IL-7 administration to humans leads to expansion of CD8+ and CD4+ cells but a relative decrease of CD4+ T-regulatory cells
Open accessAbstract
Lymphopenia is a serious consequence of HIV infection and the administration of cancer chemotherapeutic agents. Although growth factors can be administered to patients to increase circulating neutrophils, there is no effective method to stimulate CD8+ lymphocyte production in humans, in vivo. This report is the first to describe the administration of recombinant interleukin-7 to humans and demonstrates the ability of this cytokine to mediate selective increases in CD4+ and CD8+ lymphocytes along with a decrease in the percentage of CD4+ T-regulatory cells. These studies suggest an important role for interleukin-7 in the treatment of patients with lymphopenia.
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In the first clinical trial in humans, patients with metastatic cancer (age range 20-59 years) treated with different doses of IL-7 showed a dose-dependent increase in circulating CD4+ and CD8+ lymphocytes along with a decrease in Tregs.
“In the first clinical trial in humans, patients with metastatic cancer (age range 20–59 years) treated with different doses of IL-7 showed a dose-dependent increase in circulating CD4+ and CD8+ lymphocytes along with a decrease in Tregs (162).”
From Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention (2019) · cites this paper as [162]
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Cites
Sakaguchi, S. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141122 · Cited by 3,293 · see citing works
Cancer immunotherapy: moving beyond current vaccines
Rosenberg, S. A., Yang, J. C.-H., & Restifo, N. P. (2004) · Nature Medicine · doi:10.1038/nm1100 · Cited by 2,956 · see citing works
Self-citationRosenberg, S. A., Yang, J. C., Schwartzentruber, D. J., Hwu, P., Marincola, F. M., Topalian, S. L., Restifo, N. P., Dudley, M. E., Schwarz, S. L., Spiess, P. J., et al. (1998) · Nature Medicine · doi:10.1038/nm0398-321 · Cited by 1,786 · see citing works
Self-citationEarly lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice.
Peschon, J. J., Morrissey, P., Grabstein, K. H., Ramsdell, F. J., Maraskovsky, E., Gliniak, B., Park, L. S., Ziegler, S. F., Williams, D. E., Ware, C. B., et al. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.180.5.1955 · Cited by 1,553 · see citing works
Defective IL7R expression in T(-)B(+)NK(+) severe combined immunodeficiency
Puel, A., Ziegler, S. F., Buckley, R. H., & Leonard., W. J. (1998) · Nature Genetics · doi:10.1038/3877 · Cited by 813 · see citing works
Antony, P. A., Piccirillo, C. A., Akpınarlı, A., Finkelstein, S. E., Speiss, P. J., Surman, D. R., Palmer, D. C., Chan, C., Klebanoff, C. A., Overwijk, W. W., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.5.2591 · Cited by 754 · see citing works
Self-citationIL-2 administration increases CD4+CD25hi Foxp3+ regulatory T cells in cancer patients
Ahmadzadeh, M., & Rosenberg, S. A. (2005) · Blood · doi:10.1182/blood-2005-06-2399 · Cited by 630 · see citing works
Self-citationInterleukin-7: from bench to clinic
Fry, T. J., & Mackall, C. L. (2002) · Blood · doi:10.1182/blood.v99.11.3892 · Cited by 502 · see citing works
Self-citationKovacs, J. A., Baseler, M., Dewar, R. J., Vogel, S. E., Davey, R. T., Falloon, J., Polis, M. A., WALKER, R. E., Stevens, R. A., Salzman, N. P., et al. (1995) · New England Journal of Medicine · doi:10.1056/nejm199503023320904 · Cited by 422 · see citing works
A potential role for interleukin-7 in T-cell homeostasis
Fry, T. J. (2001) · Blood · doi:10.1182/blood.v97.10.2983 · Cited by 405 · see citing works
Self-citationLymphopenia and interleukin-2 therapy alter homeostasis of CD4+CD25+ regulatory T cells
Zhang, H., Chua, K., Guimond, M., Kapoor, V., Brown, M., Fleisher, T. A., Long, L., Bernstein, D. B., Hill, B. J., Douek, D. C., et al. (2005) · Nature Medicine · doi:10.1038/nm1312 · Cited by 377 · see citing works
Self-citationThe main function of IL-2 is to promote the development of T regulatory cells
Malek, T. R. (2003) · Journal of Leukocyte Biology · doi:10.1189/jlb.0603272 · Cited by 330 · see citing works
Fry, T. J. (2002) · Blood · doi:10.1182/blood-2002-07-2297 · Cited by 234 · see citing works
Self-citationIn vivo expansion of CD4+CD45RO-CD25+ T cells expressing foxP3 in IL-2-treated HIV-infected patients
Sereti, I. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24307 · Cited by 122 · see citing works
Chu, Y., Memon, S. A., Sharrow, S. O., Hakim, F. T., Eckhaus, M., Lucas, P. J., & Gress, R. E. (2004) · Blood · doi:10.1182/blood-2003-10-3635 · Cited by 100 · see citing works
Self-citationMorrissey, P., Conlon, P. J., Braddy, S. C., et al. (1991) · The Journal of Immunology · doi:10.4049/jimmunol.146.5.1547 · Cited by 86 · see citing works
Development of lymphocytes in interleukin 7‐transgenic mice
Samaridis, J., Casorati, G., Traunecker, A., Iglesias, A. H., Gutierrez, J. C., Müller, U., & Palacios, R. (1991) · European Journal of Immunology · doi:10.1002/eji.1830210230 · Cited by 86 · see citing works
A dose effect of IL-7 on thymocyte development
Kassar, N. E., Lucas, P. J., Klug, D. B., Zamisch, M., Merchant, M. S., Bare, C. V., Choudhury, B., Sharrow, S. O., Richie, E. R., Mackall, C. L., et al. (2004) · Blood · doi:10.1182/blood-2004-01-0201 · Cited by 75 · see citing works
Self-citationFisher, A. G., Burdet, C., Bunce, C. M., et al. (1995) · International Immunology · doi:10.1093/intimm/7.3.415 · Cited by 70 · see citing works
Bakke, A. C., Purtzer, M. Z., & Wildin, R. S. (2004) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2004.02537.x · Cited by 33 · see citing works
Yeoman, H., Clark, D. R., & DeLuca, D. (1996) · Developmental & Comparative Immunology · doi:10.1016/0145-305x(96)00013-4 · Cited by 18 · see citing works
Talmadge, J. E., Jackson, J. D., Kelsey, L. S., et al. (1993) · Journal of Immunotherapy · doi:10.1097/00002371-199311000-00002 · Cited by 15 · see citing works
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Ahmadzadeh, M., Johnson, L. A., Heemskerk, B., Wunderlich, J. R., Dudley, M. E., White, D. E., & Rosenberg, S. A. (2009) · Blood · doi:10.1182/blood-2008-12-195792 · Cited by 1,766 · see citing works
Self-citationAiello, A., Farzaneh, F., Candore, G., Caruso, C., Davinelli, S., Gambino, C. M., Ligotti, M. E., Zareian, N., & Accardi, G. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02247 · Cited by 693 · see citing works
Thymic involution and immune reconstitution.
Lynch, H. E., Goldberg, G. L., Chidgey, A., Van den Brink, M. R. M., Boyd, R., & Sempowski, G. D. (2009) · Trends in Immunology · doi:10.1016/j.it.2009.04.003 · Cited by 522 · see citing works
Kinter, A. L., Godbout, E. J., McNally, J. P., Sereti, I., Roby, G. A., O’Shea, M. A., & Fauci, A. S. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.10.6738 · Cited by 513 · see citing works
Lévy, Y., Sereti, I., Tambussi, G., Routy, J. P., Lelièvre, J. D., Delfraissy, J. F., Molina, J. M., Fischl, M., Goujard, C., Rodriguez, B., et al. (2012) · Clinical Infectious Diseases · doi:10.1093/cid/cis383 · Cited by 240 · see citing works
Self-citationT cell regeneration after immunological injury
Velardi, E., Tsai, J. J., & van den Brink, M. R. M. (2021) · Nature Reviews Immunology · doi:10.1038/s41577-020-00457-z · Cited by 222 · see citing works
Aerobic fitness is associated with lower proportions of senescent blood T-cells in man
Spielmann, G., McFarlin, B. K., O’Connor, D. P., Smith, P. J. W., Pircher, H., & Simpson, R. J. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2011.07.226 · Cited by 180 · see citing works
Cytokine and Chemokine Signals of T‐Cell Exclusion in Tumors
Zhang, Y., Guan, X.-Y., & Jiang, P. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.594609 · Cited by 133 · see citing works
Mechanism of action of IL-7 and its potential applications and limitations in cancer immunotherapy
Gao, J., Zhao, L., Wan, Y., & Zhu, B. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms160510267 · Cited by 122 · see citing works
Shi, L. Z., Fu, T., Guan, B., Chen, J., Blando, J. M., Allison, J. P., Xiong, L., Subudhi, S. K., Gao, J., & Sharma, P. (2016) · Nature Communications · doi:10.1038/ncomms12335 · Cited by 111 · see citing works
Interleukin-7 and Immunosenescence
Nguyen, V., Mendelsohn, A., & Larrick, J. W. (2017) · Journal of Immunology Research · doi:10.1155/2017/4807853 · Cited by 96 · see citing works
Adoptive T-cell therapy for cancer: the era of engineered T cells
Bonini, C., & Mondino, A. (2015) · European Journal of Immunology · doi:10.1002/eji.201545552 · Cited by 93 · see citing works
Modulation of Signaling Mediated by TSLP and IL-7 in Inflammation, Autoimmune Diseases, and Cancer
Marković, I., & Savvides, S. N. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01557 · Cited by 86 · see citing works
Pongsachareonnont, P., Ying Kit Mak, M., Hurst, C., & Lam, W.-C. (2018) · Clinical Ophthalmology · doi:10.2147/opth.s171636 · Cited by 34 · see citing works
Cellular signalling pathways in immune aging and regeneration
Aspinall, R., Lapenna, A., B-Lynch, C., & Lang, P. O. (2014) · Biochemical Society Transactions · doi:10.1042/bst20140021 · Cited by 8 · see citing works
- Authors
- Rosenberg, S. A., Sportès, C., Ahmadzadeh, M., Fry, T. J., Ngo, L. T., Schwarz, S. L., Stetler-Stevenson, M., Morton, K. E., Mavroukakis, S. A., Morre, M., Buffet, R., Mackall, C. L., & Gress, R. E.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Rosenberg, Steven A.
- Ahmadzadeh, Mojgan
- Ngo, Lien T.
- Schwarz, Susan L.
- Morton, Kathleen E.
- Mavroukakis, Sharon A.
- ORCID
- Venue
- Journal of Immunotherapy
- Published
- 2006-05
- Volume
- 29
- Issue
- 3
- Pages
- 313-319
- ISSN
- 1524-9557 (ISSN-L)
- PMC
- PMC1473976
- OpenAlex
- W2004345869
- Cited by
- 443
- References
- 22
- Citations by year
- 2026: 5 · 2025: 17 · 2024: 17 · 2023: 20 · 2022: 14 · 2021: 17 · 2020: 20 · 2019: 18 · 2018: 19 · 2017: 17 · 2016: 17 · 2015: 17 · 2014: 19 · 2013: 22 · 2012: 31
- FWCI
- 12.87
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Immunotherapy (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (Z01SC003811)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- IL-7, recombinant cytokine therapy, lymphopenia, CD8+ T cells, CD4+ T cells, regulatory T cells, T cell expansion, HIV infection
- MeSH terms
- Adult, Aged, Bone Marrow, Bone Marrow Cells, Female, Humans, Male, Middle Aged, CD4-Positive T-Lymphocytes, Interleukin-7, CD8-Positive T-Lymphocytes, Lymphopoiesis, Cell Proliferation, T-Lymphocytes, Regulatory, Forkhead Transcription Factors
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