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Cited by 632

The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.

IL-2 administration increases CD4+CD25hi Foxp3+ regulatory T cells in cancer patients

Open access
Ahmadzadeh, Mojgan, Rosenberg, Steven A.·2006·Blood
DOI 10.1182/blood-2005-06-2399
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Abstract

Interleukin-2 (IL-2) is historically known as a T-cell growth factor. Accumulating evidence from knockout mice suggests that IL-2 is crucial for the homeostasis and function of CD4+CD25+ regulatory T cells in vivo. However, the impact of administered IL-2 in an immune intact host has not been studied in rodents or humans. Here, we studied the impact of IL-2 administration on the frequency and function of human CD4+CD25hi T cells in immune intact patients with melanoma or renal cancer. We found that the frequency of CD4+CD25hi T cells was significantly increased after IL-2 treatment, and these cells expressed phenotypic markers associated with regulatory T cells. In addition, both transcript and protein levels of Foxp3, a transcription factor exclusively expressed on regulatory T cells, were consistently increased in CD4 T cells following IL-2 treatment. Functional analysis of the increased number of CD4+CD25hi T cells revealed that this population exhibited potent suppressive activity in vitro. Collectively, our results demonstrate that administration of high-dose IL-2 increased the frequency of circulating CD4+CD25hi Foxp3+ regulatory T cells. Our findings suggest that selective inhibition of IL-2-mediated enhancement of regulatory T cells may improve the therapeutic effectiveness of IL-2 administration. (Blood. 2006;107:2409-2414)

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Metadata

Authors
Ahmadzadeh, M., & Rosenberg, S. A.
Venue
Blood
Publisher
American Society of Hematology
Published
2006-03-15
Volume
107
Issue
6
Pages
2409-2414
ISSN
  • 0006-4971 (ISSN-L)
  • 1528-0020
DOI
10.1182/blood-2005-06-2399
OpenAlex
W1985126564
Cited by
632
References
26
FWCI
13.84
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: IL-2 administration increases CD4+CD25hi Foxp3+ regulatory T cells in cancer patients. https://app.cochat.ai/papers/10.1182/blood-2005-06-2399
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Ahmadzadeh, M., & Rosenberg, S. A. (2006). IL-2 administration increases CD4+CD25hi Foxp3+ regulatory T cells in cancer patients. Blood. https://doi.org/10.1182/blood-2005-06-2399

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