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MT1-MMP collagenolytic activity is regulated through association with tetraspanin CD151 in primary endothelial cells.

Yañez-Mó, María, Barreiro, Olga, Gonzalo, Pilar, Batista, Alicia, Megías, Diego, Genís, Laura, Sachs, Norman, Sala-Valdés, Mónica, Alonso, Miguel A., Montoya, María C., Sonnenberg, Arnoud, Arroyo, Alicia G., Sánchez-Madrid, Francisco·2008·Blood
DOI 10.1182/blood-2008-02-139394
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Abstract

MT1-MMP plays a key role in endothelial function, as underscored by the angiogenic defects found in MT1-MMP deficient mice. We have studied the molecular interactions that underlie the functional regulation of MT1-MMP. At lateral endothelial cell junctions, MT1-MMP colocalizes with tetraspanin CD151 (Tspan 24) and its associated partner α3β1 integrin. Biochemical and FRET analyses show that MT1-MMP, through its hemopexin domain, associates tightly with CD151, thus forming α3β1 integrin/CD151/MT1-MMP ternary complexes. siRNA knockdown of HUVEC CD151 expression enhanced MT1-MMP-mediated activation of MMP2, and the same activation was seen in ex vivo lung endothelial cells isolated from CD151-deficient mice. However, analysis of collagen degradation in these experimental models revealed a diminished MT1-MMP enzymatic activity in confined areas around the cell periphery. CD151 knockdown affected both MT1-MMP subcellular localization and its inclusion into detergent-resistant membrane domains, and prevented biochemical association of the metalloproteinase with the integrin α3β1. These data provide evidence for a novel regulatory role of tetraspanin microdomains on the collagenolytic activity of MT1-MMP and indicate that CD151 is a key regulator of MT1-MMP in endothelial homeostasis.

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Research works printed but not linked: 41

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Metadata

Authors
Yañez-Mó, M., Barreiro, O., Gonzalo, P., Batista, A., Megías, D., Genís, L., Sachs, N., Sala-Valdés, M., Alonso, M. A., Montoya, M. C., Sonnenberg, A., Arroyo, A. G., & Sánchez-Madrid, F.
Affiliations
  • Servicio de Inmunología, Hospital de la Princesa, Universidad Autónoma de Madrid, Madrid, Spain;
  • Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain;
  • Centro de Biología Molecular Severo Ochoa, Universidad Autónoma de Madrid, Consejo Superior de Investigaciones Científicas, Madrid, Spain;
  • Centro Nacional de Investigaciones Oncológicas, Madrid, Spain; and
  • Division of Cell Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
Venue
Blood
Publisher
American Society of Hematology
Published
2008-10-15
Volume
112
Issue
8
Pages
3217-3226
ISSN
  • 0006-4971
  • 1528-0020
DOI
10.1182/blood-2008-02-139394
Cited by
101
References
0
Language
en

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