Cited by 363Retinoids in leukemia and cellular processesAcute Myeloid Leukemia ResearchAcute Lymphoblastic Leukemia research

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Differentiation syndrome in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and anthracycline chemotherapy: characteristics, outcome, and prognostic factors

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Montesinos, Pau, Bergua, Juan M., Vellenga, Edo, Rayón, Chelo, Parody, Ricardo, de la Serna, Javier, León, Angel, Esteve, Jordi, Milone, Gustavo, Debén, Guillermo, Rivas, Concha, González, Marcos, Tormo, Mar, Díaz-Mediavilla, Joaquín, González, Jose D., Negri, Silvia, Amutio, Elena, Brunet, Salut, Lowenberg, Bob, Sanz, Miguel A.·2009·Blood

DOI 10.1182/blood-2008-07-168617

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Abstract

Differentiation syndrome (DS) can be a life-threatening complication in patients with acute promyelocytic leukemia (APL) undergoing induction therapy with all-trans retinoic acid (ATRA). Detailed knowledge about DS has remained limited. We present an analysis of the incidence, characteristics, prognostic factors, and outcome of 739 APL patients treated with ATRA plus idarubicin in 2 consecutive trials (Programa Español de Tratamientos en Hematología [PETHEMA] LPA96 and LPA99). Overall, 183 patients (24.8%) experienced DS, 93 with a severe form (12.6%) and 90 with a moderate form (12.2%). Severe but not moderate DS was associated with an increase in mortality. A bimodal incidence of DS was observed, with peaks occurring in the first and third weeks after the start of ATRA therapy. A multivariate analysis indicated that a WBC count greater than 5 × 109/L and an abnormal serum creatinine level correlated with an increased risk of developing severe DS. Patients receiving systematic prednisone prophylaxis (LPA99 trial) in contrast to those receiving selective prophylaxis with dexamethasone (LPA96 trial) had a lower incidence of severe DS. Patients developing severe DS showed a reduced 7-year relapse-free survival in the LPA96 trial (60% vs 85%, P = .003), but this difference was not apparent in the LPA99 trial (86% vs 88%).

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Nonparametric Estimation from Incomplete Observations
Kaplan, E. L., & Meier, P. (1992) · Springer series in statistics · doi:10.1007/978-1-4612-4380-9_25 · Cited by 45,239
Regression Models and Life-Tables
Cox, D. R. (1972) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1972.tb00899.x · Cited by 39,793
Nonparametric Estimation from Incomplete Observations
Kaplan, E. L., & Meier, P. (1958) · Journal of the American Statistical Association · doi:10.1080/01621459.1958.10501452 · Cited by 39,158
Regression Models and Life-Tables
Cox, D. R. (1992) · Springer Series in Statistics · doi:10.1007/978-1-4612-4380-9_37 · Cited by 26,297
Proposals for the Classification of the Acute Leukaemias F rench ‐A merican ‐B ritish (FAB) C o‐operative G roup
Bennett, J. M., Catovsky, D., Mt, D., Flandrin, G., Galton, D. A. G., Gralnick, H. R., & Sultan, C. (1976) · British Journal of Haematology · doi:10.1111/j.1365-2141.1976.tb03563.x · Cited by 5,595
BMDP Statistical Software 1981.
Bubolz, T. A., & Dixon, W. J. (1984) · Journal of the American Statistical Association · doi:10.2307/2288308 · Cited by 5,231
Statistical Methods for Survival Data Analysis.
Lachenbruch, P. A., & Lee, E. T. (1993) · Journal of the American Statistical Association · doi:10.2307/2290742 · Cited by 2,851
Analysis of Binary Data
Cox, D. R. (2008) · Springer eBooks · doi:10.1007/978-0-387-32833-1_5 · Cited by 2,687
Revised Recommendations of the International Working Group for Diagnosis, Standardization of Response Criteria, Treatment Outcomes, and Reporting Standards for Therapeutic Trials in Acute Myeloid Leukemia
Cheson, B. D., Bennett, J. M., Kopecky, K. J., Büchner, T., Willman, C. L., Estey, E. H., Schiffer, C. A., Döhner, H., Tallman, M. S., Lister, T. A., et al. (2003) · Journal of Clinical Oncology · doi:10.1200/jco.2003.04.036 · Cited by 2,686
Self-citation
Revised Recommendations of the International Working Group for Diagnosis, Standardization of Response Criteria, Treatment Outcomes, and Reporting Standards for Therapeutic Trials in Acute Myeloid Leukemia
Creutzig, U., & Kaspers, G. J. L. (2004) · Journal of Clinical Oncology · doi:10.1200/jco.2004.99.116 · Cited by 2,137

Show all 42 references

Research works printed but not linked: 1

Dixon, 1990, BMDP Statistical Software

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Random small interfering RNA library screen identifies siRNAs that induce human erythroleukemia cell differentiation
Fan, C., Xiong, Y., Zhu, N., Lü, Y., Zhang, J., Wang, S., Liang, Z., Shen, Y., & Chen, M. (2011) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.3109/10428194.2010.543712 · Cited by 2
Promyelocytic sarcoma presenting with spinal cord compression and treated successfully with surgical debulking and the PETHEMA regimen for acute promyelocytic leukemia
Cornfield, D. B., Gheith, S. M. F., & Barron, L. (2015) · Case Reports in Clinical Pathology · doi:10.5430/crcp.v2n3p12 · Cited by 2
Management of differentiation syndrome in an elderly patient with acute promyelocytic leukemia who subsequently developed refractory anemia with ring sideroblasts
Denu, R. A., Lobo, R. H., & Mattison, R. J. (2016) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.3109/10428194.2016.1165813 · Cited by 2
Impact of an Alert System on Quality Indicators in Patients With Acute Promyelocytic Leukemia
Blackburn, L. M., Bauchmire, N., Bender, S., Tomlinson-Pinkham, K., Roberts, S., & Rosan, S. (2016) · Clinical journal of oncology nursing · doi:10.1188/16.cjon.523-527 · Cited by 2
Increased CD13 Expression in Acute Myeloid Leukemia–associated Early Acute Hypoxic Respiratory Failure
Schneider, C. W., Bayerl, M. G., Boyer, C. M., Desai, R. J., Claxton, D. F., & de Louw, A. V. (2017) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201701-0080le · Cited by 2
Consensus in acute myeloid leukemia in Mexico
Arana-Luna, L. L., Alvarado‐Ibarra, M., Silva-Michel, L. G., Morales-Maravilla, A., González-Rubio, M. D. C., Chávez-Aguilar, L. A., Tena-Iturralde, M. F., Mojica-Balceras, L., Zapata-Canto, N., Galindo-Delgado, P., et al. (2022) · Gaceta Médica de México · doi:10.24875/gmm.m21000598 · Cited by 2
Charlson comorbidity index predicts early mortality and overall survival in acute promyelocytic leukemia
Dhakal, P., Lyden, E. R., Joshi, U., Pyakuryal, A., Gundabolu, K., & Bhatt, V. R. (2022) · Leukemia Research · doi:10.1016/j.leukres.2022.106927 · Cited by 2
Complications during Induction Chemotherapy in Acute Promyelocytic Leukemia: An Institutional Experience
Yedla, R. P., Bala, S. C., Pydi, V. R., Chennamaneni, R., Kuruva, S. P., Konatam, M. L., & Gundeti, S. (2022) · South Asian Journal of Cancer · doi:10.1055/s-0042-1757303 · Cited by 2
Pediatric Acute Myeloid Leukemia: How to Improve Outcome?
Szalontay, L., & Shad, A. T. (2013) · Current Pediatrics Reports · doi:10.1007/s40124-013-0036-2 · Cited by 2
Acitretin induced lung injury by differentiation syndrome
Khan, S. Z., Guddati, A. K., & Marak, C. P. (2020) · Respiratory Medicine Case Reports · doi:10.1016/j.rmcr.2020.101138 · Cited by 2
Acute promyelocytic leukemia. State of the art
Buriticá, L. M., Torres, J. D., & Vásquez, G. (2021) · Institutional Repository University of Antioquia (University of Antioquia) · doi:10.17533/udea.iatreia.76 · Cited by 2
Differentiation Syndrome with Ocular Manifestations in Acute Promyelocytic Leukemia Patients Treated with All-trans Retinoic Acid
Oh, S. E., & Choi, S. Y. (2021) · Journal of the Korean Ophthalmological Society · doi:10.3341/jkos.2021.62.4.571 · Cited by 1
Management of Acute Promyelocytic Leukemia
Käyser, S., & Platzbecker, U. (2021) · Hematologic malignancies · doi:10.1007/978-3-030-72676-8_8 · Cited by 1
Acute promyelocytic leukemia in children cancer hospital Egypt
Semary, S., Hammad, M., Yassin, D., Sharkawy, N. E., Soliman, S., Salem, S., Ezzat, E., Mosa, A., & Ahmed, S. (2024) · Discover Oncology · doi:10.1007/s12672-024-01037-6 · Cited by 1
Predictors of Differentiation Syndrome in Patients with Acute Promyelocytic Leukemia Following Induction Therapy: A Meta-Analysis
Alghwyeen, W., Mohamed, S. F., Hashim, A. S., Aboali, A. A., Alahdab, G. M., & Salloum, O. H. (2025) · Indian Journal of Hematology and Blood Transfusion · doi:10.1007/s12288-025-02036-5 · Cited by 1
Does differentiation syndrome in newly diagnosed acute promyelocytic leukemia warrant systemic antifungal therapy? A real-world clinical study
Jiang, Y., Luo, C., Yan, H., Zhu, L., Hu, X., Xue, L., Tong, J., & Zheng, C. (2026) · Annals of Hematology · doi:10.1007/s00277-026-06729-3 · Cited by 1
Efficacy and safety of ATRA plus arsenic trioxide versus ATRA plus chemotherapy in newly diagnosed acute promyelocytic leukemia: a grade-assessed systematic review and meta-analysis
Ahmad, H., Henna, F., Khurram, S., Khan, A. I., Ahmed, A., Ali, M. H., Hassan, M. A., Abbas, M., Farooq, D., Muhammad, S., et al. (2026) · BMC Cancer · doi:10.1186/s12885-026-15932-4 · Cited by 1
Beyond Bleeding: Underrecognized Thrombotic Complications in Acute Promyelocytic Leukemia — A Single-Center Experience from the GCC Region
Mohamed, S. F., Al-Shebly, R., Shawaylia, H., Elahie, A., Ghasoub, R. S., Soliman, D., Mudawi, D., Abdulgayoom, M., Al-Mashdali, A. F., Rabadi, M., et al. (2026) · Clinical and Applied Thrombosis/Hemostasis · doi:10.1177/10760296261439468 · Cited by 1
Modern Concepts in Precision Targeting of Acute Myeloid Leukemia Based on Principles of Molecular Oncology
Yuan, R., Mariano, M., Cachia, D., Badar, T., & Patel, S. A. (2026) · Cancers · doi:10.3390/cancers18142329 · Cited by 1
Severe Pulmonary Differentiation Syndrome Despite Corticosteroid Prophylaxis in Acute Promyelocytic Leukemia: Clinical Improvement With Pulse Methylprednisolone Therapy and High-Flow Nasal Cannula
Cardozo, P., Reynolds, L., Rivera, C., Berrio, C., & Hurtado, F. (2026) · Cureus · doi:10.7759/cureus.113285 · Cited by 1
Strategy to further increase of cure rate in acute promyelocytic leukaemia: low‐dose all‐trans retinoic acid and sequential maintenance cycle
Zheng, C., Liu, X., Zhu, W., Wu, J., Cai, X., & Sun, Z. (2010) · British Journal of Haematology · doi:10.1111/j.1365-2141.2010.08375.x · Cited by 1
Primary multiple cerebral invasion in acute promyelocytic leukemia dramatically worsened by all-trans retinoic acid
Kakimoto, T., Takahashi, Y., Watanabe, H., Matsuzawa, M., Sanada, Y., Suzuki, K., Mihara, A., Yoshida, S., & Nakazato, T. (2009) · Leukemia Research · doi:10.1016/j.leukres.2009.11.023 · Cited by 1
Sehr schweres Differenzierungssyndrom bei Niedrigrisiko akuter Promyelozytenleukämie – eine Tücke der differenzierenden Therapie
Hecht, A., Mezger, J., Gnadler, M., & Lengfelder, E. (2017) · DMW - Deutsche Medizinische Wochenschrift · doi:10.1055/s-0042-121365 · Cited by 1
[Establishment and assessment of a nomogram for predicting the differentiation syndrome of acute promyelocytic leukemia].
Bao, X., Hu, X. H., Tian, C. Y., Ji, Y., Chen, S., Qiu, H. Y., Sun, A., & Wu, D. (2016) · PubMed Central · doi:10.3760/cma.j.issn.0253-2727.2016.11.007 · Cited by 1
Complications and Toxicities Associated with Cancer Therapies in the Intensive Care Unit
Rivera, M. J., Smack, M. A., Lee, B., Anderson, T., Highsmith, E. A., Chen, A., Do, B., Bryan, J. C., Shigle, T. L., & Patel, R. P. (2019) · Springer eBooks · doi:10.1007/978-3-319-74588-6_21 · Cited by 1
Haematological Emergencies
Tay, H. M. (2014) · Proceedings of Singapore Healthcare · doi:10.1177/201010581402300105 · Cited by 1
Sindromul coronarian acut – o complicaţie rară în leucemia acută promielocitară
Minodora, A. S., Cîşleanu, D., Nicolescu, A., Voican, I., Neagu, A. M., Neculcea, A., Mititelu, A., Enache, C., Darabont, R., Mihalcea, D. J., et al. (2023) · Oncolog-Hematolog ro · doi:10.26416/onhe.63.2.2023.8093 · Cited by 1
Risk factors for a differentiation syndrome in patients with acute promyelocytic leukemia
Semenova, A. A., Troitskaya, V. V., Galtseva, I. V., & Parovichnikova, E. N. (2023) · Oncohematology · doi:10.17650/1818-8346-2023-18-3-50-56 · Cited by 1
Ivosidenib in relapsed or refractory acute myeloid leukemia: a profile of its use in the USA
McCafferty, E. H., & Lyseng-Williamson, K. A. (2019) · Drugs & Therapy Perspectives · doi:10.1007/s40267-019-00610-2 · Cited by 1
Current and emerging treatments for acute promyelocytic leukemia
Yilmaz, M. E., Naqvi, K., & Ravandi, F. (2019) · Expert Opinion on Orphan Drugs · doi:10.1080/21678707.2019.1684261 · Cited by 1

Authors: Montesinos, P., Bergua, J. M., Vellenga, E., Rayón, C., Parody, R., de la Serna, J., León, A., Esteve, J., Milone, G., Debén, G., Rivas, C., González, M., Tormo, M., Díaz-Mediavilla, J., González, J. D., Negri, S., Amutio, E., Brunet, S., Lowenberg, B., & Sanz, M. A.
Affiliations: Universitat Autònoma de Barcelona (ES)
Hospital San Pedro de Alcántara (ES)
University Medical Center Groningen (NL)
Hospital Universitario Central de Asturias (ES)
Hospital Universitario Virgen del Rocío (ES)
Hospital 12 de Octubre, Madrid, Spain;
Hospital General, Jerez de la Frontera, Spain;
Hospital Clínic de Barcelona (ES)
Fundaleu, Buenos Aires, Argentina;
Hospital Juan Canalejo, La Coruña, Spain;
Hospital General Universitario de Alicante Doctor Balmis (ES)
Hospital Universitario, Salamanca, Spain;
Hospital Clínico Universitario de Valencia (ES)
Hospital Clínico San Carlos, Madrid, Spain;
Hospital Insular, Las Palmas, Spain;
Hospital Carlos Haya, Málaga, Spain;
Hospital de Cruces (ES)
Hospital de Sant Pau (ES)
Erasmus University Medical Center, Rotterdam, The Netherlands
Hospital Universitario La Fe, Valencia, Spain;
ORCID: Montesinos, Pau
Bergua, Juan M.
Vellenga, Edo
Esteve, Jordi
González, Marcos
Tormo, Mar
Negri, Silvia
Brunet, Salut
Venue: Blood
Publisher: American Society of Hematology
Published: 2009-01-22
Volume: 113
Issue: 4
Pages: 775-783
ISSN: 0006-4971 (ISSN-L)
1528-0020
DOI: 10.1182/blood-2008-07-168617
OpenAlex: W1982745688
Cited by: 362
References: 42
Citations by year: 2026: 19 · 2025: 22 · 2024: 31 · 2023: 23 · 2022: 21 · 2021: 33 · 2020: 33 · 2019: 22 · 2018: 23 · 2017: 19 · 2016: 16 · 2015: 15 · 2014: 17 · 2013: 8 · 2012: 11
FWCI: 6.58
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Blood (publishedVersion)
PubMed (publishedVersion)
EUR Research Repository (Erasmus University Rotterdam) (publishedVersion, other-oa)
EUR Research Repository (Erasmus University Rotterdam) (submittedVersion, other-oa)
RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinoids in leukemia and cellular processes
Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
Health Sciences › Medicine › Hematology › Acute Lymphoblastic Leukemia research
Keywords: differentiation syndrome, acute promyelocytic leukemia, all-trans retinoic acid, idarubicin, anthracycline chemotherapy, prognostic factors, mortality, relapse-free survival, dexamethasone prophylaxis, serum creatinine, white blood cell count
MeSH terms: Adolescent, Adult, Aged, Aged, 80 and over, Child, Child, Preschool, Drug Therapy, Combination, Female, Humans, Male, Middle Aged, Prognosis, Recurrence, Risk Factors, Syndrome, Time Factors, Tretinoin, Leukemia, Promyelocytic, Acute, Disease-Free Survival, Anthracyclines

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Differentiation syndrome in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and anthracycline chemotherapy: characteristics, outcome, and prognostic factors

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