The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Deficient CD4+ CD25+ FOXP3+ T regulatory cells in acquired aplastic anemia
Open accessAbstract
Regulatory T cells are believed to control the development and progression of autoimmunity by suppressing autoreactive T cells. Decreased numbers of CD4(+)CD25(+) FOXP3(+) T cells (Tregs) are associated with impaired immune homeostasis and development of autoimmune diseases. The transcription factors FOXP3 and NFAT1 have key roles in regulatory T-cell development and function. We show that Tregs are decreased at presentation in almost all patients with aplastic anemia; FOXP3 protein and mRNA levels also are significantly lower in patients with aplastic anemia and NFAT1 protein levels are decreased or absent. Transfection of FOXP3-deficient CD4(+)CD25(+) T cells from patients with a plasmid encoding wild-type NFAT1 resulted in increased FOXP3 expression in these cells. By NFAT1 knockdown in CD4(+)CD25(+) T cells, FOXP3 expression was decreased when NFAT1 expression was decreased. Our findings indicate that decreased NFAT1 could explain low FOXP3 expression and diminished Treg frequency in aplastic anemia. Treg defects are now implicated in autoimmune marrow failure.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Another major effector of damage is a type 1 T-helper (Th1) cell-skewed response of the adaptive immune system, which was also identified as the major source of IFN-g, accompanied by a reduction in regulatory T cells (Tregs) in the marrow.60”
From Inflammatory bone marrow microenvironment (2019) · cites this paper as [60]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Sakaguchi, S. (2005) · Nature Immunology · doi:10.1038/ni1178 · Cited by 2,669
Loss of Functional Suppression by CD4+CD25+ Regulatory T Cells in Patients with Multiple Sclerosis
Viglietta, V., Baecher‐Allan, C., Weiner, H. L., & Hafler, D. A. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20031579 · Cited by 1,858
FOXP3 Controls Regulatory T Cell Function through Cooperation with NFAT
Wu, Y., Borde, M., Heissmeyer, V., Feuerer, M., Lapan, A. D., Stroud, J. C., Bates, D. L., Guo, L., Han, A., Ziegler, S. F., et al. (2006) · Cell · doi:10.1016/j.cell.2006.05.042 · Cited by 1,229
Current concepts in the pathophysiology and treatment of aplastic anemia
Young, N. S., Calado, R. T., & Scheinberg, P. (2006) · Blood · doi:10.1182/blood-2006-03-010777 · Cited by 888
Self-citationRegulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression
Wan, Y. Y., & Flavell, R. A. (2007) · Nature · doi:10.1038/nature05479 · Cited by 876
Toll-like receptor 2 controls expansion and function of regulatory T cells
Sutmuller, R. P. M. (2006) · Journal of Clinical Investigation · doi:10.1172/jci25439 · Cited by 750
Beyer, M., & Schultze, J. L. (2006) · Blood · doi:10.1182/blood-2006-02-002774 · Cited by 741
Multiple immuno-regulatory defects in type-1 diabetes
Kukreja, A., Cost, G., Marker, J., Zhang, C., Sun, Z., Lin‐Su, K., Ten, S., Sanz, M. M., Exley, M. A., Wilson, B., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci13605 · Cited by 640
The lifestyle of naturally occurring CD4+CD25+Foxp3+ regulatory T cells
Shevach, E. M., DiPaolo, R. J., Andersson, J., Zhao, D., Stephens, G. L., & Thornton, A. M. (2006) · Immunological Reviews · doi:10.1111/j.0105-2896.2006.00415.x · Cited by 589
Gambineri, E., Torgerson, T. R., & Ochs, H. D. (2003) · Current Opinion in Rheumatology · doi:10.1097/00002281-200307000-00010 · Cited by 575
Multiple immuno-regulatory defects in type-1 diabetes
Kukreja, A., Cost, G., Marker, J., Zhang, C., Sun, Z., Lin‐Su, K., Ten, S., Sanz, M. M., Exley, M. A., Wilson, B., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0213605 · Cited by 567
Global Natural Regulatory T Cell Depletion in Active Systemic Lupus Erythematosus
Miyara, M., Amoura, Z., Parizot, C., Badoual, C., Dorgham, K., Trad, S., Nochy, D., Debré, P., Pietté, J. C., & Gorochov, G. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.12.8392 · Cited by 468
Molecular Mechanisms Underlying FOXP3 Induction in Human T Cells
Mantel, P., Ouaked, N., Rückert, B., Karagiannidis, C., Welz, R., Blaser, K., & Schmidt‐Weber, C. B. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.6.3593 · Cited by 405
Rezvani, K., Mielke, S., Ahmadzadeh, M., Kilical, Y., Savani, B. N., Zeilah, J., Keyvanfar, K., Montero, A., Hensel, N. F., Kurlander, R. J., et al. (2006) · Blood · doi:10.1182/blood-2006-02-003996 · Cited by 368
Self-citationFunctional Study of CD4+CD25+ Regulatory T Cells in Health and Autoimmune Hepatitis
Longhi, M. S., Hussain, M. J., Mitry, R. R., Arora, S. K., Mieli‐Vergani, G., Vergani, D., & Ma, Y. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.7.4484 · Cited by 323
Beissert, S., Schwarz, A., & Schwarz, T. (2005) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700004 · Cited by 256
T-bet, a Th1 transcription factor, is up-regulated in T cells from patients with aplastic anemia
Solomou, E. E., Keyvanfar, K., & Young, N. S. (2006) · Blood · doi:10.1182/blood-2005-10-4201 · Cited by 148
Self-citationManzotti, C. N., Tipping, H., Perry, L., Mead, K. I., Blair, P. J., Zheng, Y., & Sansom, D. M. (2002) · European Journal of Immunology · doi:10.1002/1521-4141(2002010)32:10 · Cited by 142
FOXP3 and NFAT: Partners in Tolerance
Rudensky, A. Y., Gavin, M. A., & Zheng, Y. (2006) · Cell · doi:10.1016/j.cell.2006.07.005 · Cited by 110
Perforin gene mutations in patients with acquired aplastic anemia
Solomou, E. E., Gibellini, F., Stewart, B., Malide, D. A., Berg, M., Visconte, V., Green, S., Childs, R. W., Chanock, S. J., & Young, N. S. (2007) · Blood · doi:10.1182/blood-2006-12-063495 · Cited by 66
Self-citationSolomou, E. E., Juang, Y., & Tsokos, G. C. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.9.5665 · Cited by 58
Self-citationHerndon, T. M., Juang, Y., Solomou, E. E., Rothwell, S. W., Gourley, M. F., & Tsokos, G. C. (2002) · Clinical Immunology · doi:10.1006/clim.2002.5192 · Cited by 45
Self-citationAutoimmunity and Its Treatment in Aplastic Anemia
Young, N. S. (1997) · Annals of Internal Medicine · doi:10.7326/0003-4819-126-2-199701150-00014 · Cited by 30
Self-citationThe Medical Scientist and Medical Care
Stokes, J. (1970) · Archives of Internal Medicine · doi:10.1001/archinte.1970.00310070168016 · Cited by 2
Cited by
Sorted by citations
Young, N. S. (2018) · New England Journal of Medicine · doi:10.1056/nejmra1413485 · Cited by 762
Self-citationRejeski, K., Perez, A. P., Sesques, P., Hoster, E., Berger, C., Jentzsch, L., Mougiakakos, D., Frölich, L., Ackermann, J., Bücklein, V., et al. (2021) · Blood · doi:10.1182/blood.2020010543 · Cited by 501
How I treat acquired aplastic anemia
Scheinberg, P., & Young, N. S. (2012) · Blood · doi:10.1182/blood-2011-12-274019 · Cited by 446
Self-citationDesmond, R. G., Townsley, D. M., Dumitriu, B., Olnes, M. J., Scheinberg, P., Bevans, M. F., Parikh, A. R., Broder, K., Calvo, K. R., Wu, C. O., et al. (2013) · Blood · doi:10.1182/blood-2013-10-534743 · Cited by 401
Self-citationFeng, X., Kajigaya, S., Solomou, E. E., Keyvanfar, K., Xu, X., Raghavachari, N., Munson, P. J., Herndon, T. M., Chen, J., & Young, N. S. (2008) · Blood · doi:10.1182/blood-2008-01-130146 · Cited by 239
Self-citation
Metadata
- Authors
- Solomou, E. E., Rezvani, K., Mielke, S., Malide, D., Keyvanfar, K., Visconte, V., Kajigaya, S., Barrett, A. J., & Young, N. S.
- Affiliations
- Hematology Branch and
- National Institutes of Health (US)
- ORCID
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2007-09-01
- Volume
- 110
- Issue
- 5
- Pages
- 1603-1606
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- PMC
- PMC1975843
- OpenAlex
- W2066935327
- Cited by
- 225
- References
- 24
- Citations by year
- 2026: 11 · 2025: 8 · 2024: 10 · 2023: 11 · 2022: 7 · 2021: 11 · 2020: 21 · 2019: 10 · 2018: 18 · 2017: 19 · 2016: 9 · 2015: 11 · 2014: 11 · 2013: 10 · 2012: 11
- FWCI
- 4.59
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Blood (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Hematology › Blood disorders and treatments
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Keywords
- regulatory T cells, CD4+CD25+ T cells, Foxp3, NFAT1, acquired aplastic anemia, Treg deficiency, immune homeostasis, transcription factors, Treg reprogramming
- MeSH terms
- Adolescent, Adult, Anemia, Aplastic, Autoimmune Diseases, Cells, Cultured, Female, Gene Expression Regulation, Humans, Male, Middle Aged, Transfection, Autoimmunity, T-Lymphocytes, Regulatory, NFATC Transcription Factors, Forkhead Transcription Factors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
