Adenosine receptors in regulation of dendritic cell differentiation and function

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Arginase-Producing Myeloid Suppressor Cells in Renal Cell Carcinoma Patients: A Mechanism of Tumor Evasion

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Purinergic signalling links mechanical breath profile and alveolar mechanics with the pro-inflammatory innate immune response causing ventilation-induced lung injury

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Immune Cell Metabolism in Tumor Microenvironment

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Role of dendritic cell metabolic reprogramming in tumor immune evasion

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Adenosine Signaling in the Tumor Microenvironment

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Dendritic cell-based cancer immunotherapy in the era of immune checkpoint inhibitors: From bench to bedside

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Improving combination therapies: targeting A2B-adenosine receptor to modulate metabolic tumor microenvironment and immunosuppression

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A2B adenosine receptor activation switches differentiation of bone marrow cells to a CD11c+Gr‐1+ dendritic cell subset that promotes the Th17 response

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Dendritic Cells in Cancer

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CD73; a key ectonucleotidase in the development of breast cancer: Recent advances and perspectives

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PD-L1/PD-1 Axis in Multiple Myeloma Microenvironment and a Possible Link with CD38-Mediated Immune-Suppression

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Circulating mycobacterial-reactive CD4+ T cells with an immunosuppressive phenotype are higher in active tuberculosis than latent tuberculosis infection

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Therapeutic Potentials of A2B Adenosine Receptor Ligands: Current Status and Perspectives

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Augmenting the therapeutic efficacy of adenosine against pancreatic cancer by switching the Akt/p21-dependent senescence to apoptosis

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Regulation of tumor infiltrated innate immune cells by adenosine

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IFN-γ and CD38 in Hyperprogressive Cancer Development

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Tumor intrinsic and extrinsic functions of CD73 and the adenosine pathway in lung cancer

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The resurgence of the Adora2b receptor as an immunotherapeutic target in pancreatic cancer

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Dual A2A/A2B Adenosine Receptor Antagonist M1069 Counteracts Immunosuppressive Mechanisms of Adenosine and Reduces Tumor Growth In Vivo

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Antiangiogenic therapy improves the antitumor effect of adoptive cell immunotherapy by normalizing tumor vasculature

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Nucleosides from Phlebotomus papatasi Salivary Gland Ameliorate Murine Collagen-Induced Arthritis by Impairing Dendritic Cell Functions

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The Adenosine System at the Crossroads of Intestinal Inflammation and Neoplasia

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The immunomodulatory function of adenosine in sepsis

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Unlocking antitumor immunity with adenosine receptor blockers

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Metabolic Signaling in the Tumor Microenvironment

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Adenosine, bridging chronic inflammation and tumor growth

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Targeting ENPP1 for cancer immunotherapy: Killing two birds with one stone

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Implantable Biomaterials for Cancer Immunotherapies

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Immunometabolism: A ‘Hot’ Switch for ‘Cold’ Pediatric Solid Tumors

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Spatial transcriptome and single-cell reveal the role of nucleotide metabolism in colorectal cancer progression and tumor microenvironment

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Dendritic cells: understanding ontogeny, subsets, functions, and their clinical applications

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Interplay of Immunometabolism and Epithelial–Mesenchymal Transition in the Tumor Microenvironment

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Adenosine in the Inflamed Gut: A Janus Faced Compound

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Dendritic Cell Subsets in Melanoma: Pathophysiology, Clinical Prognosis and Therapeutic Exploitation

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Attenuated transforming growth factor beta signaling promotes metastasis in a model of HER2 mammary carcinogenesis

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Novel combinatorial strategies for boosting the efficacy of immune checkpoint inhibitors in advanced breast cancers

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Role of adenosine A2B receptor signaling in contribution of cardiac mesenchymal stem-like cells to myocardial scar formation

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Nucleosides Present on Phlebotomine Saliva Induce Immunossuppression and Promote the Infection Establishment

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Adenosine/TGFβ axis in regulation of mammary fibroblast functions

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Current Adenosinergic Therapies: What Do Cancer Cells Stand to Gain and Lose?

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CD73 contributes to anti‐inflammatory properties of afferent lymphatic endothelial cells in humans and mice

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Discovery of potent and selective bicyclic A2B adenosine receptor antagonists via bioisosteric amide replacement

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Monitoring of the Immune Dysfunction in Cancer Patients

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Hypoperfusion is a potential inducer of immunosuppressive network in Alzheimer's disease

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Consideration of possible effects of vitamin D on established cancer, with reference to malignant melanoma

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The role of adenosine A1 receptor on immune cells

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Mechanisms of tumor-induced T cell immune suppression and therapeutics to counter those effects

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Pediatric tolerogenic DCs expressing CD4 and immunoglobulin‐like transcript receptor (ILT)‐4 secrete IL‐10 in response to Fc and adenosine

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Cyclic Nucleotides and Phosphodiesterases in Monocytic Differentiation

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Metabolic Interplay between the Immune System and Melanoma Cells: Therapeutic Implications

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Discovery of N-(5,6-diarylpyridin-2-yl)amide derivatives as potent and selective A2B adenosine receptor antagonists

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Extracellular vesicles from obese visceral adipose promote pancreatic cancer development and resistance to immune checkpoint blockade therapy

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Effect of DPP4/CD26 expression on SARS‑CoV‑2 susceptibility, immune response, adenosine (derivatives m62A and CD) regulations on patients with cancer and healthy individuals

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Immunosurveillance of cancer cell stress

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Immunoregulatory signal networks and tumor immune evasion mechanisms: insights into therapeutic targets and agents in clinical development

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The role of dendritic cells in radiation-induced immune responses

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Role of adenosine in tumor progression: focus on A2B receptor as potential therapeutic target

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Vascular Adenosine Receptors; Potential Clinical Applications

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Increased degradation of ATP is driven by memory regulatory T cells in kidney transplantation tolerance

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Combined inhibition of EZH2 and CD73 molecules by folic acid-conjugated SPION-TMC nanocarriers loaded with siRNA molecules prevents TNBC progression and restores anti-tumor responses

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Landscape of adenosine pathway and immune checkpoint dual blockade in NSCLC: progress in basic research and clinical application

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Targeted therapy of pyrrolo[2,3-d]pyrimidine antifolates in a syngeneic mouse model of high grade serous ovarian cancer and the impact on the tumor microenvironment

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CDK2 and CDK4 play important roles in promoting the proliferation of SKOV3 ovarian carcinoma cells induced by tumor-associated macrophages

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Targeting of G-protein coupled receptors in sepsis

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Expression of adenosine receptors in monocytes from patients with bronchial asthma

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Glioma progression in diabesity

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Adenosine A2A receptor, a potential valuable target for controlling reoxygenated DCs-triggered inflammation

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Purine metabolism-related gene expression signature predicts survival outcome and indicates immune microenvironment profile of gliomas

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The immunogenic radiation and new players in immunotherapy and targeted therapy for head and neck cancer

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Requirement of NK Cells for Selective A 2A Receptor Blockade to Suppress CD73 + Tumor Metastasis

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Metabolites: deciphering the molecular language between DCs and their environment

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CD73 expression is critical to therapeutic effects of human endometrial regenerative cells in inhibition of cardiac allograft rejection in mice

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Insights from Clinical Trials on A 2A Adenosine Receptor Antagonists for Cancer Treatment

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Cholera Toxin Impairs the Differentiation of Monocytes into Dendritic Cells, Inducing Professional Antigen-Presenting Myeloid Cells

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AMP Affects Intracellular Ca2+ Signaling, Migration, Cytokine Secretion and T Cell Priming Capacity of Dendritic Cells

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Adenosine Regulation of the Immune System

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Characteristics and the role of purinergic receptors in pathophysiology with focus on immune response

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The adenosinergic machinery in cancer: In-tandem insights from basic mechanisms to therapy

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Progress of dendritic cell-based cancer vaccines for patients with hematological malignancies

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Next-Generation Dendritic Cell-Based Vaccines for Leukemia Patients

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Targeting the adenosinergic axis in cancer immunotherapy: Insights into A2A and A2B receptors and novel clinical combination strategies

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The Potential Role of Exosomal Proteins in Prostate Cancer

Feng, S., Lou, K., Zou, X., Zou, J., & Zhang, G. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.873296 · Cited by 12

Metabolic reprogramming by adenosine antagonism and implications in non-small cell lung cancer therapy

Guan, S., Suman, S., Amann, J. M., Wu, R., Carbone, D. P., Wang, J., & Dikov, M. M. (2022) · Neoplasia · doi:10.1016/j.neo.2022.100824 · Cited by 13

Manipulation of indoleamine 2,3-dioxygenase (IDO) for clinical transplantation: promises and challenges

Quan, J., Tan, P., MacDonald, A., & Friend, P. J. (2008) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.8.11.1705 · Cited by 13

A2AR eGFP reporter mouse enables elucidation of A2AR expression dynamics during anti-tumor immune responses

Todd, K. L., Lai, J., Sek, K., Huang, Y., Newman, D. M., Derrick, E. B., Koay, H., Nguyen, D. Q., Hoang, T. X., Petley, E. V., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-42734-0 · Cited by 13

Human Blood Plasma Shapes Distinct Neonatal TLR-Mediated Dendritic Cell Activation via Expression of the MicroRNA Let-7g

England, R. N., Pak, J., Liu, M., Rao, S., Ozonoff, A., Levy, O., & van Haren, S. D. (2021) · ImmunoHorizons · doi:10.4049/immunohorizons.2000081 · Cited by 11

Evaluation of autophagy mediators in myeloid-derived suppressor cells during human tuberculosis

Kotzé, L. A., Leukes, V., Fang, Z., Lutz, M. B., Fitzgerald, B. L., Belisle, J. T., Loxton, A. G., Walzl, G., & du Plessis, N. (2021) · Cellular Immunology · doi:10.1016/j.cellimm.2021.104426 · Cited by 11

Novel classes of immunotherapy for breast cancer

Hernando‐Calvo, A., Cescon, D. W., & Bedard, P. L. (2021) · Breast Cancer Research and Treatment · doi:10.1007/s10549-021-06405-2 · Cited by 11

Colorectal cancer peritoneal metastasis is promoted by tissue-specific fibroblasts that can arise in response to various local disorders

Ramos, C., Walterskirchen, N., Knöbl, V., Zotter, C., Müller, C., Gerakopoulos, V., Rauch, A. E., Falk, L., Sachet, M., D’Angelo, E., et al. (2025) · Cancer Letters · doi:10.1016/j.canlet.2025.217686 · Cited by 12

Reducing Lung ATP Levels and Alleviating Asthmatic Airway Inflammation through Adeno-Associated Viral Vector-Mediated CD39 Expression

Huang, Y.-A., Chen, J., Wu, C., Hsu, C., Ko, A. M., Chen, L., & Kuo, M. (2021) · Biomedicines · doi:10.3390/biomedicines9060656 · Cited by 10

A2BAR expression in non-immune cells plays an important role in the development of murine colitis

Ingersoll, S. A., Laroui, H., Kolachala, V. L., Wang, L., Garg, P., Denning, T. L., Gewirtz, A. T., Merlin, D., & Sitaraman, S. V. (2012) · Digestive and Liver Disease · doi:10.1016/j.dld.2012.05.013 · Cited by 10

Induction of pathogenic cytotoxic T lymphocyte tolerance by dendritic cells: a novel therapeutic target

Gill, D., & Tan, P. (2010) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2010.499360 · Cited by 9

CD73+ Dendritic Cells in Cascading Th17 Responses of Experimental Autoimmune Uveitis-Induced Mice

Ko, M. K., Shao, H., Kaplan, H. J., & Sun, D. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.601272 · Cited by 11

Damage-associated molecular pattern (DAMP) activation in melanoma: investigation of the immunogenic activity of 15-deoxy, Δ12,14 prostamide J2

Elhassanny, A. E. M., Escobedo, R., Ladin, D. A., Burns, C., & Dross, R. V. (2020) · Oncotarget · doi:10.18632/oncotarget.27856 · Cited by 10

Immunosuppressive adenosine-targeted biomaterials for emerging cancer immunotherapy

Wei, Q., Zhang, L., Zhao, N., Cheng, Z., Hua, X., & Ding, J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1012927 · Cited by 10

PET Imaging of Adenosine Receptors in Diseases

Li, J., Hong, X., Li, G., Conti, P. S., Zhang, X., & Chen, K. (2019) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026619666190708163407 · Cited by 10

From the Inside Out: Exposing the Roles of Urea Cycle Enzymes in Tumors and Their Micro and Macro EnvironmentsPreprint

Hajaj, E., Pozzi, S., & Erez, A. (2023) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a041538 · Cited by 10

Development of a Scalable and Practical Synthesis of AB928, a Dual A2a/A2b Receptor Antagonist

Sharif, E. U., Miles, D. H., Rosen, B. R., Jeffrey, J. L., Debien, L., Powers, J. P., & Leleti, M. R. (2020) · Organic Process Research & Development · doi:10.1021/acs.oprd.0c00124 · Cited by 9

Preclinical Safety Evaluation of ASCs Engineered by FLPo/Frt-Based Hybrid Baculovirus: In Vitro and Large Animal Studies

Li, K., Chang, Y., Lin, C., Hwang, S., Wang, T., & Hu, Y. (2015) · Tissue Engineering Part A · doi:10.1089/ten.tea.2014.0465 · Cited by 9

Effect of Octreotide Long-Acting Release on Tregs and MDSC Cells in Neuroendocrine Tumour Patients: A Pivotal Prospective Study

von Arx, C., Rea, G., Napolitano, M., Ottaiano, A., Tatangelo, F., Izzo, F., Petrillo, A., Clemente, O., Sarno, A. D., Botti, G., et al. (2020) · Cancers · doi:10.3390/cancers12092422 · Cited by 9

IMMUNOBIOLOGY Adenosine receptors in regulation of dendritic cell differentiation and function

Novitskiy, S. V., Ryzhov, S., Zaynagetdinov, R., Goldstein, A. E., Huang, Y., Tikhomirov, O. Y., Blackburn, M. R., Biaggioni, I., Carbone, D. P., Feoktistov, I., et al. (2016)

Adenosine A 2B receptors in regulation of dendritic cell differentiation and function

Ryzhov, S. V., Novitskiy, S. V., Zaynagetdinov, R., Goldstein, A. E., Biaggioni, I., Carbone, D. P., Feoktistov, I., & Dikov, M. M. (2008) · The FASEB Journal · doi:10.1096/fasebj.22.1_supplement.1065.34 · Cited by 2

The A2B Adenosine Receptor Promotes Th17 Differentiation via Stimulation of Dendritic Cell IL-6

Wilson, J. M., Kurtz, C. C., Black, S. G., Ross, W. G., Alam, M. S., Linden, J. M., & Ernst, P. B. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100117 · Cited by 97

Adenosine and cAMP signalling skew human dendritic cell differentiation towards a tolerogenic phenotype with defective CD8+ T‐cell priming capacity

Challier, J., Bruniquel, D., Sewell, A. K., & Laugel, B. (2012) · Immunology · doi:10.1111/imm.12053 · Cited by 81

Adenosine affects expression of membrane molecules, cytokine and chemokine release, and the T-cell stimulatory capacity of human dendritic cells

Panther, E., Corinti, S., Idzko, M., Herouy, Y., Napp, M., la Sala, A., Girolomoni, G., & Norgauer, J. (2003) · Blood · doi:10.1182/blood-2002-07-2113 · Cited by 229