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Cited by 713T-cell and B-cell ImmunologyPsoriasis: Treatment and PathogenesisReproductive System and Pregnancy

Regulatory T cells in autoimmune disease

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Dominguez-Villar, Margarita, Hafler, David A.·2018·Nature Immunology
DOI 10.1038/s41590-018-0120-4PMC PMC7882196
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Abstract

In recent years, the understanding of regulatory T cell (T reg cell) biology has expanded considerably. Key observations have challenged the traditional definition of T reg cells and have provided insight into the underlying mechanisms responsible for the development of autoimmune diseases, with new therapeutic strategies that improve disease outcome. This Review summarizes the newer concepts of T reg cell instability, T reg cell plasticity and tissue-specific T reg cells, and their relationship to autoimmunity. Those three main concepts have changed the understanding of T reg cell biology: how they interact with other immune and non-immune cells; their functions in specific tissues; and the implications of this for the pathogenesis of autoimmune diseases.

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Authors
Dominguez-Villar, M., & Hafler, D. A.
Affiliations
Yale University (US)
Corresponding author
Hafler, David A.
ORCID
Hafler, David A.
Venue
Nature Immunology
Publisher
Springer Science and Business Media LLC
Published
2018-06-20
Volume
19
Issue
7
Pages
665-673
ISSN
  • 1529-2908 (ISSN-L)
  • 1529-2916
DOI
10.1038/s41590-018-0120-4
PMC
PMC7882196
OpenAlex
W2808296583
Cited by
713
References
11
Citations by year
2026: 56 · 2025: 70 · 2024: 105 · 2023: 108 · 2022: 99 · 2021: 105 · 2020: 88 · 2019: 70 · 2018: 9 · 2014: 1 · 2013: 1
FWCI
6.97
Type
journal article
Language
en
Open access
Licence
www.springer.com/tdm (tdm)
Locations
  • Nature Immunology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Allergy and Infectious Diseases (P01AI073748)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
  • Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
Keywords
regulatory T cells, autoimmune disease, peripheral tolerance, autoimmune disease pathogenesis, Treg therapy
MeSH terms
Animals, Autoimmune Diseases, Humans, T-Lymphocytes, Regulatory, Mice, Forkhead Transcription Factors

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