Determination of Phylloquinone and Menaquinones in Food
Abstract
Fluctuations in international normalized ratio values are often ascribed to dietary changes in vitamin K intake. Here we present a database with vitamin K(1) and K(2) contents of a wide variety of food items. K(1) was mainly present in green vegetables and plant margarins, K(2) in meat, liver, butter, egg yolk, natto, cheese and curd cheese. To investigate the effect of the food matrix on vitamin K bioavailability, 6 healthy male volunteers consumed either a detergent-solubilized K(1) (3.5 micromol) or a meal consisting 400 g of spinach (3.5 micromol K(1)) and 200 g of natto (3.1 micromol K(2)). The absorption of pure K(1) was faster than that of food-bound K vitamins (serum peak values at 4 h vs. 6 h after ingestion). Moreover, circulating K(2) concentrations after the consumption of natto were about 10 times higher than those of K(1) after eating spinach. It is concluded that the contribution of K(2) vitamins (menaquinones) to the human vitamin K status is presently underestimated, and that their potential interference with oral anticoagulant treatment needs to be investigated.
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Vitamin K might mitigate bone loss after intentional weight loss by inhibiting bone resorption and osteoclast formation.
“Vitamin K might have a role in mitigating bone loss following intentional weight loss by inhibiting bone resorption450 and osteoclast formation451.”
From Sarcopenic obesity in older adults: aetiology, epidemiology and treatment strategies (2018) · cites this paper as [451]
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Self-citationvan Gorp, R. H., & Schurgers, L. J. (2015) · Nutrients · doi:10.3390/nu7115479 · Cited by 88 · see citing works
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Determination of vitamin K composition of fermented food
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Role of K vitamins in the regulation of tissue calcification
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Self-citationMultiple Vitamin K Forms Exist in Dairy Foods
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US Pharmacopeial Convention safety evaluation of menaquinone-7, a form of vitamin K
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MK-7 and Its Effects on Bone Quality and Strength
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Intake of vitamin K1 and K2 and risk of hip fractures: The Hordaland Health Study
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Vitamin K2 Needs an RDI Separate from Vitamin K1
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Association Between Vitamin K and the Metabolic Syndrome: A 10-Year Follow-Up Study in Adults
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Self-citationThe Bone—Vasculature Axis: Calcium Supplementation and the Role of Vitamin K
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Self-citationEffects of vitamin K on calcium and bone metabolism
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Self-citationPronounced Elevation of Undercarboxylated Osteocalcin in Healthy Children
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Self-citation
- Authors
- Schurgers, L. J., & Vermeer, C.
- Affiliations
- Maastricht University (NL)
- Venue
- Pathophysiology of Haemostasis and Thrombosis
- Publisher
- S. Karger AG
- Published
- 2000
- Volume
- 30
- Issue
- 6
- Pages
- 298-307
- ISSN
- 1424-8832 (ISSN-L)
- 1424-8840
- OpenAlex
- W2032942340
- Cited by
- 397
- References
- 33
- Citations by year
- 2026: 12 · 2025: 12 · 2024: 17 · 2023: 18 · 2022: 23 · 2021: 37 · 2020: 28 · 2019: 24 · 2018: 21 · 2017: 18 · 2016: 18 · 2015: 20 · 2014: 16 · 2013: 20 · 2012: 24
- FWCI
- 3.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pathophysiology of Haemostasis and Thrombosis (publishedVersion)
- Research Publications (Maastricht University) (submittedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Vitamin K Research Studies
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Keywords
- vitamin K1, vitamin K2, vitamin K intake, food matrix, natto, spinach, oral anticoagulants, international normalized ratio
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