The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Hematopoietic stem cell and progenitor defects in Sca-1/Ly-6A–null mice
Open accessAbstract
Despite its wide use as a marker for hematopoietic stem cells (HSCs), the function of stem cell antigen–1 (Sca-1) (also known as lymphocyte activation protein–6A [Ly-6A]) in hematopoiesis remains poorly defined. We have previously established that Sca-1−/−T cells develop normally, although they are hyperresponsive to antigen. Here, we report detailed analysis of hematopoiesis in Sca-1–deficient animals. The differentiation potential of Sca-1–null bone marrow was determined from examination of the most mature precursors (culture colony-forming units [CFU-Cs]) to less committed progenitors (spleen CFUs [CFU-Ss]) to long-term repopulating HSCs. Sca-1–null mice are mildly thrombocytopenic with a concomitant decrease in megakaryocytes and their precursors. Bone marrow cells derived fromSca-1−/− mice also have decreased multipotential granulocyte, erythroid, macrophage, and megakaryocyte CFU (GEMM-CFU) and CFU-S progenitor activity. Competitive repopulation assays demonstrated that Sca-1−/−HSCs are at a competitive disadvantage compared with wild-type HSCs. To further analyze the potential of Sca-1−/−HSCs, serial transplantations were performed. While secondary repopulations using wild-type bone marrow completely repopulatedSca-1−/−mice, Sca-1−/−bone marrow failed to rescue one third of lethally irradiated wild-type mice receiving secondary bone marrow transplants from irradiation-induced anemia and contributed poorly to the surviving transplant recipients. These data strongly suggest that Sca-1 is required for regulating HSC self-renewal and the development of committed progenitor cells, megakaryocytes, and platelets. Thus, our studies conclusively demonstrate that Sca-1, in addition to being a marker of HSCs, regulates the developmental program of HSCs and specific progenitor populations.
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Cites
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Akashi, K., Traver, D., Miyamoto, T., & Weissman, I. L. (2000) · Nature · doi:10.1038/35004599 · Cited by 2,617
Identification of Clonogenic Common Lymphoid Progenitors in Mouse Bone Marrow
Kondo, M., Weissman, I. L., & Akashi, K. (1997) · Cell · doi:10.1016/s0092-8674(00)80453-5 · Cited by 2,253
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“A more recent follow-up study [118] related the increased fibrosis of Sca-1-deficient mice to a reduced recruitment of IgM and C3 to injured muscle, due to a specific reduction in peritoneal IgM-producing B-1a cells.”
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Flenniken, A. M., Osborne, L. R., Anderson, N., Ciliberti, N., Fleming, C., Gittens, J. E. I., Gong, X.-Q., Kelsey, L. B., Lounsbury, C., Moreno, L., et al. (2005) · Development · doi:10.1242/dev.02011 · Cited by 231
Self-citationThe GPI-Linked Protein LY6A Drives AAV-PHP.B Transport across the Blood-Brain Barrier
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Metadata
- Authors
- Ito, C. Y., Li, C. Y. J., Bernstein, A., Dick, J. E., & Stanford, W. L.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2003-01-15
- Volume
- 101
- Issue
- 2
- Pages
- 517-523
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W1966177375
- Cited by
- 187
- References
- 2
- FWCI
- 6.21
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Ito, C. Y., Li, C. Y. J., Bernstein, A., Dick, J. E., & Stanford, W. L. (2003). Hematopoietic stem cell and progenitor defects in Sca-1/Ly-6A–null mice. Blood. https://doi.org/10.1182/blood-2002-06-1918
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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