The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
High-resolution donor-recipient HLA matching contributes to the success of unrelated donor marrow transplantation
Open accessAbstract
The relative importance of various human leukocyte antigen (HLA) loci and the resolution level at which they are matched has not been fully defined for unrelated donor transplantation. To address this question, National Marrow Donor Program data from 3857 transplantations performed from 1988 to 2003 in the United States were analyzed. Patient-donor pairs were fully typed for HLA-A, -B, -C, -DRB1, -DQB1, -DQA1, -DPB1, and -DPA1 alleles. High-resolution DNA matching for HLA-A, -B, -C, and -DRB1 (8/8 match) was the minimum level of matching associated with the highest survival. A single mismatch detected by low- or high-resolution DNA testing at HLA-A, -B, -C or -DRB1 (7/8 match) was associated with higher mortality (relative risk, 1.25; 95% CI, 1.13-1.38; P < .001) and 1-year survival of 43% compared with 52% for 8/8 matched pairs. Single mismatches at HLA-B or HLA-C appear better tolerated than mismatches at HLA-A or HLA-DRB1. Mismatching at 2 or more loci compounded the risk. Mismatching at HLA-DP or -DQ loci and donor factors other than HLA type were not associated with survival. In multivariate modeling, patient age, race, disease stage, and cytomegalovirus status were as predictive of survival as donor HLA matching. High-resolution DNA matching for HLA-A, -B, -C, and -DRB1 alleles is associated with higher rates of survival.
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Chronic graft-versus-host syndrome in man
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Limits of HLA mismatching in unrelated hematopoietic cell transplantation
Petersdorf, E. W., Anasetti, C., Martin, P. J., Gooley, T., Radich, J., Malkki, M., Woolfrey, A., Smith, A., Mickelson, E., & Hansen, J. A. (2004) · Blood · doi:10.1182/blood-2004-04-1674 · Cited by 263
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Cited by
Kollman, C., Spellman, S. R., Zhang, M.-J., Hassebroek, A., Anasetti, C., Antin, J. H., Champlin, R. E., Confer, D. L., DiPersio, J. F., Fernandez-Viña, M., et al. (2016) · Blood · doi:10.1182/blood-2015-08-663823 · Cited by 365
Self-citationFleischhauer, K., Shaw, B. E., Gooley, T., Malkki, M., Bardy, P., Bignon, J.-D., Dubois, V., Horowitz, M. M., Madrigal, J. A., Morishima, Y., et al. (2012) · The Lancet Oncology · doi:10.1016/s1470-2045(12)70004-9 · Cited by 357
Self-citationHigh HLA-DP Expression and Graft-versus-Host Disease
Petersdorf, E. W., Malkki, M., O’hUigin, C., Carrington, M., Gooley, T., Haagenson, M. D., Horowitz, M. M., Spellman, S. R., Wang, T., & Stevenson, P. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1500140 · Cited by 278
Self-citationLee, S., Huh, J. Y., Turner, D. M., Lee, S., Robinson, J., Stein, J. E., Shim, S. H., Hong, C. P., Kang, M. S., Nakagawa, M., et al. (2018) · Stem Cells · doi:10.1002/stem.2865 · Cited by 99
Routy, B., Letendre, C., Enot, D., Chénard-Poirier, M., Mehraj, V., Séguin, N. C., Guenda, K., Gagnon, K., Woerther, P.-L., Ghez, D., et al. (2017) · OncoImmunology · doi:10.1080/2162402x.2016.1258506 · Cited by 75
Metadata
- Authors
- Lee, S. J., Klein, J., Haagenson, M., Baxter-Lowe, L. A., Confer, D. L., Eapen, M., Fernandez-Vina, M., Flomenberg, N., Horowitz, M., Hurley, C. K., Noreen, H., Oudshoorn, M., Petersdorf, E., Setterholm, M., Spellman, S., Weisdorf, D., Williams, T. M., & Anasetti, C.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2007-12-15
- Volume
- 110
- Issue
- 13
- Pages
- 4576-4583
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2061069485
- Cited by
- 1,255
- References
- 15
- FWCI
- 35.56
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Lee, S. J., Klein, J., Haagenson, M., Baxter-Lowe, L. A., Confer, D. L., Eapen, M., Fernandez-Vina, M., Flomenberg, N., Horowitz, M., Hurley, C. K., Noreen, H., Oudshoorn, M., Petersdorf, E., Setterholm, M., Spellman, S., Weisdorf, D., Williams, T. M., & Anasetti, C. (2007). High-resolution donor-recipient HLA matching contributes to the success of unrelated donor marrow transplantation. Blood. https://doi.org/10.1182/blood-2007-06-097386
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
