The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Human CD25highFoxp3pos regulatory T cells differentiate into IL-17–producing cells
Open accessAbstract
The effector T-cell lineage shows great plasticity. Th17 cells are acknowledged to be instrumental in the response against microbial infection, but are also associated with autoimmune inflammatory processes. Here, we report that human regulatory T cells (CD4posCD25highFoxp3posCD127negCD27pos) can differentiate into IL-17–producing cells, when stimulated by allogeneic antigen-presenting cells, especially monocytes, in the presence of rhIL-2/rhIL-15. These regulatory T cell (Treg)–derived IL-17–producing cells showed high expression of the Th17-related transcription factor RORγt and were positively identified by CCR6 expression. This differentiation process was enhanced by exogenous IL-1β, IL-23, and IL-21, whereas IL-6 or TGFβ did not affect the emergence of IL-17–producing cells. The addition of IL-1 receptor antagonist (IL-1Ra), but not anti–IL-23 antibody, reduced IL-17–producing cell numbers. When an histone deacetylase (HDAC) inhibitor trichostatin A (TSA) was evaluated, we found a profound negative effect on the emergence of IL-17–producing cells from Tregs, implying that Treg differentiation into IL-17–producing cells depends on histone/protein deacetylase activity. Thus, the data suggest that epigenetic modification underlies the phenomenon of Treg plasticity here described.
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A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
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Transforming growth factor-β induces development of the TH17 lineage
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Central Memory and Effector Memory T Cell Subsets: Function, Generation, and Maintenance
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CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells
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Phenotypic and functional features of human Th17 cells
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Cited by
Plasticity of CD4+ T Cell Lineage Differentiation
Zhou, L., Chong, M. M. W., & Littman, D. R. (2009) · Immunity · doi:10.1016/j.immuni.2009.05.001 · Cited by 1,551
Regulatory T cells in autoimmune disease
Dominguez-Villar, M., & Hafler, D. A. (2018) · Nature Immunology · doi:10.1038/s41590-018-0120-4 · Cited by 713
Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage?
Huehn, J., Polansky, J. K., & Hamann, A. (2009) · Nature Reviews Immunology · doi:10.1038/nri2474 · Cited by 526
Past, Present, and Future of Regulatory T Cell Therapy in Transplantation and Autoimmunity
Romano, M., Fanelli, G., Albany, C. J., Giganti, G., & Lombardi, G. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00043 · Cited by 512
Harnessing the plasticity of CD4+ T cells to treat immune-mediated disease
DuPage, M., & Bluestone, J. A. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2015.18 · Cited by 513
Metadata
- Authors
- Koenen, H. J. P. M., Smeets, R. L., Vink, P. M., van Rijssen, E., Boots, A. M. H., & Joosten, I.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2008-09-15
- Volume
- 112
- Issue
- 6
- Pages
- 2340-2352
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2042586707
- Cited by
- 736
- References
- 19
- FWCI
- 25.68
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Koenen, H. J. P. M., Smeets, R. L., Vink, P. M., van Rijssen, E., Boots, A. M. H., & Joosten, I. (2008). Human CD25highFoxp3pos regulatory T cells differentiate into IL-17–producing cells. Blood. https://doi.org/10.1182/blood-2008-01-133967
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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