The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production
Open accessAbstract
Dectin-1 is a lectin receptor for β-glucan that is important for innate macrophage recognition of fungi and contributes to phagocytosis, reactive oxygen production, and induction of inflammatory cytokines. The mechanisms by which Dectin-1 mediates intracellular signaling are just beginning to be defined. Spleen tyrosine kinase (Syk) is a protein tyrosine kinase that is critical for adaptive immune responses where it mediates signaling through B-cell receptors, T-cell receptors, and Fc receptors. Here we report that Dectin-1 activates Syk in macrophages and is important for Dectin-1-stimulated reactive oxygen production, but not for phagocytosis. Syk activation is restricted to a subpopulation of macrophages that is in equilibrium with cells that cannot activate the pathway. The proportion of macrophages using this signaling pathway can be modulated by cytokine treatment. Thus, Dectin-1 signaling reveals dynamic macrophage heterogeneity in inflammatory activation potential. (Blood. 2005;106:2543-2550)
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Toll-like receptors in innate immunity
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The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens
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REGULATION OF GENE EXPRESSION BY REACTIVE OXYGEN
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Cited by
Pathogen Recognition and Innate Immunity
Akira, S., Uematsu, S., & Takeuchi, O. (2006) · Cell · doi:10.1016/j.cell.2006.02.015 · Cited by 11,952
Innate Immune Pattern Recognition: A Cell Biological Perspective
Brubaker, S. W., Bonham, K. S., Zanoni, I., & Kagan, J. C. (2015) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032414-112240 · Cited by 1,475
Signalling through C-type lectin receptors: shaping immune responses
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The SYK tyrosine kinase: A crucial player in diverse biological functions
Mócsai, A., Ruland, J., & Tybulewicz, V. L. J. (2010) · Nature Reviews Immunology · doi:10.1038/nri2765 · Cited by 1,368
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Metadata
- Authors
- Underhill, D. M., Rossnagle, E., Lowell, C. A., & Simmons, R. M.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2005-10-01
- Volume
- 106
- Issue
- 7
- Pages
- 2543-2550
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W1988822418
- Cited by
- 526
- References
- 41
- FWCI
- 9.66
- Type
- journal article
- Language
- en
- Open access
- green
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