The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Scl is required for dorsal aorta as well as blood formation in zebrafish embryos
Abstract
Blood and endothelial cells arise in close association in developing embryos, possibly from a shared precursor, the hemangioblast, or as hemogenic endothelium. The transcription factor, Scl/Tal1 (stem cell leukemia protein), is essential for hematopoiesis but thought to be required only for remodeling of endothelium in mouse embryos. By contrast, it has been implicated in hemangioblast formation in embryoid bodies. To resolve the role of scl in endothelial development, we knocked down its synthesis in zebrafish embryos where early precursors and later phenotypes can be more easily monitored. With respect to blood, the zebrafish morphants phenocopied the mouse knockout and positioned scl in the genetic hierarchy. Importantly, endothelial development was also clearly disrupted. Dorsal aorta formation was substantially compromised and gene expression in the posterior cardinal vein was abnormal. We conclude that scl is especially critical for the development of arteries where adult hematopoietic stem cells emerge, implicating scl in the formation of hemogenic endothelium.
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Cites
Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice
Shalaby, F., Rossant, J., Yamaguchi, T. P., Gertsenstein, M., Wu, X.-F., Breitman, M. L., & Schuh, A. C. (1995) · Nature · doi:10.1038/376062a0 · Cited by 3,931
Wang, Q., Stacy, T., Binder, M., Marin-Padilla, M., Sharpe, A. H., & Speck, N. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.8.3444 · Cited by 1,178
Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL
Shivdasani, R. A., Mayer, E. L., & Orkin, S. H. (1995) · Nature · doi:10.1038/373432a0 · Cited by 938
Cbfa2 is required for the formation of intra-aortic hematopoietic clusters
North, T., Gu, T.-L., Stacy, T., Wang, Q., Howard, L., Binder, M., Marín-Padilla, M., & Speck, N. A. (1999) · Development · doi:10.1242/dev.126.11.2563 · Cited by 662
Absence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene.
Robb, L., Lyons, I., Li, R., Hartley, L., Köntgen, F., Harvey, R. P., Metcalf, D., & Begley, C. G. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.15.7075 · Cited by 577
Mikkola, H. K. A., Klintman, J., Yang, H., Hock, H., Schlaeger, T. M., Fujiwara, Y., & Orkin, S. H. (2003) · Nature · doi:10.1038/nature01345 · Cited by 371
Cited by
Transcriptional Control of Endothelial Cell Development
De Val, S., & Black, B. L. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.01.014 · Cited by 346
“…development of hematopoietic, endothelial, and neuronal precursor cells, and disruption of Tal1 in either mouse or zebrafish results in severe defects in the development of the vascular system (Green et al., 1992; Kallianpur et al., 1994; Patterson et al., 2005; Visvader et al., 1998; Figure 2).”
BackgroundJagannathan-Bogdan, M., & Zon, L. I. (2013) · Development · doi:10.1242/dev.083147 · Cited by 346
Genetic regulatory networks programming hematopoietic stem cells and erythroid lineage specification
Swiers, G., Patient, R., & Loose, M. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.02.051 · Cited by 168
Self-citationSCL/TAL1: a multifaceted regulator from blood development to disease
Porcher, C., Chagraoui, H., & Kristiansen, M. S. (2017) · Blood · doi:10.1182/blood-2016-12-754051 · Cited by 135
Metadata
- Authors
- Patterson, L. J., Gering, M., & Patient, R.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2005-05-01
- Volume
- 105
- Issue
- 9
- Pages
- 3502-3511
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2048981903
- Cited by
- 164
- References
- 6
- FWCI
- 6.93
- Type
- journal article
- Language
- en
- Open access
- closed
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