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HB-EGF/HER-1 signaling in bone marrow mesenchymal stem cells: inducing cell expansion and reversibly preventing multilineage differentiation
Open accessAbstract
Epidermal growth factor receptor-1 (EGFR-1/HER-1/ErbB-1) regulates proliferation and cell fate during epidermal development. HER-1 is activated by several EGF-family ligands including heparin-binding epidermal growth factor–like growth factor (HB-EGF), a mitogenic and chemotactic molecule that participates in tissue repair, tumor growth, and other tissue-modeling phenomena, such as angiogenesis and fibrogenesis. We found that mesenchymal stem cells (MSCs), the precursors of different mesenchymal tissues with a role in processes in which HB-EGF is often involved, normally express HER-1, but not HB-EGF itself. Under the effect of HB-EGF, MSCs proliferate more rapidly and persistently, without undergoing spontaneous differentiation. This effect occurs in a dose-dependent fashion, and is specific, direct, and HER-1 mediated, as it is inhibited by anti–HER-1 and anti–HB-EGF blocking antibodies. Moreover, HB-EGF reversibly prevents adipogenic, osteogenic, and chondrogenic differentiation induced with specific media. These data show that HB-EGF/HER-1 signaling is relevant to MSC biology, by regulating both proliferation and differentiation.
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Cites
A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF
Higashiyama, S., Abraham, J. A., Miller, J., Fiddes, J. C., & Klagsbrun, M. (1991) · Science · doi:10.1126/science.1840698 · Cited by 1,127
Cited by
Fate decision of mesenchymal stem cells: adipocytes or osteoblasts?
Chen, Q., Shou, P., Zheng, C., Jiang, M., Cao, G., Yang, Q., Cao, J., Xie, N., Velletri, T., Zhang, X., et al. (2016) · Cell Death & Differentiation · doi:10.1038/cdd.2015.168 · Cited by 1,156
Atashi, F., Modarressi, A., & Pepper, M. S. (2015) · Stem Cells and Development · doi:10.1089/scd.2014.0484 · Cited by 603
Mesenchymal Stromal Cell Homing: Mechanisms and Strategies for Improvement
Ullah, M., Liu, D. D., & Thakor, A. S. (2019) · iScience · doi:10.1016/j.isci.2019.05.004 · Cited by 549
Rauch, A., Seitz, S., Baschant, U., Schilling, A. F., Illing, A., Stride, B., Kirilov, M., Mandic, V., Takacz, A., Schmidt-Ullrich, R., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.05.005 · Cited by 422
Mesenchymal stem cells: characteristics and clinical applications.
Bobis‐Wozowicz, S., Jarocha, D. J., & Majka, M. (2006) · PubMed · doi:10.5603/4554 · Cited by 337
Metadata
- Authors
- Krampera, M., Pasini, A., Rigo, A., Scupoli, M. T., Tecchio, C., Malpeli, G., Scarpa, A., Dazzi, F., Pizzolo, G., & Vinante, F.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2005-07-01
- Volume
- 106
- Issue
- 1
- Pages
- 59-66
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2014129405
- Cited by
- 226
- References
- 1
- FWCI
- 4.31
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: HB-EGF/HER-1 signaling in bone marrow mesenchymal stem cells: inducing cell expansion and reversibly preventing multilineage differentiation. https://app.cochat.ai/papers/10.1182/blood-2004-09-3645
- The paper
- Krampera, M., Pasini, A., Rigo, A., Scupoli, M. T., Tecchio, C., Malpeli, G., Scarpa, A., Dazzi, F., Pizzolo, G., & Vinante, F. (2005). HB-EGF/HER-1 signaling in bone marrow mesenchymal stem cells: inducing cell expansion and reversibly preventing multilineage differentiation. Blood. https://doi.org/10.1182/blood-2004-09-3645
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