The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Serial Cardiac Magnetic Resonance Imaging of Injected Mesenchymal Stem Cells
Open accessAbstract
Background— Delivery and tracking of endomyocardial stem cells are limited by the inability to image transplanted cells noninvasively in the beating heart. We hypothesized that mesenchymal stem cells (MSCs) could be labeled with a iron fluorophore particle (IFP) to provide MRI contrast in vivo to assess immediate and long-term localization. Methods and Results— MSCs were isolated from swine. Short-term incubation of MSCs with IFP resulted in dose-dependent and efficient labeling. Labeled cells remained viable for multiple passages and retained in vitro proliferation and differentiation capacity. Labeled MSCs (10 4 to 10 6 cells/150 μL) were injected percutaneously into normal and freshly infarcted myocardium in swine. One, 3, and 1 animals underwent serial cardiac MRI (1.5T) for 4, 8, and 21 days, respectively. MRI contrast properties were measured both in vivo and in vitro for cells embedded in agar. Injection sites containing as few as 10 5 MSCs could be detected and contained intact IFP-bearing MSCs on histology. Conclusions— IFP labeling of MSCs imparts useful MRI contrast, enabling ready detection in the beating heart on a conventional cardiac MR scanner after transplantation into normal and infarcted myocardium. The dual-labeled MSCs can be identified at locations corresponding to injection sites, both ex vivo using fluorescence microscopy and in vivo using susceptibility contrast on MRI. This technology may permit effective in vivo study of stem cell retention, engraftment, and migration.
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Multilineage potential of adult human mesenchymal stem cells
Pittenger, M. F., Mackay, A. M., Beck, S. C., Jaiswal, R. K., Douglas, R., Mosca, J. D., Moorman, M. A., Simonetti, D. W., Craig, S., & Marshak, D. R. (1999) · Science · doi:10.1126/science.284.5411.143 · Cited by 21,052
Human Mesenchymal Stem Cells Differentiate to a Cardiomyocyte Phenotype in the Adult Murine Heart
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Cardiomyocytes can be generated from marrow stromal cells in vitro
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Magnetodendrimers allow endosomal magnetic labeling and in vivo tracking of stem cells
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Hinds, K. A., Hill, J. M., Shapiro, E. M., Laukkanen, M. O., Silva, A. C., Combs, C. A., Varney, T. R., Balaban, R. S., Koretsky, A. P., & Dunbar, C. E. (2003) · Blood · doi:10.1182/blood-2002-12-3669 · Cited by 401
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Cited by
Iron oxide MR contrast agents for molecular and cellular imaging
Bulte, J. W. M., & Kraitchman, D. L. (2004) · NMR in Biomedicine · doi:10.1002/nbm.924 · Cited by 1,500
de Vries, I. J. M., Lesterhuis, W. J., Barentsz, J. O., Verdijk, P., van Krieken, J. H., Boerman, O. C., Oyen, W. J. G., Bonenkamp, J. J., Boezeman, J. B., Adema, G. J., et al. (2005) · Nature Biotechnology · doi:10.1038/nbt1154 · Cited by 821
Lange, C., Tögel, F., Ittrich, H., Clayton, F., Nolte-Ernsting, C., Zander, A. R., & Westenfelder, C. (2005) · Kidney International · doi:10.1111/j.1523-1755.2005.00573.x · Cited by 414
Murry, C. E., Reinecke, H., & Pabon, L. M. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.02.002 · Cited by 360
Biocompatibility and Toxicity of Magnetic Nanoparticles in Regenerative Medicine
Markides, H., Rotherham, M., & El Haj, A. J. (2012) · Journal of Nanomaterials · doi:10.1155/2012/614094 · Cited by 332
Metadata
- Authors
- Hill, J. M., Dick, A. J., Raman, V. K., Thompson, R. B., Yu, Z.-X., Hinds, K. A., Pessanha, B. S. S., Guttman, M. A., Varney, T. R., Martin, B. J., Dunbar, C. E., McVeigh, E. R., & Lederman, R. J.
- Venue
- Circulation
- Published
- 2003-08-26
- Volume
- 108
- Issue
- 8
- Pages
- 1009-1014
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2120666169
- Cited by
- 458
- References
- 18
- FWCI
- 19.58
- Type
- journal article
- Language
- en
- Open access
- green
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- Hill, J. M., Dick, A. J., Raman, V. K., Thompson, R. B., Yu, Z.-X., Hinds, K. A., Pessanha, B. S. S., Guttman, M. A., Varney, T. R., Martin, B. J., Dunbar, C. E., McVeigh, E. R., & Lederman, R. J. (2003). Serial Cardiac Magnetic Resonance Imaging of Injected Mesenchymal Stem Cells. Circulation. https://doi.org/10.1161/01.cir.0000084537.66419.7a
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