The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
The CD28 family: a T-cell rheostat for therapeutic control of T-cell activation
Abstract
The CD28 family of receptors (CD28, cytotoxic T-lymphocyte–associated antigen 4 [CTLA-4], inducible costimulator [ICOS], program death-1 [PD-1], and B- and T-lymphocyte attenuator [BTLA]) plays a critical role in controlling the adaptive arm of the immune response. While considerable information is available regarding CD28 and CTLA-4, the function of the more recently discovered members of the CD28 family is less well understood. This review will highlight recent findings regarding the CD28 family with special emphasis on effects the CD28 family has on immunopathology, the discovery of costimulatory antibodies with superagonist function, and the status of clinical trials using various strategies to augment or block T-cell costimulation.
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Citations
Cites
PD-L2 is a second ligand for PD-1 and inhibits T cell activation
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BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1
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Molecular Basis of T Cell Inactivation by CTLA-4
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Cited by
CTLA-4 and PD-1 Receptors Inhibit T-Cell Activation by Distinct Mechanisms
Parry, R. V., Chemnitz, J. M., Frauwirth, K. A., Lanfranco, A. R., Braunstein, I., Kobayashi, S. V., Linsley, P. S., Thompson, C. B., & Riley, J. L. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.21.9543-9553.2005 · Cited by 1,931
Self-citationPD-1 signaling in primary T cells
Riley, J. L. (2009) · Immunological Reviews · doi:10.1111/j.1600-065x.2009.00767.x · Cited by 778
“We and many others have shown that the main targets of negative regulators of T-cell activation are cell growth and metabolism (13, 15, 39, 83).”
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Aldinucci, D., Gloghini, A., Pinto, A., De Filippi, R., & Carbone, A. (2010) · The Journal of Pathology · doi:10.1002/path.2711 · Cited by 275
Metadata
- Authors
- Riley, J. L., & June, C. H.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2005-01-01
- Volume
- 105
- Issue
- 1
- Pages
- 13-21
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2088313410
- Cited by
- 315
- References
- 14
- FWCI
- 8.34
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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