The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Female donors contribute to a selective graft-versus-leukemia effect in male recipients of HLA-matched, related hematopoietic stem cell transplants
Open accessAbstract
Male recipients of transplants from female (F→M) hematopoietic stem cell donors represent a special group in whom donor T cells that are specific for recipient minor histocompatibility antigens encoded by Y-chromosome genes may contribute to a graft-versus-leukemia (GVL) effect and to graft-versus-host disease (GVHD). We examined the contribution of donor/patient sex to the risk for relapse and GVHD in 3238 patients who underwent HLA-identical sibling hematopoietic stem cell transplantation (HSCT) for hematopoietic malignancies at a single institution. Compared with other sex combinations, male recipients of female transplants had the lowest risk for relapse and the greatest odds for GVHD. Remarkably, after controlling for GVHD as a time-dependent covariate, F→M HSCT still exhibited a lower risk for relapse than other sex combinations, demonstrating a selective GVL effect distinct from that contributed by GVHD. A reduction in relapse after F→M HSCT was observed in patients with chronic myelogenous leukemia (CML), acute myelogenous leukemia (AML), and acute lymphoblastic leukemia (ALL). Taken together, these data suggest that minor H antigens encoded or regulated by genes on the Y chromosome contribute to a selective GVL effect against myeloid and lymphoid leukemias after F→M HSCT.
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Cites
1994 Consensus Conference on Acute GVHD Grading.
Przepiorka, D., Weisdorf, D., Martin, P., Hg, K., Beatty, P., Hows, J., & Thomas, E. D. (1995) · PubMed · Cited by 5,037
Graft-versus-leukemia reactions after bone marrow transplantation
Horowitz, M., Gale, R., Sondel, P., Goldman, J., Kersey, J., Kolb, H., Rimm, A., Ringden, O., Rozman, C., & Speck, B. (1990) · Blood · doi:10.1182/blood.v75.3.555.555 · Cited by 2,774
Kolb, H., Schattenberg, A., Goldman, J., Hertenstein, B., Jacobsen, N., Arcese, W., Ljungman, P., Ferrant, A., Verdonck, L., & Niederwieser, D. (1995) · Blood · doi:10.1182/blood.v86.5.2041.bloodjournal8652041 · Cited by 1,934
Antileukemic Effect of Graft-versus-Host Disease in Human Recipients of Allogeneic-Marrow Grafts
Weiden, P. L., Flournoy, N., Thomas, E. D., Prentice, R., Fefer, A., Buckner, C. D., & Storb, R. (1979) · New England Journal of Medicine · doi:10.1056/nejm197905103001902 · Cited by 1,510
McSweeney, P. A., Niederwieser, D., Shizuru, J. A., Sandmaier, B. M., Molina, A. J., Maloney, D. G., Chauncey, T. R., Gooley, T. A., Hegenbart, U., Nash, R. A., et al. (2001) · Blood · doi:10.1182/blood.v97.11.3390 · Cited by 1,389
Self-citationCollins, R. H., Shpilberg, O., Drobyski, W. R., Porter, D. L., Giralt, S., Champlin, R., Goodman, S. A., Wolff, S. N., Hu, W., Verfaillie, C., et al. (1997) · Journal of Clinical Oncology · doi:10.1200/jco.1997.15.2.433 · Cited by 1,237
Weiden, P. L., Sullivan, K. M., Flournoy, N., Storb, R., Thomas, E. D., & The Seattle Marrow Transplant Team (1981) · New England Journal of Medicine · doi:10.1056/nejm198106183042507 · Cited by 1,081
Khouri, I. F., Keating, M., Körbling, M., Przepiorka, D., Anderlini, P., O'Brien, S., Giralt, S., Ippoliti, C., von Wolff, B., Gajewski, J., et al. (1998) · Journal of Clinical Oncology · doi:10.1200/jco.1998.16.8.2817 · Cited by 919
Sullivan, K., Weiden, P., Storb, R., Witherspoon, R., Fefer, A., Fisher, L., Buckner, C., Anasetti, C., Appelbaum, F., & Badger, C. (1989) · Blood · doi:10.1182/blood.v73.6.1720.1720 · Cited by 599
Self-citationMielcarek, M., Martin, P. J., Leisenring, W., Flowers, M. E. D., Maloney, D. G., Sandmaier, B. M., Maris, M. B., & Storb, R. (2003) · Blood · doi:10.1182/blood-2002-08-2628 · Cited by 562
Cited by
Hematopoietic Stem-Cell Transplantation
Copelan, E. A. (2006) · New England Journal of Medicine · doi:10.1056/nejmra052638 · Cited by 2,522
Miklos, D. B., Kim, H. T., Miller, K. H., Guo, L., Zorn, E., Lee, S. J., Hochberg, E. P., Wu, C. J., Alyea, E. P., Cutler, C., et al. (2005) · Blood · doi:10.1182/blood-2004-09-3660 · Cited by 406
Who is the best donor for a related HLA haplotype-mismatched transplant?
Wang, Y., Chang, Y.-J., Xu, L.-P., Liu, K.-Y., Liu, D.-H., Zhang, X.-H., Chen, H., Han, W., Chen, Y.-H., Wang, F.-R., et al. (2014) · Blood · doi:10.1182/blood-2014-03-563130 · Cited by 344
Chronic graft-versus-host disease. Part I: Epidemiology, pathogenesis, and clinical manifestations
Baumrin, E., Loren, A. W., Falk, S. J., Mays, J. W., & Cowen, E. W. (2024) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2022.12.024 · Cited by 59
Retracted
Metadata
- Authors
- Randolph, S. S. B., Gooley, T. A., Warren, E. H., Appelbaum, F. R., & Riddell, S. R.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2004-01-01
- Volume
- 103
- Issue
- 1
- Pages
- 347-352
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2005302631
- Cited by
- 260
- References
- 27
- FWCI
- 6.94
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Randolph, S. S. B., Gooley, T. A., Warren, E. H., Appelbaum, F. R., & Riddell, S. R. (2004). Female donors contribute to a selective graft-versus-leukemia effect in male recipients of HLA-matched, related hematopoietic stem cell transplants. Blood. https://doi.org/10.1182/blood-2003-07-2603
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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