Pathophysiologic Implications of Membrane Phospholipid Asymmetry in Blood Cells
Abstract
MANY STUDIES HAVE led to the concept that membrane phospholipid asymmetry is ubiquitous. In general terms, the outer leaflet of eukaryotic plasma membranes is formed predominantly with the cholinephospholipids (sphingomyelin and phosphatidylcholine [PC]), whereas the majority of the
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Microvesicle formation involves phosphatidylserine translocation to the outer membrane leaflet and completion by actin-myosin cytoskeletal contraction.
“Membrane budding/vesicle formation is induced by translocation of phosphatidylserine to the outer-membrane leaflet [62, 65]. The budding process is completed through contraction of cytoskeletal structures by actin-myosin interactions [66, 67].”
From Biogenesis of extracellular vesicles (EV): exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies (2013) · cites this paper as [62]
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“Membrane budding/vesicle formation is induced by translocation of phosphatidylserine to the outer-membrane leaflet [62, 65].”
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- Authors
- Zwaal, R. F. A., & Schroit, A. J.
- Affiliations
- The University of Texas MD Anderson Cancer Center (US)
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 1997-02-15
- Volume
- 89
- Issue
- 4
- Pages
- 1121-1132
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W165853039
- Cited by
- 1,340
- References
- 0
- Citations by year
- 2026: 11 · 2025: 19 · 2024: 13 · 2023: 21 · 2022: 34 · 2021: 23 · 2020: 31 · 2019: 32 · 2018: 36 · 2017: 47 · 2016: 40 · 2015: 55 · 2014: 53 · 2013: 62 · 2012: 55
- FWCI
- 16.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Blood (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01dk041714-09)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-41714)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
- Health Sciences › Medicine › Physiology › Erythrocyte Function and Pathophysiology
- Health Sciences › Medicine › Hematology › Platelet Disorders and Treatments
- Keywords
- membrane phospholipid asymmetry, blood cells, plasma membrane, outer leaflet, sphingomyelin, phosphatidylcholine, choline phospholipids, pathophysiology
- MeSH terms
- Blood Cells, Calcium, Carrier Proteins, Complement Activation, Endothelium, Vascular, Hemostasis, Humans, Lipid Bilayers, Macrophages, Membrane Lipids, Membrane Proteins, Models, Biological, Phosphatidylethanolamines, Phosphatidylserines, Phospholipids, Surface Properties, Thrombosis, Apoptosis, Phospholipid Transfer Proteins
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