Cited by 1,089Erythrocyte Function and PathophysiologyLipid Membrane Structure and BehaviorHemoglobinopathies and Related Disorders

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Red cell membrane: past, present, and future

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Mohandas, Narla, Gallagher, Patrick G.·2008·Blood

DOI 10.1182/blood-2008-07-161166PMC PMC2582001

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Abstract

As a result of natural selection driven by severe forms of malaria, 1 in 6 humans in the world, more than 1 billion people, are affected by red cell abnormalities, making them the most common of the inherited disorders. The non-nucleated red cell is unique among human cell type in that the plasma membrane, its only structural component, accounts for all of its diverse antigenic, transport, and mechanical characteristics. Our current concept of the red cell membrane envisions it as a composite structure in which a membrane envelope composed of cholesterol and phospholipids is secured to an elastic network of skeletal proteins via transmembrane proteins. Structural and functional characterization of the many constituents of the red cell membrane, in conjunction with biophysical and physiologic studies, has led to detailed description of the way in which the remarkable mechanical properties and other important characteristics of the red cells arise, and of the manner in which they fail in disease states. Current studies in this very active and exciting field are continuing to produce new and unexpected revelations on the function of the red cell membrane and thus of the cell in health and disease, and shed new light on membrane function in other diverse cell types.

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Authors: Mohandas, N., & Gallagher, P. G.
Affiliations: New York Blood Center (US)
Yale University (US)
ORCID: Mohandas, Narla
Gallagher, Patrick G.
Venue: Blood
Publisher: American Society of Hematology
Published: 2008-11-15
Volume: 112
Issue: 10
Pages: 3939-3948
ISSN: 0006-4971 (ISSN-L)
1528-0020
DOI: 10.1182/blood-2008-07-161166
PMC: PMC2582001
OpenAlex: W2022066534
Cited by: 1,089
References: 104
Citations by year: 2026: 67 · 2025: 61 · 2024: 48 · 2023: 70 · 2022: 75 · 2021: 71 · 2020: 71 · 2019: 70 · 2018: 66 · 2017: 62 · 2016: 66 · 2015: 60 · 2014: 65 · 2013: 61 · 2012: 62
FWCI: 4.05
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Blood (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: University of Washington
National Institutes of Health
National Heart, Lung, and Blood Institute (R01HL031579)
National Institute of Diabetes and Digestive and Kidney Diseases (R37DK026263, P01DK032094, R01DK026263, R01DK062039)
Topics: Health Sciences › Medicine › Physiology (medical) › Erythrocyte Function and Pathophysiology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
Health Sciences › Medicine › Genetics (clinical) › Hemoglobinopathies and Related Disorders
Keywords: erythrocyte membrane, erythrocyte membrane structure, malaria resistance, membrane mechanics, membrane skeleton, transmembrane proteins, membrane transport, membrane biophysics
MeSH terms: Biological Transport, Erythrocyte Membrane, Erythrocytes, Abnormal, Humans, Isoantigens, Malaria, Membrane Proteins, Selection, Genetic, Structure-Activity Relationship

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