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Taming platelets with cyclic nucleotides11Abbreviations: ABP, actin binding protein; AC, adenylyl cyclase; cAMP, cyclic AMP; cAMP-PK, cAMP-dependent protein kinase; cGMP, cyclic GMP; cGMP-PK, cGMP-dependent protein kinase; DAG, 1,2-diacylglycerol; EDRF, endothelium-derived relaxing factor; GC, guanylyl cyclase; GP, glycoprotein; Hsp27, heat shock protein 27; IP3, inositol 1,4,5- trisphosphate; IRAG, IP3 receptor-associated cGMP-PK substrate; MAPK, mitogen-activated protein kinase; MAPKAPK-2, MAPK-activated protein kinase-2; MARCKS, myristoylated alanine-rich C kinase substrate; MLC, myosin light chain; MLCK, myosin light chain kinase; PDE, phosphodiesterase; PG-E1, prostaglandin E1; PG-I2, prostacyclin; PIP2, phosphatidylinositol 4,5-bisphosphate; PKC, protein kinase C; PLC, phospholipase C; TxA2, thromboxane A2, and VASP, vasodilator-stimulated phosphoprotein.

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Platelet Hemostasis Reactions at Different Temperatures Correlate with Intracellular Calcium Concentration

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Multifaceted effects of arachidonic acid and interaction with cyclic nucleotides in human platelets

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Insulin inhibition of platelet‐endothelial interaction is mediated by insulin effects on endothelial cells without direct effects on platelets

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Sildenafil Improves Coronary Artery Patency in a Canine Model of Platelet-Mediated Cyclic Coronary Occlusion After Thrombolysis

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The oligopeptide DT‐2 is a specific PKG I inhibitor only in vitro, not in living cells

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Curcumin at Low Doses Potentiates and at High Doses Inhibits ABT-737-Induced Platelet Apoptosis

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Echicetin Coated Polystyrene Beads: A Novel Tool to Investigate GPIb-Specific Platelet Activation and Aggregation

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Cyclic nucleotides inhibit MAP kinase activity in low-dose collagen-stimulated platelets

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The thrombin inhibitors hirudin and Refludan® activate the soluble guanylyl cyclase and the cGMP pathway in washed human platelets

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Regulation of the renin-angiotensin-aldosterone system by cyclic nucleotides and phosphodiesterases

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Activation of Protein Kinase G (PKG) Reduces Neointimal Hyperplasia, Inhibits Platelet Aggregation, and Facilitates Re-endothelialization

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On the roles of cGMP and glycoprotein Ib in platelet activation

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Relation of hemoglobin level to no-reflow in patients with ST-segment elevation myocardial infarction undergoing primary coronary intervention

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2-Methoxybenzoic acid ameliorates arterial thrombosis via inhibiting carbon anhydrase activity in platelet

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Potential and limitations of PKA/ PKG inhibitors for platelet studies

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NO/cGMP and ROS Pathways in Regulation of Platelet Function and Megakaryocyte Maturation

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Cyclic Nucleotide Specificity and Cross-Activation of Cyclic Nucleotide Receptors

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Cyclic GMP modulates store-operated calcium entry inducing phosphatidylserine translocation at the surface of megakaryocytic cells

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NADPH oxidase 2 inhibitor GSK2795039 exerts antiplatelet and antithrombotic activity

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Thrombin-induced platelet inhibition by 2′,4′-dihydroxychalcone and 2′,4′-dihydroxydihydrochalcone is mediated by inhibition of ROS production and Thromboxane synthase a activity: structure-activity relationship of polyphenol secondary metabolites from Empetrum nigrum

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Lighting up kinase action in platelets

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Specific PKG inhibitors: do they really exist?

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Response: yes, cGMP plays a stimulatory role in platelet activation

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Peri-operative Decreased cAMP Levels in Long-term Alcoholic Patients

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cGMP and PKG Signaling in Platelets

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Regulation von Plättchenfunktion durch Epac-Proteine

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Functional role of cGMP-dependent VASP phosphorylation in vascular cells

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Roles of cGMP/cGMP-dependent protein kinase in platelet activation

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Time-dependent inhibitory effects of cGMP-analogues on thrombin-induced platelet-derived microparticles formation, platelet aggregation, and P-selectin expression

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Inhibition of platelet P2Y12 and α2A receptor signaling by cGMP-dependent protein kinase

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cGMP Signaling in Platelets

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NO/cGMP/PKG pathway in platelets: inhibitory but not stimulatory

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