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All primitive and definitive hematopoietic progenitor cells emerging before E10 in the mouse embryo are products of the yolk sac
Open accessAbstract
The relative contribution of yolk sac (YS)–derived cells to the circulating definitive hematopoietic progenitor cell (HPC) pool that seeds the fetal liver remains controversial due to the presence of systemic circulation and the onset of hematopoiesis within the embryo proper (EP) before liver seeding. Ncx1−/− embryos fail to initiate a heartbeat on embryonic day (E) 8.25, but continue to develop through E10. We detected normal numbers of primitive erythroid progenitors in Ncx1−/− versus wild type (WT) YS, but primitive erythroblasts did not circulate in the Ncx1−/− EP. While there was no significant difference in the number of definitive HPCs in Ncx1−/− versus WT YS through E9.5, the Ncx1−/− EP was nearly devoid of HPCs. Thus, primitive erythroblasts and essentially all definitive HPCs destined to initially seed the fetal liver after E9.5 are generated in the YS between E7.0-E9.5 and are redistributed into the EP via the systemic circulation.
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Citations
Cited by
Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors
Gomez Perdiguero, E., Klapproth, K., Schulz, C., Busch, K., Azzoni, E., Crozet, L., Garner, H., Trouillet, C., de Bruijn, M. F., Geissmann, F., et al. (2015) · Nature · doi:10.1038/nature13989 · Cited by 2,339
Of lineage and legacy: the development of mammalian hematopoietic stem cells
Dzierzak, E., & Speck, N. A. (2008) · Nature Immunology · doi:10.1038/ni1560 · Cited by 707
McGrath, K. E., Frame, J. M., Fegan, K. H., Bowen, J. R., Conway, S. J., Catherman, S. C., Kingsley, P. D., Koniski, A. D., & Palis, J. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.05.036 · Cited by 433
Self-citationMoignard, V., Woodhouse, S., Haghverdi, L., Lilly, A. J., Tanaka, Y., Wilkinson, A. C., Buettner, F., Macaulay, I. C., Jawaid, W., Diamanti, E., et al. (2015) · Nature Biotechnology · doi:10.1038/nbt.3154 · Cited by 380
Yolk sac macrophage progenitors traffic to the embryo during defined stages of development
Stremmel, C., Schuchert, R., Wagner, F., Thaler, R., Weinberger, T., Pick, R., Mass, E., Ishikawa-Ankerhold, H. C., Margraf, A., Hutter, S., et al. (2018) · Nature Communications · doi:10.1038/s41467-017-02492-2 · Cited by 278
Metadata
- Authors
- Lux, C. T., Yoshimoto, M., McGrath, K., Conway, S. J., Palis, J., & Yoder, M. C.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2008-04-01
- Volume
- 111
- Issue
- 7
- Pages
- 3435-3438
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2082414007
- Cited by
- 273
- References
- 0
- FWCI
- 11.92
- Type
- journal article
- Language
- en
- Open access
- green
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- Lux, C. T., Yoshimoto, M., McGrath, K., Conway, S. J., Palis, J., & Yoder, M. C. (2008). All primitive and definitive hematopoietic progenitor cells emerging before E10 in the mouse embryo are products of the yolk sac. Blood. https://doi.org/10.1182/blood-2007-08-107086
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