The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
IL-15 is an essential mediator of peripheral NK-cell homeostasis
Open accessAbstract
Several distinct classes of surface receptors can, on ligand binding, transmit signals that modulate the survival, proliferation, and apoptosis of peripheral B, T, and natural killer (NK) cells. At the population level, dynamic changes in lymphocyte cell numbers are strictly regulated to maintain a steady state, a process referred to as homeostasis. Although several studies have investigated the signals that regulate B- and T-cell homeostasis, little is known about the mechanisms that control the survival and proliferation of peripheral NK cells. Using an adoptive transfer system, we have investigated the role of γc-dependent cytokines, in particular interleukin 7 (IL-7) and IL-15, and major histocompatibility complex (MHC) class I molecules in peripheral NK-cell homeostasis. We observed that IL-15 plays a dominant role in the survival of peripheral NK cells, via maintenance of the antiapoptotic factor Bcl-2. IL-15 availability, however, also plays an important role because endogenous NK cells in the recipient mice influence the behavior of adoptively transferred NK cells. Finally, although NK cells bear functional inhibitory Ly49 receptors for MHC class I molecules, the presence or absence of specific ligands on host cells did not influence the survival or homeostatic expansion of donor NK cells.
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Cites
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IL-15 Receptor Maintains Lymphoid Homeostasis by Supporting Lymphocyte Homing and Proliferation
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Self-citation
Cited by
Maturation of mouse NK cells is a 4-stage developmental program
Chiossone, L., Chaix, J., Fuseri, N., Roth, C., Vivier, E., & Walzer, T. (2009) · Blood · doi:10.1182/blood-2008-10-187179 · Cited by 787
T-bet Regulates the Terminal Maturation and Homeostasis of NK and Vα14i NKT Cells
Townsend, M. J., Weinmann, A. S., Matsuda, J. L., Salomon, R., Farnham, P. J., Biron, C. A., Gapin, L., & Glimcher, L. H. (2004) · Immunity · doi:10.1016/s1074-7613(04)00076-7 · Cited by 722
The trafficking of natural killer cells
Grégoire, C., Chasson, L., Luci, C., Tomasello, E., Geissmann, F., Vivier, E., & Walzer, T. (2007) · Immunological Reviews · doi:10.1111/j.1600-065x.2007.00563.x · Cited by 569
NATURAL KILLER CELL DEVELOPMENTAL PATHWAYS: A Question of Balance
Di Santo, J. P. (2006) · Annual Review of Immunology · doi:10.1146/annurev.immunol.24.021605.090700 · Cited by 448
Self-citationA pan-cancer single-cell panorama of human natural killer cells
Tang, F., Li, J., Qi, L., Liu, D., Bo, Y., Qin, S., Miao, Y., Yu, K., Hou, W., Li, J., et al. (2023) · Cell · doi:10.1016/j.cell.2023.07.034 · Cited by 450
“of NK cells and utilized for NK cell infusion and in vitro propagation.(4,68) By contrast, TIGIT contributes to suppressing NK cellmediated immune responses as an inhibitory receptor.”
Background
Metadata
- Authors
- Ranson, T., Vosshenrich, C. A. J., Corcuff, E., Richard, O., Müller, W., & Di Santo, J. P.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2003-06-15
- Volume
- 101
- Issue
- 12
- Pages
- 4887-4893
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2033223710
- Cited by
- 342
- References
- 34
- FWCI
- 4.68
- Type
- journal article
- Language
- en
- Open access
- bronze
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