The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Highly efficient endosomal labeling of progenitor and stem cells with large magnetic particles allows magnetic resonance imaging of single cells
Open accessAbstract
Tracking transplanted stem cells using magnetic resonance imaging (MRI) could offer biologic insight into homing and engraftment. Ultrasmall dextran-coated iron oxide particles have previously been developed for uptake into cells to allow MRI tracking. We describe a new application of much larger, micron-scale, iron oxide magnetic particles with enhanced MR susceptibility, which enables detection of single cells at resolutions that can be achieved in vivo. In addition, these larger particles possess a fluorophore for histologic confirmation of cell distribution. We demonstrate highly efficient, nontoxic, endosomal uptake of these particles into hematopoietic CD34+ cells and mesenchymal stem cells documented by confocal and electron microscopy. Labeled cells retain biologic activity with preservation of colony-forming ability and differentiation capacity. MRI studies could detect labeled CD34+ cells and mesenchymal stem cells (MSCs) at single cell resolution. This appears to be a promising tool for serial noninvasive monitoring of in vivo cell homing and localization using MRI.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Multilineage potential of adult human mesenchymal stem cells
Pittenger, M. F., Mackay, A. M., Beck, S. C., Jaiswal, R. K., Douglas, R., Mosca, J. D., Moorman, M. A., Simonetti, D. W., Craig, S., & Marshak, D. R. (1999) · Science · doi:10.1126/science.284.5411.143 · Cited by 21,052
Cited by
Iron oxide MR contrast agents for molecular and cellular imaging
Bulte, J. W. M., & Kraitchman, D. L. (2004) · NMR in Biomedicine · doi:10.1002/nbm.924 · Cited by 1,500
Superparamagnetic Iron Oxide Nanoparticle Probes for Molecular Imaging
Thorek, D. L. J., Chen, A. K., Czupryna, J., & Tsourkas, A. (2006) · Annals of Biomedical Engineering · doi:10.1007/s10439-005-9002-7 · Cited by 772
Mesenchymal Stem Cells: Isolation and Therapeutics
Alhadlaq, A., & Mao, J. J. (2004) · Stem Cells and Development · doi:10.1089/1547328041797552 · Cited by 560
Serial Cardiac Magnetic Resonance Imaging of Injected Mesenchymal Stem Cells
Hill, J. M., Dick, A. J., Raman, V. K., Thompson, R. B., Yu, Z.-X., Hinds, K. A., Pessanha, B. S. S., Guttman, M. A., Varney, T. R., Martin, B. J., et al. (2003) · Circulation · doi:10.1161/01.cir.0000084537.66419.7a · Cited by 458
Self-citationLange, C., Tögel, F., Ittrich, H., Clayton, F., Nolte-Ernsting, C., Zander, A. R., & Westenfelder, C. (2005) · Kidney International · doi:10.1111/j.1523-1755.2005.00573.x · Cited by 414
Metadata
- Authors
- Hinds, K. A., Hill, J. M., Shapiro, E. M., Laukkanen, M. O., Silva, A. C., Combs, C. A., Varney, T. R., Balaban, R. S., Koretsky, A. P., & Dunbar, C. E.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2003-08-01
- Volume
- 102
- Issue
- 3
- Pages
- 867-872
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W1976721556
- Cited by
- 401
- References
- 1
- FWCI
- 27.41
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Highly efficient endosomal labeling of progenitor and stem cells with large magnetic particles allows magnetic resonance imaging of single cells. https://app.cochat.ai/papers/10.1182/blood-2002-12-3669
- The paper
- Hinds, K. A., Hill, J. M., Shapiro, E. M., Laukkanen, M. O., Silva, A. C., Combs, C. A., Varney, T. R., Balaban, R. S., Koretsky, A. P., & Dunbar, C. E. (2003). Highly efficient endosomal labeling of progenitor and stem cells with large magnetic particles allows magnetic resonance imaging of single cells. Blood. https://doi.org/10.1182/blood-2002-12-3669
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
