/j.it.2019.05.004 · Cited by 130 · see citing works
Coombs, C. C., Gillis, N., Tan, X. M., Berg, J. S., Ball, M., Balasis, M. E., Montgomery, N. D., Bolton, K. L., Parker, J. S., Mesa, T., et al. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-1201 · Cited by 127 · see citing works
Losing Sense of Self and Surroundings: Hematopoietic Stem Cell Aging and Leukemic Transformation
Verovskaya, E. V., Dellorusso, P. V., & Passegue, E. A. (2019) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2019.04.006 · Cited by 122 · see citing works
Clonal hematopoiesis driven by mutated DNMT3A promotes inflammatory bone loss
Wang, H., Divaris, K., Pan, B., Li, X., Lim, J., Saha, G., Barovic, M., Giannakou, D., Korostoff, J. M., Bing, Y., et al. (2024) · Cell · doi:10.1016/j.cell.2024.05.003 · Cited by 119 · see citing works
Clonal hematopoiesis, somatic mosaicism, and age-associated disease
Evans, M. A., & Walsh, K. (2022) · Physiological Reviews · doi:10.1152/physrev.00004.2022 · Cited by 105 · see citing works
Takayama, N., Murison, A., Takayanagi, S., Arlidge, C., Zhou, S., García‐Prat, L., Chan‐Seng‐Yue, M., Zandi, S., Gan, O. I., Boutzen, H., et al. (2020) · Cell stem cell · doi:10.1016/j.stem.2020.11.001 · Cited by 104 · see citing works
Fujino, T., Goyama, S., Sugiura, Y., Inoue, D., Asada, S., Yamasaki, S., Matsumoto, A., Yamaguchi, K., Isobe, Y., Tsuchiya, A., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-22053-y · Cited by 101 · see citing works
ICUS, IDUS, CHIP and CCUS: Diagnostic Criteria, Separation from MDS and Clinical Implications
Valent, P. (2018) · Pathobiology · doi:10.1159/000489042 · Cited by 99 · see citing works
New Insights from Studies of Clonal Hematopoiesis
Gibson, C. J., & Steensma, D. P. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-17-3044 · Cited by 94 · see citing works
Clinical, histopathological and molecular characterization of hypoplastic myelodysplastic syndrome
Bono, E. B., McLornan, D. P., Travaglino, E., Gandhi, S., Gallì, A., Khan, A. A., Kulasekararaj, A. G., Boveri, E., Raj, K. K., Elena, C., et al. (2019) · Leukemia · doi:10.1038/s41375-019-0457-1 · Cited by 93 · see citing works
Are trade‐offs really the key drivers of ageing and life span?
Cohen, A. A., Coste, C. F. D., Li, X., Bourg, S., & Pavard, S. (2019) · Functional Ecology · doi:10.1111/1365-2435.13444 · Cited by 92 · see citing works
When Tissue is an Issue the Liquid Biopsy is Nonissue: A Review
Rodríguez, J. K., Ávila, J., Rolfo, C. D., Ruíz-Patiño, A., Russo, A., Ricaurte, L., Ordóñez‐Reyes, C., Arrieta, O. G., Zatarain-Barrón, Z. L., Recondo, G., et al. (2021) · Oncology and Therapy · doi:10.1007/s40487-021-00144-6 · Cited by 89 · see citing works
Yura, Y., Miura-Yura, E., Katanasaka, Y., Min, K.-D., Chavkin, N., Polizio, A. H., Ogawa, H., Horitani, K., Doviak, H., Evans, M. A., et al. (2021) · Circulation Research · doi:10.1161/circresaha.121.319314 · Cited by 87 · see citing works
Evolutionary landscape of clonal hematopoiesis in 3,359 individuals from the general population
van Zeventer, I. A., de Graaf, A. O., Salzbrunn, J. B., Nolte, I. M., Kamphuis, P., Dinmohamed, A. G., van der Reijden, B. A., Schuringa, J. J., Jansen, J. H., & Huls, G. A. (2023) · Cancer Cell · doi:10.1016/j.ccell.2023.04.006 · Cited by 82 · see citing works
Clonal Hematopoiesis of Indeterminate Potential Reshapes Age-Related CVD
Khetarpal, S. A., Qamar, A., Bick, A. G., Fuster, J. J., Kathiresan, S., Jaiswal, S., & Natarajan, P. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2019.05.045 · Cited by 85 · see citing works
Clinical exome sequencing—Mistakes and caveats
Corominas, J., Smeekens, S. P., Nelen, M. R., Yntema, H. G., Kamsteeg, E., Pfundt, R., & Gilissen, C. (2022) · Human Mutation · doi:10.1002/humu.24360 · Cited by 76 · see citing works
EASIX for prediction of survival in lower-risk myelodysplastic syndromes
Merz, A. M. A., Germing, U., Kobbe, G., Kaivers, J., Jauch, A. S., Radujkovic, A., Hummel, M., Benner, A., Merz, M., Dreger, P., et al. (2019) · Blood Cancer Journal · doi:10.1038/s41408-019-0247-z · Cited by 76 · see citing works
Liquid biopsy tracking of lung tumor evolutions over time
Russo, A., de Miguel‐Pérez, D., Gunasekaran, M., Scilla, K. A., Lapidus, R. S., Cooper, B., Mehra, R., Adamo, V., Malapelle, U., & Rolfo, C. D. (2019) · Expert Review of Molecular Diagnostics · doi:10.1080/14737159.2020.1680287 · Cited by 74 · see citing works
Connections Between Clonal Hematopoiesis, Cardiovascular Disease, and Cancer
Arguelles, O. C., Jaiswal, S., Shlush, L. I., Moslehi, J. J., Schimmer, A. D., Barac, A., & Thavendiranathan, P. (2019) · JAMA Cardiology · doi:10.1001/jamacardio.2019.0302 · Cited by 72 · see citing works
Self-citationClinical Relevance of Clonal Hematopoiesis in the Oldest-Old Population
Rossi, M., Meggendorfer, M., Zampini, M., Tettamanti, M., Riva, E., Travaglino, E., Bersanelli, M., Mandelli, S., Galbussera, A. A., Mosca, E., et al. (2020) · Blood · doi:10.1182/blood.2021011320 · Cited by 71 · see citing works
Inflammatory signals from fatty bone marrow support DNMT3A driven clonal hematopoiesis
Zioni, N., Bercovich, A. A., Chapal-Ilani, N., Bacharach, T., Rappoport, N., Solomon, A., Avraham, R., Kopitman, E., Porat, Z., Sacma, M., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-36906-1 · Cited by 67 · see citing works
Self-citationClonal Hematopoiesis: A New Step Linking Inflammation to Heart Failure
Yura, Y., Sano, S., & Walsh, K. X. (2020) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2019.08.006 · Cited by 67 · see citing works
Clonal hematopoiesis as a model for premalignant changes during aging
Steensma, D. P., & Ebert, B. L. (2019) · Experimental Hematology · doi:10.1016/j.exphem.2019.12.001 · Cited by 65 · see citing works
Gondek, L. P., & Dezern, A. E. (2019) · The Lancet Haematology · doi:10.1016/s2352-3026(19)30211-x · Cited by 63 · see citing works
High prevalence of clonal hematopoiesis in the blood and bone marrow of healthy volunteers
Guermouche, H., Ravalet, N., Gallay, N., Deswarte, C., Foucault, A., Beaud, J., Rault, E., Saindoy, E., Lachot, S., Martignoles, J., et al. (2020) · Blood Advances · doi:10.1182/bloodadvances.2020001582 · Cited by 64 · see citing works
Gaga, M., Chorostowska‐Wynimko, J., Horváth, I., Tammemägi, M. C., Shitrit, D., Eisenberg, V. H., Liang, H., Stav, D., Faber, D. L., Jansen, M. A. M., et al. (2020) · European Respiratory Journal · doi:10.1183/13993003.02682-2020 · Cited by 61 · see citing works
Clonal Hematopoiesis: From Mechanisms to Clinical Intervention
Köhnke, T., & Majeti, R. (2021) · Cancer Discovery · doi:10.1158/2159-8290.cd-21-0901 · Cited by 59 · see citing works
Cardiovascular Disease Among Patients With AML and CHIP-Related Mutations
Arguelles, O. C., Schöffel, A. C., Capo‐Chichi, J., Abdel-Qadir, H. M., Schuh, A. C., Estrada, M. C., Liu, S., Gupta, V. K., Schimmer, A. D., Yee, K. W. L., et al. (2022) · JACC CardioOncology · doi:10.1016/j.jaccao.2021.11.008 · Cited by 59 · see citing works
Self-citationCalcium regulation of stem cells
Snoeck, H. (2020) · EMBO Reports · doi:10.15252/embr.202050028 · Cited by 55 · see citing works
Kemps, P. G., Hebeda, K. M., Pals, S. T., Verdijk, R. M., Lam, K. H., Bruggink, A. H., de Lil, H. S., Ruiterkamp, B., de Heer, K., van Laar, J. A. M., et al. (2020) · The Journal of Pathology Clinical Research · doi:10.1002/cjp2.177 · Cited by 57 · see citing works
The Source and Dynamics of Adult Hematopoiesis: Insights from Lineage Tracing
Pucella, J. N., Upadhaya, S., & Reizis, B. (2020) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-020520-114601 · Cited by 53 · see citing works
Clonal hematopoiesis in elderly twins: concordance, discordance, and mortality
Hansen, J. W., Pedersen, D. A., Larsen, L. A., Husby, S., Clemmensen, S. B., Hjelmborg, J., Favero, F., Weischenfeldt, J., Christensen, K., & Grønbæk, K. (2019) · Blood · doi:10.1182/blood.2019001793 · Cited by 53 · see citing works
Next‐generation sequencing for measurable residual disease detection in acute myeloid leukaemia
Ghannam, J. Y., Dillon, L. W., & Hourigan, C. S. (2019) · British Journal of Haematology · doi:10.1111/bjh.16362 · Cited by 53 · see citing works
Gambin, T., Liu, Q., Karolak, J. A., Grochowski, C. M., Xie, N. G., Wu, L. R., Yan, Y. H., Cao, Y., Coban‐Akdemir, Z., Wilson, T. A., et al. (2020) · Genetics in Medicine · doi:10.1038/s41436-020-0897-z · Cited by 51 · see citing works
Febbraio, M., Roy, C. B., & Levin, L. (2021) · International Dental Journal · doi:10.1016/j.identj.2021.07.006 · Cited by 51 · see citing works
David, C., Duployez, N., Eloy, P., Belhadi, D., Chezel, J., Guern, V. L., Laouenan, C., Fenwarth, L., Rouzaud, D., Mathian, A., et al. (2022) · Rheumatology · doi:10.1093/rheumatology/keac108 · Cited by 52 · see citing works
Atrial Fibrillation and Clonal Hematopoiesis in TET2 and ASXL1
Saadatagah, S., Naderian, M., Uddin, M. M., Dikilitas, O., Niroula, A., Schuermans, A., Selvin, E., Hoogeveen, R. C., Matsushita, K., Nambi, V., et al. (2024) · JAMA Cardiology · doi:10.1001/jamacardio.2024.0459 · Cited by 51 · see citing works
Gurnari, C., Pascale, M. R., Vitale, A., Diral, E., Tomelleri, A., Galossi, E., Falconi, G., Bruno, A., Crisafulli, F., Frassi, M., et al. (2023) · American Journal of Hematology · doi:10.1002/ajh.27169 · Cited by 47 · see citing works
Clonal Hematopoiesis Risk Score and All-Cause and Cardiovascular Mortality in Older Adults
Saadatagah, S., Uddin, M. M., Weeks, L. D., Niroula, A., Ru, M., Takahashi, K., Gondek, L. P., Yu, B., Bick, A. G., Ebert, B. L., et al. (2024) · JAMA Network Open · doi:10.1001/jamanetworkopen.2023.51927 · Cited by 45 · see citing works
Clonal hematopoiesis: Pre-cancer PLUS
Silver, A. J., & Jaiswal, S. (2019) · Advances in cancer research · doi:10.1016/bs.acr.2018.12.003 · Cited by 44 · see citing works
Mutations in normal tissues—some diagnostic and clinical implications
Fiala, C., & Diamandis, E. P. (2020) · BMC Medicine · doi:10.1186/s12916-020-01763-y · Cited by 42 · see citing works
Macrophages at the Crossroad of Meta-Inflammation and Inflammaging
Qu, L., Matz, A., Karlinsey, K. S., Cao, Z., Vella, A. T., & Zhou, B. (2022) · Genes · doi:10.3390/genes13112074 · Cited by 40 · see citing works
Bone marrow inflammatory memory in cardiometabolic disease and inflammatory comorbidities
Mitroulis, I., Hajishengallis, G., & Chavakis, T. (2023) · Cardiovascular Research · doi:10.1093/cvr/cvad003 · Cited by 39 · see citing works
Castelli, G., Pelosi, E., & Testa, U. (2019) · Cancers · doi:10.3390/cancers11020260 · Cited by 38 · see citing works
Calibration-free NGS quantitation of mutations below 0.01% VAF
Dai, P., Wu, L. R., Chen, S. X., Wang, M., Cheng, L. Y., Zhang, J. X., Hao, P., Yao, W., Zarka, J. G., Issa, G. C., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-26308-6 · Cited by 37 · see citing works
Loss of ATF4 leads to functional aging-like attrition of adult hematopoietic stem cells
Sun, Y., Lin, X., Liu, B., Zhang, Y.-X., Li, W., Zhang, S., He, F., Tian, H., Zhu, X., Liu, X.-M., et al. (2021) · Science Advances · doi:10.1126/sciadv.abj6877 · Cited by 34 · see citing works
Steensma, D. P. (2019) · Current Hematologic Malignancy Reports · doi:10.1007/s11899-019-00547-3 · Cited by 35 · see citing works
Onecha, E., Rapado, I., Morales, M. L., Carreño‐Tarragona, G., Martínez‐Sánchez, P., Gutiérrez, X., Pina, J. M. S., Linares, M., Gallardo, M., Martínez‐López, J., et al. (2020) · Haematologica · doi:10.3324/haematol.2020.254623 · Cited by 36 · see citing works
Updates on Old and Weary Haematopoiesis
Konieczny, J., & Arranz, L. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19092567 · Cited by 33 · see citing works
Recurrent deletions in clonal hematopoiesis are driven by microhomology-mediated end joining
Feldman, T., Bercovich, A., Moskovitz, Y., Chapal-Ilani, N., Mitchell, A., Medeiros, J. J. F., Biezuner, T., Kaushansky, N., Minden, M. D., Gupta, V. K., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-22803-y · Cited by 33 · see citing works
Self-citationMitchell, K., & Steidl, U. G. (2019) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a036251 · Cited by 34 · see citing works
Kim, J.-S., Trzebanski, S., Shin, S.-H., Schori, L., Frumer Friedman, G. R., Ilani, N. C., Kadam, A., Vicario, R., Aust, O., Bugaeva, P., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115609 · Cited by 33 · see citing works
Self-citationAyachi, S., Buscarlet, M., & Busque, L. (2020) · Experimental Hematology · doi:10.1016/j.exphem.2020.01.008 · Cited by 32 · see citing works
Role of TET dioxygenases in the regulation of both normal and pathological hematopoiesis
Joshi, K., Zhang, L., Breslin, P., Kini, A. R., & Zhang, J. (2022) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-022-02496-x · Cited by 30 · see citing works
Clonal hematopoiesis of indeterminate potential and the risk of autoimmune diseases
Wu, H., Wei, J., Yu, Y., Wang, N., & Tan, X. W. (2025) · Journal of Internal Medicine · doi:10.1111/joim.20080 · Cited by 32 · see citing works
Fate of Hematopoiesis During Aging. What Do We Really Know, and What are its Implications?
Broxmeyer, H. E., Liu, Y., Kapur, R., Orschell, C. M., Aljoufi, A., Ropa, J. P., Trinh, T. L. P., Burns, S. S., & Capitano, M. L. (2020) · Stem Cell Reviews and Reports · doi:10.1007/s12015-020-10065-y · Cited by 30 · see citing works
Hofman, P. M. (2021) · Cancers · doi:10.3390/cancers13092049 · Cited by 30 · see citing works
Translating Evidence from Clonal Hematopoiesis to Cardiovascular Disease: A Systematic Review
Papa, V., Marracino, L., Fortini, F., Rizzo, P., Campo, G. C., Vaccarezza, M., & Sega, F. V. D. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9082480 · Cited by 29 · see citing works
Grenier‐Pleau, I., Tyryshkin, K., Le, T. D., Rudan, J. F., Bonneil, É., Thibault, P., Zeng, K., Lässer, C., Mallinson, D., Lamprou, D. A., et al. (2020) · Aging Cell · doi:10.1111/acel.13245 · Cited by 29 · see citing works
Domogala, D., Gambin, T., Zemet, R., Wu, C. W., Schulze, K., Yang, Y., Wilson, T. A., Machol, I., Liu, P., & Stankiewicz, P. (2021) · Human Genomics · doi:10.1186/s40246-021-00369-6 · Cited by 28 · see citing works
Regulation of stress-induced hematopoiesis
Anderson, G. A., Rodriguez, M., & Kathrein, K. L. (2020) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000589 · Cited by 27 · see citing works
Cook, C. B., Armstrong, L., Boerkoel, C. F., Clarke, L. A., du Souich, C., Demos, M. K., Gibson, W. T., Gill, H., Lopez‐Rangel, E., Patel, M. S., et al. (2021) · Molecular Case Studies · doi:10.1101/mcs.a006125 · Cited by 27 · see citing works
Pathophysiology of chronic lymphocytic leukemia and human B1 cell development
Kikushige, Y. (2019) · International Journal of Hematology · doi:10.1007/s12185-019-02788-7 · Cited by 25 · see citing works
Isocitrate Dehydrogenase Mutations in Myelodysplastic Syndromes and in Acute Myeloid Leukemias
Testa, U., Castelli, G., & Pelosi, E. (2020) · Cancers · doi:10.3390/cancers12092427 · Cited by 26 · see citing works
Truty, R., Rojahn, S., Ouyang, K., Kautzer, C., Kennemer, M. I., Pineda‐Alvarez, D., Johnson, B. A., Stafford, A., Basel‐Vanagaite, L., Saitta, S. C., et al. (2023) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2023.02.013 · Cited by 25 · see citing works
Rhee, J., Bolton, K. L., Gupta, D., Weeks, L. D., Bick, A. G., Tall, A. R., Walsh, K., Fuster, J. J., & Natarajan, P. (2026) · Circulation · doi:10.1161/cir.0000000000001404 · Cited by 27 · see citing works
Epigenetic Changes as a Target in Aging Haematopoietic Stem Cells and Age-Related Malignancies
Buisman, S. C., & de Haan, G. (2019) · Cells · doi:10.3390/cells8080868 · Cited by 24 · see citing works
Somatic Mutations and Clonal Hematopoiesis as Drivers of Age-Related Cardiovascular Risk
Haring, B., Wissel, S., & Manson, J. E. (2022) · Current Cardiology Reports · doi:10.1007/s11886-022-01724-2 · Cited by 26 · see citing works
Machiela, M. J. (2019) · Current Opinion in Oncology · doi:10.1097/cco.0000000000000500 · Cited by 24 · see citing works
Evolutionary trajectory of leukemic clones and its clinical implications
Tuval, A., & Shlush, L. I. (2019) · Haematologica · doi:10.3324/haematol.2018.195289 · Cited by 26 · see citing works
Self-citationHiraiwa, H., Yura, Y., Okumura, T., & Murohara, T. (2024) · Heart Failure Reviews · doi:10.1007/s10741-024-10418-6 · Cited by 23 · see citing works
Patkar, N. V., Shaikh, A. F., Kakirde, C., Nathany, S., Ramesh, H., Bhanshe, P., Joshi, S., Chaudhary, S., Kannan, S., Hasan, S. K., et al. (2019) · Blood Cancer Journal · doi:10.1038/s41408-019-0244-2 · Cited by 22 · see citing works
Relationship between Aging and Hematopoietic Cell Transplantation
Cupit-Link, M. C., Arora, M., Wood, W. A., & Hashmi, S. K. (2018) · Transplantation and Cellular Therapy · doi:10.1016/j.bbmt.2018.08.015 · Cited by 21 · see citing works
Rožman, P. J. (2018) · GeroScience · doi:10.1007/s11357-018-0027-x · Cited by 20 · see citing works
Combined landscape of single-nucleotide variants and copy-number alterations in clonal hematopoiesisPreprint
Saiki, R., Momozawa, Y., Nannya, Y., Nakagawa, M. M., Ochi, Y., Yoshizato, T., Terao, C., Kuroda, Y., Shiraishi, Y., Chiba, K., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.03.05.433727 · Cited by 22 · see citing works
Moritz, J. M., Schwab, A., Reinisch, A., Zebisch, A., Sill, H., & Wölfler, A. (2024) · Biomedicines · doi:10.3390/biomedicines12030599 · Cited by 20 · see citing works
Stem Cell Aging and Regenerative Medicine
De, D., Karmakar, P., & Bhattacharya, D. (2020) · Advances in experimental medicine and biology · doi:10.1007/5584_2020_577 · Cited by 20 · see citing works
Acute myeloid leukaemia in patients we judge as being older and/or unfit
Lazarević, V. (2021) · Journal of Internal Medicine · doi:10.1111/joim.13293 · Cited by 20 · see citing works
Extracellular Vesicles and Hematopoietic Stem Cell Aging
Goldberg, L. R. (2021) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.120.314643 · Cited by 20 · see citing works
- Authors
- Shlush, L. I.
- Affiliations
- Rambam Health Care Campus (IL)
- Corresponding author
- Shlush, Liran I.
- ORCID
- Shlush, Liran I.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2018-02-01
- Volume
- 131
- Issue
- 5
- Pages
- 496-504
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2770273110
- Cited by
- 281
- References
- 66
- Citations by year
- 2026: 17 · 2025: 27 · 2024: 20 · 2023: 27 · 2022: 31 · 2021: 48 · 2020: 46 · 2019: 43 · 2018: 22
- FWCI
- 4.79
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Blood (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Blood disorders and treatments
- Keywords
- age-related clonal hematopoiesis, hematopoietic stem and progenitor cells, clonal expansion, somatic mutations, clonal evolution, hematological malignancy risk, inflammation, vascular disease, aging, B cells, T cells, hematopoietic niche
- MeSH terms
- Aging, Animals, Clone Cells, Hematopoiesis, Hematopoietic Stem Cells, Humans, Genetic Variation, Hematologic Neoplasms, Clonal Evolution
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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