Cited by 443T-cell and B-cell ImmunologyHIV Research and TreatmentImmunotherapy and Immune Responses

IL-7 administration to humans leads to expansion of CD8+ and CD4+ cells but a relative decrease of CD4+ T-regulatory cells

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Rosenberg, Steven A., Sportès, Claude, Ahmadzadeh, Mojgan, Fry, Terry J., Ngo, Lien T., Schwarz, Susan L., Stetler-Stevenson, Maryalice, Morton, Kathleen E. +5 more·2006·Journal of Immunotherapy

Abstract

Lymphopenia is a serious consequence of HIV infection and the administration of cancer chemotherapeutic agents. Although growth factors can be administered to patients to increase circulating neutrophils, there is no effective method to stimulate CD8+ lymphocyte production in humans, in vivo. This report is the first to describe the administration of recombinant interleukin-7 to humans and demonstrates the ability of this cytokine to mediate selective increases in CD4+ and CD8+ lymphocytes along with a decrease in the percentage of CD4+ T-regulatory cells. These studies suggest an important role for interleukin-7 in the treatment of patients with lymphopenia.

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  • In the first clinical trial in humans, patients with metastatic cancer (age range 20-59 years) treated with different doses of IL-7 showed a dose-dependent increase in circulating CD4+ and CD8+ lymphocytes along with a decrease in Tregs.

    “In the first clinical trial in humans, patients with metastatic cancer (age range 20–59 years) treated with different doses of IL-7 showed a dose-dependent increase in circulating CD4+ and CD8+ lymphocytes along with a decrease in Tregs (162).”

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Authors
Rosenberg, S. A., Sportès, C., Ahmadzadeh, M., Fry, T. J., Ngo, L. T., Schwarz, S. L., Stetler-Stevenson, M., Morton, K. E., Mavroukakis, S. A., Morre, M., Buffet, R., Mackall, C. L., & Gress, R. E.
Affiliations
National Institutes of Health (US)
Corresponding author
  • Rosenberg, Steven A.
  • Ahmadzadeh, Mojgan
  • Ngo, Lien T.
  • Schwarz, Susan L.
  • Morton, Kathleen E.
  • Mavroukakis, Sharon A.
Venue
Journal of Immunotherapy
Published
2006-05
Volume
29
Issue
3
Pages
313-319
ISSN
1524-9557 (ISSN-L)
OpenAlex
W2004345869
Cited by
443
References
22
Citations by year
2026: 5 · 2025: 17 · 2024: 17 · 2023: 20 · 2022: 14 · 2021: 17 · 2020: 20 · 2019: 18 · 2018: 19 · 2017: 17 · 2016: 17 · 2015: 17 · 2014: 19 · 2013: 22 · 2012: 31
FWCI
12.87
Type
journal article
Language
en
Open access
Locations
  • Journal of Immunotherapy (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Cancer Institute (Z01SC003811)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Keywords
IL-7, recombinant cytokine therapy, lymphopenia, CD8+ T cells, CD4+ T cells, regulatory T cells, T cell expansion, HIV infection
MeSH terms
Adult, Aged, Bone Marrow, Bone Marrow Cells, Female, Humans, Male, Middle Aged, CD4-Positive T-Lymphocytes, Interleukin-7, CD8-Positive T-Lymphocytes, Lymphopoiesis, Cell Proliferation, T-Lymphocytes, Regulatory, Forkhead Transcription Factors

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