The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Hsp27 inhibits release of mitochondrial protein Smac in multiple myeloma cells and confers dexamethasone resistance
Abstract
Smac, second mitochondria-derived activator of caspases, promotes apoptosis via activation of caspases. Heat shock protein 27 (Hsp27) negatively regulates another mitochondrial protein, cytochrome c, during apoptosis; however, the role of Hsp27 in modulating Smac release is unknown. Here we show that Hsp27 is overexpressed in both dexamethasone (Dex)-resistant multiple myeloma (MM) cell lines (MM.1R, U266, RPMI-8226) and primary patient cells. Blocking Hsp27 by an antisense (AS) strategy restores the apoptotic response to Dex in Dex-resistant MM cells by triggering the release of mitochondrial protein Smac, followed by activation of caspase-9 and caspase-3. Moreover, AS-Hsp27 overcomes interleukin-6 (IL-6)-mediated protection against Dex-induced apoptosis. These data demonstrate that Hsp27 inhibits the release of Smac, and thereby confers Dex resistance in MM cells.
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Citations
Cites
On the role of Hsp27 in regulating apoptosis
Concannon, C. G., Gorman, A. M., & Samali, A. (2003) · Apoptosis · doi:10.1023/a:1021601103096 · Cited by 513
Cited by
Cellular Stress Responses: Cell Survival and Cell Death
Fulda, S., Gorman, A. M., Hori, O., & Samali, A. (2010) · International Journal of Cell Biology · doi:10.1155/2010/214074 · Cited by 1,519
`The stress of dying': the role of heat shock proteins in the regulation of apoptosis
Beere, H. M. (2004) · Journal of Cell Science · doi:10.1242/jcs.01284 · Cited by 639
Intracellular and extracellular functions of heat shock proteins: repercussions in cancer therapy
Schmitt, E., Gehrmann, M., Brunet, M., Multhoff, G., & Garrido, C. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.0306167 · Cited by 573
Neuronal cell death in neurodegenerative diseases: recurring themes around protein handling
Gorman, A. M. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00402.x · Cited by 362
Acunzo, J., Katsogiannou, M., & Rocchi, P. (2012) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2012.04.002 · Cited by 280
Metadata
- Authors
- Chauhan, D., Li, G., Hideshima, T., Podar, K., Mitsiades, C., Mitsiades, N., Catley, L., Tai, Y. T., Hayashi, T., Shringarpure, R., Burger, R., Munshi, N., Ohtake, Y., Saxena, S., & Anderson, K. C.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2003-11-01
- Volume
- 102
- Issue
- 9
- Pages
- 3379-3386
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2169210465
- Cited by
- 158
- References
- 1
- FWCI
- 5.52
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Chauhan, D., Li, G., Hideshima, T., Podar, K., Mitsiades, C., Mitsiades, N., Catley, L., Tai, Y. T., Hayashi, T., Shringarpure, R., Burger, R., Munshi, N., Ohtake, Y., Saxena, S., & Anderson, K. C. (2003). Hsp27 inhibits release of mitochondrial protein Smac in multiple myeloma cells and confers dexamethasone resistance. Blood. https://doi.org/10.1182/blood-2003-05-1417
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