The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Association of Foxp3 regulatory gene expression with graft-versus-host disease
Abstract
Graft-versus-host disease (GVHD) is characterized by an impairment of mechanisms that underlie the development of immunologic tolerance. Although the cytokine storm associated with GVHD leads to expression of cell surface markers on both effector and regulatory T cells, regulatory CD4+ T cells that play an instrumental role in the maintenance of tolerance appear to uniquely express the Foxp3 transcriptional repressor. Foxp3 mRNA expression was significantly decreased in peripheral blood mononuclear cells from patients with either allogeneic GVHD or autologous GVHD compared with patients without GVHD. Expression of Foxp3 negatively correlated with the severity of GVHD but positively correlated with recent thymic emigrants. The results suggest that defective thymic function contributes to the impaired reconstitution of immune regulatory mechanisms following transplantation. The decrease in regulatory mechanisms after transplantation appears to provide an environment permissive to the development of GVHD. (Blood. 2004;104:2187-2193)
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Cites
Control of Regulatory T Cell Development by the Transcription Factor Foxp3
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Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
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Changes in thymic function with age and during the treatment of HIV infection
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Antileukemic Effect of Graft-versus-Host Disease in Human Recipients of Allogeneic-Marrow Grafts
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Cited by
Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression
Wan, Y. Y., & Flavell, R. A. (2007) · Nature · doi:10.1038/nature05479 · Cited by 854
D’Alessio, F. R., Tsushima, K., Aggarwal, N. R., West, E. E., Willett, M. H., Britos, M. F., Pipeling, M. R., Brower, R. G., Tuder, R. M., McDyer, J. F., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci36498 · Cited by 564
Kakihana, K., Fujioka, Y., Suda, W., Najima, Y., Kuwata, G., Sasajima, S., Mimura, I., Morita, H., Sugiyama, D., Nishikawa, H., et al. (2016) · Blood · doi:10.1182/blood-2016-05-717652 · Cited by 367
Kanakry, C. G., Ganguly, S., Zahurak, M., Bolaños-Meade, J., Thoburn, C., Perkins, B., Fuchs, E. J., Jones, R. J., Hess, A. D., & Luznik, L. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3006960 · Cited by 357
Self-citationOutcomes of acute leukemia patients transplanted with naive T cell–depleted stem cell grafts
Bleakley, M., Heimfeld, S., Loeb, K. R., Jones, L. A., Chaney, C., Seropian, S., Gooley, T. A., Sommermeyer, F., Riddell, S. R., & Shlomchik, W. D. (2015) · Journal of Clinical Investigation · doi:10.1172/jci81229 · Cited by 268
Metadata
- Authors
- Miura, Y., Thoburn, C. J., Bright, E. C., Phelps, M. L., Shin, T., Matsui, E. C., Matsui, W. H., Arai, S., Fuchs, E. J., Vogelsang, G. B., Jones, R. J., & Hess, A. D.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2004-10-01
- Volume
- 104
- Issue
- 7
- Pages
- 2187-2193
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2132289468
- Cited by
- 320
- References
- 33
- FWCI
- 15.29
- Type
- journal article
- Language
- en
- Open access
- closed
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- Miura, Y., Thoburn, C. J., Bright, E. C., Phelps, M. L., Shin, T., Matsui, E. C., Matsui, W. H., Arai, S., Fuchs, E. J., Vogelsang, G. B., Jones, R. J., & Hess, A. D. (2004). Association of Foxp3 regulatory gene expression with graft-versus-host disease. Blood. https://doi.org/10.1182/blood-2004-03-1040
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