The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Vitamin K–containing dietary supplements: comparison of synthetic vitamin K1 and natto-derived menaquinone-7
Open accessAbstract
Vitamin K is a cofactor in the production of blood coagulation factors (in the liver), osteocalcin (in bone), and matrix Gla protein (cartilage and vessel wall). Accumulating evidence suggests that for optimal bone and vascular health, relatively high intakes of vitamin K are required. The synthetic short-chain vitamin K1 is commonly used in food supplements, but recently the natural long-chain menaquinone-7 (MK-7) has also become available as an over-the-counter (OTC) supplement. The purpose of this paper was to compare in healthy volunteers the absorption and efficacy of K1 and MK-7. Serum vitamin K species were used as a marker for absorption and osteocalcin carboxylation as a marker for activity. Both K1 and MK-7 were absorbed well, with peak serum concentrations at 4 hours after intake. A major difference between the 2 vitamin K species is the very long half-life time of MK-7, resulting in much more stable serum levels, and accumulation of MK-7 to higher levels (7- to 8-fold) during prolonged intake. MK-7 induced more complete carboxylation of osteocalcin, and hematologists should be aware that preparations supplying 50 μg/d or more of MK-7 may interfere with oral anticoagulant treatment in a clinically relevant way.
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Cites
Geleijnse, J. M., Vermeer, C., Grobbee, D. E., Schurgers, L. J., Knapen, M. H. J., van der Meer, I. M., Hofman, A., & Witteman, J. C. M. (2004) · The Journal of Nutrition · doi:10.1093/jn/134.11.3100 · Cited by 562
Self-citationSerum undercarboxylated osteocalcin is a marker of the risk of hip fracture in elderly women.
Szulc, P., Chapuy, M. C., Meunier, P. J., & Delmas, P. D. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116387 · Cited by 484
STAFFORD, D. W. (2005) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2005.01419.x · Cited by 402
Determination of Phylloquinone and Menaquinones in Food
Schurgers, L. J., & Vermeer, C. (2000) · Pathophysiology of Haemostasis and Thrombosis · doi:10.1159/000054147 · Cited by 397
Self-citationSerum undercarboxylated osteocalcin correlates with hip bone mineral density in elderly women
Szulc, P., Arlot, M., Chapuy, M.-C., Duboeuf, F., Meunier, P. J., & Dr. Delmas, P. D. (1994) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650091012 · Cited by 269
Kaneki, M., Hedges, S. J., Hosoi, T., Fujiwara, S., Lyons, A., Crean, S. J., Ishida, N., Nakagawa, M., Takechi, M., Sano, Y., et al. (2001) · Nutrition · doi:10.1016/s0899-9007(00)00554-2 · Cited by 248
Vitamin K1 Supplementation Retards Bone Loss in Postmenopausal Women Between 50 and 60 Years of Age
Braam, L. A. J. L. M., Knapen, M. H. J., Geusens, P., Brouns, F., Hamuly�k, K., Gerichhausen, M. J. W., & Vermeer, C. (2003) · Calcified Tissue International · doi:10.1007/s00223-002-2084-4 · Cited by 239
Self-citationDifferential lipoprotein transport pathways of K-vitamins in healthy subjects
Schurgers, L. J., & Vermeer, C. (2002) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(02)00147-2 · Cited by 234
Self-citationBraam, L., Hoeks, A., Brouns, F., Hamulyák, K., Gerichhausen, M., & Vermeer, C. (2004) · Thrombosis and Haemostasis · doi:10.1160/th03-07-0423 · Cited by 209
Self-citationLuukinen, H., Käkönen, S.-M., Pettersson, K., Koski, K., Laippala, P., Lövgren, T., Kivelä, S.-L., & Väänänen, H. K. (2000) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2000.15.12.2473 · Cited by 197
Cited by
Petsophonsakul, P., Furmanik, M., Forsythe, R., Dweck, M., Schurink, G. W., Natour, E., Reutelingsperger, C., Jacobs, M., Mees, B., & Schurgers, L. (2019) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.119.312787 · Cited by 341
Self-citationWestenfeld, R., Krueger, T., Schlieper, G., Cranenburg, E. C. M., Magdeleyns, E. J., Heidenreich, S., Holzmann, S., Vermeer, C., Jahnen-Dechent, W., Ketteler, M., et al. (2012) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2011.10.041 · Cited by 298
Self-citationWalther, B., Karl, J. P., Booth, S. L., & Boyaval, P. (2013) · Advances in Nutrition · doi:10.3945/an.113.003855 · Cited by 271
Roles for Vitamin K Beyond Coagulation
Booth, S. L. (2009) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-080508-141217 · Cited by 256
Halder, M., Petsophonsakul, P., Akbulut, A. C., Pavlic, A., Bohan, F., Anderson, E., Maresz, K., Kramann, R., & Schurgers, L. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20040896 · Cited by 256
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Metadata
- Authors
- Schurgers, L. J., Teunissen, K. J. F., Hamulyák, K., Knapen, M. H. J., Vik, H., & Vermeer, C.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2006-12-07
- Volume
- 109
- Issue
- 8
- Pages
- 3279-3283
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2144461421
- Cited by
- 423
- References
- 19
- FWCI
- 9.72
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Schurgers, L. J., Teunissen, K. J. F., Hamulyák, K., Knapen, M. H. J., Vik, H., & Vermeer, C. (2007). Vitamin K–containing dietary supplements: comparison of synthetic vitamin K1 and natto-derived menaquinone-7. Blood. https://doi.org/10.1182/blood-2006-08-040709
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