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Aberrant, persistent inclusion into lipid rafts limits the tumorigenic function of membrane type-1 matrix metalloproteinase in malignant cells.

Rozanov, Dmitri V, Deryugina, Elena I, Monosov, Edward Z, Marchenko, Natalia D, Strongin, Alex Y·2004·Experimental Cell Research
DOI 10.1016/j.yexcr.2003.10.006
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Abstract

Membrane type-1 matrix metalloproteinase (MT1-MMP) is a key enzyme in cell locomotion and tissue remodeling. Trafficking to the plasma membrane and internalization into the transient storage compartment both regulate the cell surface presentation of MT1-MMP. Our data indicate that mutant MT1-MMP lacking the cytoplasmic tail is recruited to the caveolae-enriched lipid raft membrane microdomains in breast carcinoma MCF7 cells. In contrast, the wild-type protease is not permanently associated with lipid rafts. Trafficking to lipid rafts correlated with poor internalization and the persistent presentation of MT1-MMP at the cell surface. The tail mutant efficiently functioned in inducing the activation of the latent proMMP-2 zymogen, matrix remodeling, and contraction of three-dimensional collagen lattices. Recruitment of the tail mutant to lipid raft antagonized, however, the cleavage of the plasma membrane-associated E-cadherin. These events limited the contribution of the tail mutant to cell locomotion and malignant growth. It is conceivable that the tail peptide sequence plays a crucial role in the translocations of MT1-MMP across the cell and contributes to coordinated cellular functions. It is tempting to hypothesize that the mechanisms involved in trafficking of MT1-MMP to caveolin-enriched lipid rafts may be targeted in a clinically advantageous manner.

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  • Deletion of the cytoplasmic tail did not affect the trafficking of MT1-MMP to the plasma membrane nor its ability to activate proMMP2, but the mutant proteins displayed a different distribution pattern on the cell surface and an impaired ability to mediate cell invasion compared to the wild-type protein.

    “Deletion of the cytoplasmic tail did not affect the trafficking of MT1-MMP to the plasma membrane nor its ability to activate proMMP2, but the mutant proteins displayed a different distribution pattern on the cell surface and an impaired ability to mediate cell invasion compared to the wild-type protein (59, 60).”

    From Identification of amino acid residues in the MT-loop of MT1-MMP critical for its ability to cleave low-density lipoprotein receptor (2022) · cites this paper as [60]

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Research works printed but not linked: 64

  1. Egeblad, 2002, New functions for the matrix metalloproteinases in cancer progression, Nat. Rev., Cancer, 2, 161, 10.1038/nrc745 · DOI · Paper page
  2. Nagase, 1999, Matrix metalloproteinases, J. Biol. Chem., 274, 21491, 10.1074/jbc.274.31.21491 · DOI
  3. Massova, 1998, Matrix metalloproteinases: structures, evolution, and diversification, FASEB J., 12, 1075, 10.1096/fasebj.12.12.1075 · DOI
  4. McCawley, 2001, Matrix metalloproteinases: they're not just for matrix anymore!, Curr. Opin. Cell Biol., 13, 534, 10.1016/S0955-0674(00)00248-9 · DOI · Paper page
  5. Hotary, 2000, Regulation of cell invasion and morphogenesis in a three-dimensional type I collagen matrix by membrane-type matrix metalloproteinases 1, 2, and 3, J. Cell Biol., 149, 1309, 10.1083/jcb.149.6.1309 · DOI
  6. Hotary, 1999, Matrix metalloproteinases (MMPs) regulate fibrin-invasive activity via MT1-MMP-dependent and -independent processes, J. Exp. Med., 195, 295, 10.1084/jem.20010815 · DOI
  7. Deryugina, 2003, Prinomastat, a hydroxamate inhibitor of matrix metalloproteinases, has a complex effect on migration of breast carcinoma cells, Int. J. Cancer, 104, 533, 10.1002/ijc.10977 · DOI
  8. Sato, 1994, A matrix metalloproteinase expressed on the surface of invasive tumour cells, Nature, 370, 61, 10.1038/370061a0 · DOI
  9. Hernandez-Barrantes, 2002, Regulation of membrane type-matrix metalloproteinases, Semin. Cancer Biol., 12, 131, 10.1006/scbi.2001.0421 · DOI
  10. Seiki, 2003, Role of pericellular proteolysis by membrane-type 1 matrix metalloproteinase in cancer invasion and angiogenesis, Cancer Metastasis Rev., 22, 129, 10.1023/A:1023087113214 · DOI
  11. Seiki, 2003, Membrane-type 1 matrix metalloproteinase: a key enzyme for tumor invasion, Cancer Lett., 194, 1, 10.1016/S0304-3835(02)00699-7 · DOI
  12. Knauper, 2002, Cellular activation of proMMP-13 by MT1-MMP depends on the C-terminal domain of MMP-13, FEBS Lett., 532, 127, 10.1016/S0014-5793(02)03654-2 · DOI
  13. Strongin, 1995, Mechanism of cell surface activation of 72-kDa type IV collagenase. Isolation of the activated form of the membrane metalloprotease, J. Biol. Chem., 270, 5331, 10.1074/jbc.270.10.5331 · DOI
  14. Kajita, 2001, Membrane-type 1 matrix metalloproteinase cleaves CD44 and promotes cell migration, J. Cell Biol., 153, 893, 10.1083/jcb.153.5.893 · DOI
  15. Belkin, 2001, Matrix-dependent proteolysis of surface transglutaminase by membrane-type metalloproteinase regulates cancer cell adhesion and locomotion, J. Biol. Chem., 276, 18415, 10.1074/jbc.M010135200 · DOI
  16. Ito, 1999, Calcium influx triggers the sequential proteolysis of extracellular and cytoplasmic domains of E-cadherin, leading to loss of beta-catenin from cell–cell contacts, Oncogene, 18, 7080, 10.1038/sj.onc.1203191 · DOI
  17. Steinhusen, 2001, Cleavage and shedding of E-cadherin after induction of apoptosis, J. Biol. Chem., 276, 4972, 10.1074/jbc.M006102200 · DOI
  18. Ratnikov, 2002, An alternative processing of integrin alpha(v) subunit in tumor cells by membrane type-1 matrix metalloproteinase, J. Biol. Chem., 277, 7377, 10.1074/jbc.M109580200 · DOI
  19. Deryugina, 2002, Processing of integrin alpha(v) subunit by membrane type 1 matrix metalloproteinase stimulates migration of breast carcinoma cells on vitronectin and enhances tyrosine phosphorylation of focal adhesion kinase, J. Biol. Chem., 277, 9749, 10.1074/jbc.M110269200 · DOI
  20. Pei, 1995, Furin-dependent intracellular activation of the human stromelysin-3 zymogen, Nature, 375, 244, 10.1038/375244a0 · DOI
  21. Bassi, 2001, Furin inhibition results in absent or decreased invasiveness and tumorigenicity of human cancer cells, Proc. Natl. Acad. Sci. U. S. A., 98, 10326, 10.1073/pnas.191199198 · DOI
  22. Rozanov, 2001, J. Biol. Chem., 276, 25705, 10.1074/jbc.M007921200 · DOI
  23. Rozanov, 2003, Membrane type-1 matrix metalloproteinase functions as a proprotein self-convertase. Expression of the latent zymogen in Pichia pastoris, autolytic activation, and the peptide sequence of the cleavage forms, J. Biol. Chem., 278, 8257, 10.1074/jbc.M213246200 · DOI · Paper page
  24. Sato, 1999, Furin-independent pathway of membrane type 1-matrix metalloproteinase activation in rabbit dermal fibroblasts, J. Biol. Chem., 274, 37280, 10.1074/jbc.274.52.37280 · DOI
  25. Yana, 2000, Regulation of membrane type-1 matrix metalloproteinase activation by proprotein convertases, Mol. Biol. Cell, 11, 2387, 10.1091/mbc.11.7.2387 · DOI
  26. Zucker, 1998, Tissue inhibitor of metalloproteinase-2 (TIMP-2) binds to the catalytic domain of the cell surface receptor, membrane type 1-matrix metalloproteinase 1 (MT1-MMP), J. Biol. Chem., 273, 1216, 10.1074/jbc.273.2.1216 · DOI
  27. Toth, 2002, Complex pattern of membrane type 1 matrix metalloproteinase shedding. Regulation by autocatalytic cells surface inactivation of active enzyme, J. Biol. Chem., 277, 26340, 10.1074/jbc.M200655200 · DOI · Paper page
  28. Jiang, 2001, Regulation of membrane-type matrix metalloproteinase 1 activity by dynamin-mediated endocytosis, Proc. Natl. Acad. Sci. U. S. A., 98, 13693, 10.1073/pnas.241293698 · DOI
  29. Maquoi, 1999, Regulation of membrane-type 1 matrix metalloproteinase activity by vacuolar H+-ATPases, Biochem. J., 373, 19, 10.1042/bj20030170 · DOI
  30. Zucker, 2002, Rapid trafficking of membrane type 1-matrix metalloproteinase to the cell surface regulates progelatinase A activation, Lab. Invest., 82, 1673, 10.1097/01.LAB.0000041713.74852.2A · DOI
  31. Urena, 1999, The cytoplasmic carboxy-terminal amino acid determines the subcellular localization of proTGF-(alpha) and membrane type matrix metalloprotease (MT1-MMP), J. Cell Sci., 112, 773, 10.1242/jcs.112.6.773 · DOI
  32. Rozanov, 2002, The cytoplasmic tail peptide sequence of membrane type-1 matrix metalloproteinase (MT1-MMP) directly binds to gC1qR, a compartment- specific chaperone-like regulatory protein, FEBS Lett., 527, 51, 10.1016/S0014-5793(02)03153-8 · DOI
  33. Seiki, 2003, Roles of pericellular proteolysis by membrane type-1 matrix metalloproteinase in cancer invasion and angiogenesis, Cancer Sci., 94, 569, 10.1111/j.1349-7006.2003.tb01484.x · DOI
  34. Rozanov, 2002, The hemopexin-like C-terminal domain of membrane type 1 matrix metalloproteinase regulates proteolysis of a multifunctional protein, gC1qR, J. Biol. Chem., 277, 9318, 10.1074/jbc.M110711200 · DOI
  35. Deryugina, 2002, Up-regulation of vascular endothelial growth factor by membrane-type 1 matrix metalloproteinase stimulates human glioma xenograft growth and angiogenesis, Cancer Res., 62, 580
  36. Deryugina, 2001, MT1-MMP initiates activation of pro-MMP-2 and integrin alphavbeta3 promotes maturation of MMP-2 in breast carcinoma cells, Exp. Cell Res., 263, 209, 10.1006/excr.2000.5118 · DOI
  37. Deryugina, 1997, Matrix metalloproteinase-2 activation modulates glioma cell migration, J. Cell Sci., 110, 2473, 10.1242/jcs.110.19.2473 · DOI
  38. Deryugina, 1998, Remodeling of collagen matrix by human tumor cells requires activation and cell surface association of matrix metalloproteinase-2, Cancer Res., 58, 3743
  39. Sounni, 2002, MT1-MMP expression promotes tumor growth and angiogenesis through an up-regulation of vascular endothelial growth factor expression, FASEB J., 16, 555, 10.1096/fj.01-0790com · DOI
  40. Galbiati, 2000, Caveolin-1 expression inhibits Wnt/beta-catenin/Lef-1 signaling by recruiting beta-catenin to caveolae membrane domains, J. Biol. Chem., 275, 23368, 10.1074/jbc.M002020200 · DOI
  41. Bordier, 1981, Phase separation of integral membrane proteins in Triton X-114 solution, J. Biol. Chem., 256, 1604, 10.1016/S0021-9258(19)69848-0 · DOI
  42. Bricker, 1984, Triton X-114 phase fractionation of membrane proteins of the cyanobacterium Anacystis nidulans R2, Arch. Biochem. Biophys., 235, 204, 10.1016/0003-9861(84)90269-8 · DOI
  43. Wolf, 2003, Compensation mechanism in tumor cell migration: mesenchymal-amoeboid transition after blocking of pericellular proteolysis, J. Cell Biol., 160, 267, 10.1083/jcb.200209006 · DOI
  44. Marella, 2002, Filipin prevents pathological prion protein accumulation by reducing endocytosis and inducing cellular PrP release, J. Biol. Chem., 277, 25457, 10.1074/jbc.M203248200 · DOI
  45. Annabi, 2001, Localization of membrane-type 1 matrix metalloproteinase in caveolae membrane domains, Biochem. J., 353, 547, 10.1042/bj3530547 · DOI
  46. Puyraimond, 2001, MMP-2 colocalizes with caveolae on the surface of endothelial cells, Exp. Cell Res., 262, 28, 10.1006/excr.2000.5069 · DOI
  47. Marchenko, 2003, The human and mouse matrix metalloproteinase MMP-21: the structure and the regulation of the gene and the protein, Biochem. J., 372, 503, 10.1042/bj20030174 · DOI
  48. Lehti, 2002, Oligomerization through hemopexin and cytoplasmic domains regulates the activity and turnover of membrane-type 1 matrix metalloproteinase, J. Biol. Chem., 277, 8440, 10.1074/jbc.M109128200 · DOI
  49. Holmbeck, 1999, MT1-MMP-deficient mice develop dwarfism, osteopenia, arthritis, and connective tissue disease due to inadequate collagen turnover, Cell, 99, 81, 10.1016/S0092-8674(00)80064-1 · DOI · Paper page
  50. Will, 1996, The soluble catalytic domain of membrane type 1 matrix metalloproteinase cleaves the propeptide of progelatinase A and initiates autoproteolytic activation. Regulation by TIMP-2 and TIMP-3, J. Biol. Chem., 271, 17119, 10.1074/jbc.271.29.17119 · DOI
  51. Mori, 2002, CD44 directs membrane-type 1 matrix metalloproteinase to lamellipodia by associating with its hemopexin-like domain, EMBO J., 21, 3949, 10.1093/emboj/cdf411 · DOI · Paper page
  52. Nakahara, 1997, Transmembrane/cytoplasmic domain-mediated membrane type 1-matrix metalloprotease docking to invadopodia is required for cell invasion, Proc. Natl. Acad. Sci. U. S. A., 94, 7959, 10.1073/pnas.94.15.7959 · DOI
  53. Takahashi, 2002, Identification of membrane-type matrix metalloproteinase-1 as a target of the beta-catenin/Tcf4 complex in human colorectal cancers, Oncogene, 21, 5861, 10.1038/sj.onc.1205755 · DOI
  54. Kang, 2002, Activation of membrane-type matrix metalloproteinase 3 zymogen by the proprotein convertase furin in the trans-Golgi network, Cancer Res., 62, 675
  55. Pei, 1996, Transmembrane-deletion mutants of the membrane-type matrix metalloproteinase-1 process progelatinase A and express intrinsic matrix-degrading activity, J. Biol. Chem., 271, 9135, 10.1074/jbc.271.15.9135 · DOI
  56. Uekita, 2001, Cytoplasmic tail-dependent internalization of membrane-type 1 matrix metalloproteinase is important for its invasion-promoting activity, J. Cell Biol., 155, 1345, 10.1083/jcb.200108112 · DOI
  57. Galbiati, 2001, Emerging themes in lipid rafts and caveolae, Cell, 106, 403, 10.1016/S0092-8674(01)00472-X · DOI
  58. Kurzchalia, 1999, Membrane microdomains and caveolae, Curr. Opin. Cell Biol., 11, 424, 10.1016/S0955-0674(99)80061-1 · DOI
  59. Razani, 2001, Caveolins and caveolae: molecular and functional relationships, Exp. Cell Res., 271, 36, 10.1006/excr.2001.5372 · DOI
  60. Shiao, 1993, Sphingomyelin transport to the cell surface occurs independently of protein secretion in rat hepatocytes, J. Biol. Chem., 268, 26085, 10.1016/S0021-9258(19)74284-7 · DOI
  61. Morrow, 2002, Flotillin-1/reggie-2 traffics to surface raft domains via a novel golgi-independent pathway. Identification of a novel membrane targeting domain and a role for palmitoylation, J. Biol. Chem., 277, 48834, 10.1074/jbc.M209082200 · DOI
  62. Smart, 1999, Caveolins, liquid-ordered domains, and signal transduction, Mol. Cell. Biol., 19, 7289, 10.1128/MCB.19.11.7289 · DOI
  63. Anderson, 1998, The caveolae membrane system, Annu. Rev. Biochem., 67, 199, 10.1146/annurev.biochem.67.1.199 · DOI
  64. Friedl, 2003, Tumour-cell invasion and migration: diversity and escape mechanisms, Nat. Rev., Cancer, 3, 362, 10.1038/nrc1075 · DOI

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Metadata

Authors
Rozanov, D. V., Deryugina, E. I., Monosov, E. Z., Marchenko, N. D., & Strongin, A. Y.
Venue
Experimental Cell Research
Publisher
Elsevier BV
Published
2004-02
Volume
293
Issue
1
Pages
81-95
ISSN
0014-4827
DOI
10.1016/j.yexcr.2003.10.006
Cited by
64
References
1
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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