Neuronal cell death in neurodegenerative diseases: recurring themes around protein handling

Gorman, Adrienne M.

doi:10.1111/j.1582-4934.2008.00402.x

Cited by 363Cell death mechanisms and regulationAutophagy in Disease and TherapyNeuroinflammation and Neurodegeneration Mechanisms

Neuronal cell death in neurodegenerative diseases: recurring themes around protein handling

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Gorman, Adrienne M.·2008·Journal of Cellular and Molecular Medicine

DOI 10.1111/j.1582-4934.2008.00402.xPMC PMC4514105

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Abstract

Neuronal cell death plays a role in many chronic neurodegenerative diseases with the loss of particular subsets of neurons. The loss of the neurons occurs during a period of many years, which can make the mode(s) of cell death and the initiating factors difficult to determine. In vitro and in vivo models have proved invaluable in this regard, yielding insight into cell death pathways. This review describes the main mechanisms of neuronal cell death, particularly apoptosis, necrosis, excitotoxicity and autophagic cell death, and their role in neurodegenerative diseases such as ischaemia, Alzheimer's, Parkinson's and Huntington's diseases. Crosstalk between these death mechanisms is also discussed. The link between cell death and protein mishandling, including misfolded proteins, impairment of protein degradation, protein aggregation is described and finally, some pro‐survival strategies are discussed.

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AD is a neurodegenerative disorder marked by neuronal loss, especially in the hippocampus and cerebral cortex.
“AD is a neurodegenerative disorder marked by neuronal loss, especially in the hippocampus and cerebral cortex (49, 50).”
From Modeling late-onset Alzheimer’s disease neuropathology via direct neuronal reprogramming (2024) · cites this paper as [50]
The Introduction identifies AD as a neurodegenerative disease, and the Alzheimer’s disease section describes neuronal loss in hippocampal regions. The paper does not state that neuronal loss is especially prominent in the cerebral cortex generally, although its references mention loss of entorhinal cortex neurons. Page numbers are unavailable in our copy. (LLM, conf=0.84)
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[9]Luetjens CM Bui NT Sengpiel B Munstermann G Poppe M Krohn AJ Bauerbach E Krieglstein J Prehn JH Delayed mitochondrial dysfunction in exci-totoxic neuron death: cytochrome c release and a secondary increase in super-oxide production J Neurosci 2000 20 5715 23 10908611 PMC6772544
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[202]Samali A Robertson JD Peterson E Manero F van Zeijl L Paul C Cotgreave IA Arrigo AP Orrenius S Hsp27 protects mitochondria of thermotolerant cells against apoptotic stimuli Cell Stress Chaperones 2001 6 49 58 11525243 PMC434383

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Neuronal cell death in neurodegenerative diseases: Recurring themes around protein handling: Apoptosis Review Series
Gorman, A. M. (2008) · ARAN (University of Galway Research Repository) (Ollscoil na Gaillimhe – University of Galway) · doi:10.13025/15409
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Neuronal cell death in neurodegenerative diseases: Recurrent themes around protein handling
Gorman, A. M. (2008)
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Authors: Gorman, A. M.
Affiliations: Ollscoil na Gaillimhe – University of Galway (IE)
Corresponding author: Gorman, Adrienne M.
ORCID: Gorman, Adrienne M.
Venue: Journal of Cellular and Molecular Medicine
Publisher: Wiley
Published: 2008-07-10
Volume: 12
Issue: 6a
Pages: 2263-2280
ISSN: 1582-1838 (ISSN-L)
1582-4934
DOI: 10.1111/j.1582-4934.2008.00402.x
PMC: PMC4514105
OpenAlex: W1965453486
Cited by: 362
References: 222
Citations by year: 2026: 18 · 2025: 28 · 2024: 35 · 2023: 34 · 2022: 38 · 2021: 36 · 2020: 11 · 2019: 26 · 2018: 28 · 2017: 26 · 2016: 11 · 2015: 6 · 2014: 8 · 2013: 9 · 2012: 10
FWCI: 0.98
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
doi.wiley.com/10.1002/tdm_license_1.1 (tdm)
Locations: Journal of Cellular and Molecular Medicine (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Arrow@dit (Dublin Institute of Technology) (acceptedVersion)
ARAN (University of Galway Research Repository) (Ollscoil na Gaillimhe – University of Galway) (acceptedVersion, cc-by-nc-nd)
ARAN (University of Galway Research Repository) (Ollscoil na Gaillimhe – University of Galway) (submittedVersion, cc-by-nc-nd)
Arrow@dit (Dublin Institute of Technology) (submittedVersion, cc-by-nc-nd)
Research Repository UCD (University College Dublin) (cc-by)
Funders: National University of Ireland
University of Galway
Irish Research Council
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: neuronal cell death, neurodegenerative diseases, apoptosis, necrosis, excitotoxicity, autophagic cell death, protein misfolding, protein aggregation, protein degradation, ischemia, Alzheimer's disease, Parkinson's disease, Huntington's disease, neuroprotection
MeSH terms: Alzheimer Disease, Autophagy, Brain Ischemia, Endoplasmic Reticulum, Humans, Huntington Disease, Models, Neurological, Necrosis, Nerve Tissue Proteins, Neurons, Parkinson Disease, Stress, Physiological, Receptors, N-Methyl-D-Aspartate, Cell Death, Apoptosis, Neurodegenerative Diseases, Ubiquitin, Proteasome Endopeptidase Complex

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Neuronal cell death in neurodegenerative diseases: recurring themes around protein handling

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