The DOI matches its Crossref record; 41 of the 42 references it cites were found in a registry or an index.
Differentiation syndrome in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and anthracycline chemotherapy: characteristics, outcome, and prognostic factors
Open accessAbstract
Differentiation syndrome (DS) can be a life-threatening complication in patients with acute promyelocytic leukemia (APL) undergoing induction therapy with all-trans retinoic acid (ATRA). Detailed knowledge about DS has remained limited. We present an analysis of the incidence, characteristics, prognostic factors, and outcome of 739 APL patients treated with ATRA plus idarubicin in 2 consecutive trials (Programa Español de Tratamientos en Hematología [PETHEMA] LPA96 and LPA99). Overall, 183 patients (24.8%) experienced DS, 93 with a severe form (12.6%) and 90 with a moderate form (12.2%). Severe but not moderate DS was associated with an increase in mortality. A bimodal incidence of DS was observed, with peaks occurring in the first and third weeks after the start of ATRA therapy. A multivariate analysis indicated that a WBC count greater than 5 × 109/L and an abnormal serum creatinine level correlated with an increased risk of developing severe DS. Patients receiving systematic prednisone prophylaxis (LPA99 trial) in contrast to those receiving selective prophylaxis with dexamethasone (LPA96 trial) had a lower incidence of severe DS. Patients developing severe DS showed a reduced 7-year relapse-free survival in the LPA96 trial (60% vs 85%, P = .003), but this difference was not apparent in the LPA99 trial (86% vs 88%).
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“RA is a potential treatment, combined with other drugs, for AML98 and chronic myeloid leukemia99.”
From Advances and challenges in retinoid delivery systems in regenerative and therapeutic medicine (2020) · cites this paper as [98]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Nonparametric Estimation from Incomplete Observations
Kaplan, E. L., & Meier, P. (1992) · Springer series in statistics · doi:10.1007/978-1-4612-4380-9_25 · Cited by 45,239
Regression Models and Life-Tables
Cox, D. R. (1972) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1972.tb00899.x · Cited by 39,793
Nonparametric Estimation from Incomplete Observations
Kaplan, E. L., & Meier, P. (1958) · Journal of the American Statistical Association · doi:10.1080/01621459.1958.10501452 · Cited by 39,158
Regression Models and Life-Tables
Cox, D. R. (1992) · Springer Series in Statistics · doi:10.1007/978-1-4612-4380-9_37 · Cited by 26,297
Bennett, J. M., Catovsky, D., Mt, D., Flandrin, G., Galton, D. A. G., Gralnick, H. R., & Sultan, C. (1976) · British Journal of Haematology · doi:10.1111/j.1365-2141.1976.tb03563.x · Cited by 5,595
BMDP Statistical Software 1981.
Bubolz, T. A., & Dixon, W. J. (1984) · Journal of the American Statistical Association · doi:10.2307/2288308 · Cited by 5,231
Statistical Methods for Survival Data Analysis.
Lachenbruch, P. A., & Lee, E. T. (1993) · Journal of the American Statistical Association · doi:10.2307/2290742 · Cited by 2,851
Cox, D. R. (2008) · Springer eBooks · doi:10.1007/978-0-387-32833-1_5 · Cited by 2,687
Cheson, B. D., Bennett, J. M., Kopecky, K. J., Büchner, T., Willman, C. L., Estey, E. H., Schiffer, C. A., Döhner, H., Tallman, M. S., Lister, T. A., et al. (2003) · Journal of Clinical Oncology · doi:10.1200/jco.2003.04.036 · Cited by 2,686
Self-citationCreutzig, U., & Kaspers, G. J. L. (2004) · Journal of Clinical Oncology · doi:10.1200/jco.2004.99.116 · Cited by 2,137
Research works printed but not linked: 1
- Dixon, 1990, BMDP Statistical Software
Cited by
Sorted by citations
Items 301–363 of 363
Toxicities of Novel Antineoplastic Therapies
Rajha, E., & Yeung, S. J. (2021) · Springer eBooks · doi:10.1007/978-3-030-67123-5_53 · Cited by 1
Wiernik, P. H., Gallagher, R. E., & Tallman, M. S. (2017) · Springer eBooks · doi:10.1007/978-3-319-64263-5_21 · Cited by 1
Care of the Oncology Patient in the PICU
Greiner, R. J., Peterson‐Carmichael, S. L., Rothman, J., Gow, K. W., Tamburro, R. F., & Barfield, R. C. (2014) · Springer eBooks · doi:10.1007/978-1-4471-6416-6_24
Late-onset differentiation syndrome in a child with acute promyelocytic leukemia
Yoshida, H., Matsumura, R., Sato, E., Hashii, Y., Ohta, H., & Ozono, K. (2010) · International Journal of Hematology · doi:10.1007/s12185-010-0647-0
Development of retinoic acid syndrome during leukopenia
Sugiyama, K., Usui, N., Dobashi, N., Yano, S., Takei, Y., Takahara, S., Saito, T., & Aiba, K. (2011) · International Cancer Conference Journal · doi:10.1007/s13691-011-0006-x
High-Risk Acute Promyelocytic Leukemia with Early Differentiation Syndrome: A Therapeutic Dilemma
Malato, A., Santoro, A., Felice, R., Magrin, S., Turri, D., Bica, M. G., Salemi, D., & Fabbiano, F. (2011) · Acta Haematologica · doi:10.1159/000333427
A 56-Year-Old Man With Acute Promyelocytic Leukemia and Pulmonary Infiltrates
Weir, D. C., Fung, J. Y., & Braman, S. S. (2014) · CHEST Journal · doi:10.1378/chest.14-0283
Padrón, C. H., Balea, E. D., García, S. M., Veitía, A. F. M., Otero, A. R. G., Cano, L. M. I., Estrada, E. E., Pita, A. M. S., Vigil, A. M. A., & Ramírez, P. H. (2014) · Revista cubana de hematología, inmunología y hemoterapia
Supportive Care in the Management of Leukaemia
Gil, E., Gant, V. A., & Kottaridis, P. D. (2015) · doi:10.1002/9781118853771.ch23
Organ Toxicity of Cancer Chemotherapy
Seguin, A., Lemiale, V., Moreau, A., Darmon, M., Max, A., Karlin, L., & Azoulay, É. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4377-1367-1.00156-7
First-Line Therapy for APL: Chemotherapy-Based Approach
Goldberg, A. D., & Tallman, M. S. (2018) · Springer eBooks · doi:10.1007/978-3-319-64257-4_8
Management of Treatment-Related Complications in APL
Annibali, O., & Avvisati, G. (2017) · Springer eBooks · doi:10.1007/978-3-319-64257-4_21
(2018) · International Journal of Case Reports · doi:10.28933/ijcr-2018-11-2505
Differentiation (Retinoic Acid) Syndrome in Critically Ill Cancer Patients
Amêndola, C. P., Ciorlia, G. L., Sanches, L. C., & Sales, R. A. S. (2019) · Springer eBooks · doi:10.1007/978-3-319-74698-2_50-1
Therapy-Induced Marrow Changes
Bhargava, P., & Whitman, J. D. (2020) · Springer eBooks · doi:10.1007/978-3-030-32189-5_32
SOHO State of the Art Updates and Next Questions: IDH Inhibition
Dragani, M., & de Botton, S. (2021) · Clinical Lymphoma Myeloma & Leukemia · doi:10.1016/j.clml.2021.05.004
Gurnari, C., Divona, M., & Voso, M. T. (2021) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2021.2006182
Suwal, B., Poudyal, B. S., & Adhikary, R. (2021) · Nepal Journal of Neuroscience · doi:10.3126/njn.v18i4.39199
(2021) · Wiley eBooks · doi:10.1002/9781119611288.refs
Cao, M., Li, H., Xiao, Y. L., & Cai, H. R. (2021) · Journal of Clinical Images and Medical Case Reports · doi:10.52768/2766-7820/1484
(2011) · Wiley eBooks · doi:10.1002/9781444398069.ch1
Hoseinzadeh, G., Mohammadzadeh, Z., Chahardouli, B., Moghaddam, K. A., Mousavi, S. A., Omidkhoda, A., & Rostami, S. (2022) · Molecular Biology Reports · doi:10.1007/s11033-022-07386-1
Differentiation (Retinoic Acid) Syndrome in Critically Ill Cancer Patients
Amêndola, C. P., Guedes, R. A. S. P., & Sanches, L. C. (2019) · Springer eBooks · doi:10.1007/978-3-319-74588-6_50
Recent Publications on Medications and Pharmacy
Sterling, J. A. (2009) · Hospital Pharmacy · doi:10.1310/hpj4404-354
Faucher, M., & Mokart, D. (2010) · Springer eBooks · doi:10.1007/978-2-287-99070-0_22
Chen, S., Yan, X., Zhou, G., & Zhu, C. H. (2022) · Wiley eBooks · doi:10.1002/9781119000822.hfcm011.pub2
Yeung, S. J., & Escalante, C. P. (2022) · Holland‐Frei Cancer Medicine · doi:10.1002/9781119000822.hfcm141.pub2
Acute promyelocytic leukaemia: A central South African experience
Naicker, W., Kloppers, J. F., van Rooyen, C., van Marle, A., & Barrett, C. L. (2022) · South African Journal of Oncology · doi:10.4102/sajo.v6i0.245
Norsworthy, K. J., Mulkey, F. A., Scott, E., Ward, A. F., Przepiorka, D., Charlab, R., Dorff, S. E., Deisseroth, A., Kazandjian, D. G., Sridhara, R., et al. (2023) · doi:10.1158/1078-0432.22476195
Norsworthy, K. J., Mulkey, F. A., Scott, E., Ward, A. F., Przepiorka, D., Charlab, R., Dorff, S. E., Deisseroth, A., Kazandjian, D. G., Sridhara, R., et al. (2023) · doi:10.1158/1078-0432.22476195.v1
Frontline Management of Acute Promyelocytic Leukemia
Gill, H. (2023) · Springer eBooks · doi:10.1007/978-981-99-3810-0_17
Ahmad, K., Saleh, M., Ali, Y., Yaseen, A., Ali, M., Kakakhel, M., & Hayat, M. A. (2023) · Cureus · doi:10.7759/cureus.50042
Childhood Acute Promyelocytic Leukemia
Alodan, K., & Abla, O. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-15717-2.00041-x
Differentiating Acute Myeloid Leukemia Stem Cells/Blasts
Schembri-Wismayer, P., Gatt, L., & Cassar, A. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-15717-2.00014-7
Parry‐Jones, N., Parry-Jones, J., & Wise, M. P. (2023) · doi:10.1093/med/9780198766438.003.0048
Semenova, A. A., Galtseva, I. V., Troitskaya, V. V., Михайлович, К. Н., Davydova, Y. O., Никифорова, К. А., Loseva, A. G., Ermolaev, A., Surimova, V., Kulikov, S. M., et al. (2024) · Oncohematology · doi:10.17650/1818-8346-2024-19-2-56-66
Dutta, M., Das, T., Bora, M., Medhi, P. K., Choudhury, D., Kakoti, S., Hazarika, T., Goswami, H., Bordoloi, Z., & Choudhury, S. (2024) · Apollo Medicine · doi:10.1177/09760016241239702
Survival analysis of acute promyelocytic leukemia in a third-level hospital in Ecuador
Orquera, A., Salazar, S. L., Mendieta-Carrión, L., Salazar, D. G., Jara, J. C., Velasco-Maldonado, P., & Lozada, A. R. (2024) · doi:10.36015/cambios.v23.n2.2024.910
Acute Chemotherapy Administration and Complications
Zhang, L., & Rivero, G. (2024) · Springer eBooks · doi:10.1007/978-3-031-75810-2_5
Acute Differentiation Syndrome
Mudra, S. E., & Williams, L. S. (2024) · Springer eBooks · doi:10.1007/978-3-031-75810-2_6
Lim, Y. J. (2024) · Archives of Pediatric Critical Care · doi:10.32990/apcc.2024.00143
An Untimely Occurrence of Differentiation Syndrome in APL- Better be Suspicious
Nayak, A. R., Aggarwal, M., Naranje, P., Dass, J., & Kumar, P. (2025) · Indian Journal of Hematology and Blood Transfusion · doi:10.1007/s12288-025-01985-1
VI. Diagnosis and Treatment of Acute Promyelocytic Leukemia
Yokoyama, Y. (2024) · Nihon Naika Gakkai Zasshi · doi:10.2169/naika.113.1255
Roshan, R., Shah, M., Sherook, J., Parry, A. F., & Bhat, J. R. (2025) · Cureus · doi:10.7759/cureus.89081
Seçilmiş, S., Candır, B. A., Bozan, E., Yaman, S., Ulu, B. U., Yiğenoğlu, T. N., İskender, D., & Çakar, M. K. (2025) · Acta haematologica oncologica Turcica. · doi:10.4274/ahot.galenos.2025.2025-6-1
Recent Publications on Medications and Pharmacy
Sterling, J. A. (2008) · Hospital Pharmacy · doi:10.1310/hpj4312-1024
Nematollahi, S., Acharya, U. H., & Krishnadasan, R. (2015) · American Journal of Hematology / Oncology®
Wen, J., Xu, F., Zhou, Q., Shi, L., Liu, Y., Yue, J., Zhang, Y., & Liang, X. (2024) · Figshare · doi:10.6084/m9.figshare.26559902
Brotman, I., Lee, C., Vaz, J. A., & Peiris, N. (2025) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9798898813727125010013
High-Throughput Proteomic Profiling to Evaluate Differentiation Syndrome With Menin Inhibition
Garcia, M. B., Wang, B., Sheikh, I. N., Hajjar, G. E., McCall, D. C., Núnêz, C., Gibson, A., Lorenzi, P. L., Issa, G. C., Cuglievan, B., et al. (2026) · Molecular & Cellular Proteomics · doi:10.1016/j.mcpro.2026.101522
Zhou, D.-M., He, J., Zhou, M., Zhang, Q., Chen, L.-X., Yuan, C.-Y., Zeng, H., & Chen, B. (2026) · Frontiers in Medicine · doi:10.3389/fmed.2026.1671705
Wei, H., Zhang, Z., Liu, X., Zhou, Q., Zhang, X., Dong, Y., Zhai, S., Zhang, Q., & Sui, M. (2026) · Discover Oncology · doi:10.1007/s12672-026-05155-1
What the Intensivist Needs to Know About Leukemia Patients
Marvin‐Peek, J., Swaminathan, M., Naqvi, K., & Abbas, H. A. (2026) · Springer eBooks · doi:10.1007/978-3-319-74698-2_96-2
Lou, H., Xu, H., Zhang, H., Xia, J., Qi, Y., Ma, Y. N., Zhang, H., Li, H., Liu, Q. Y., Qi, K., et al. (2026) · Chinese Medical Journal · doi:10.1097/cm9.0000000000004104
Identification and Management of Differentiation Syndrome in Emergency Settings: A Narrative Review
Chang, G. A., Bey, T. A., Stroh, J., Qdaisat, A. Z., & Yeung, S. J. (2026) · Cancers · doi:10.3390/cancers18111798
Gao, M., Ouyang, G., Liu, Y., & Chen, S. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1933105
Zhang, T. Y., Patel, S. A., & Badar, T. (2026) · Cancers · doi:10.3390/cancers18172751
Advances in differentiation syndrome in acute promyelocytic leukemia: From mechanisms to management
Han, S., Zhao, Y., Su, Y., 王迎新, Wang, D., & Xing, X. (2026) · Blood Reviews · doi:10.1016/j.blre.2026.101419
DNV-TC: a developmental network vulnerability-based classification system for precision oncology
Toncheva, D., & Sgurev, V. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2026.1780827
Ji, J., Zhu, Y., Luo, D., Ding, P., Li, H., Zhao, Y., Guo, Z., Li, Q., Liu, J., Guo, D., et al. (2026) · Frontiers in Oncology · doi:10.3389/fonc.2026.1961271
Xu, J., Bai, H., & Hu, L. (2026) · MedComm – Future Medicine · doi:10.1002/mef2.70070
Bufka, J., Vaňková, L., Sýkora, J., Schwarz, J., & Křížková, V. (2026) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2026.105086
Metadata
- Authors
- Montesinos, P., Bergua, J. M., Vellenga, E., Rayón, C., Parody, R., de la Serna, J., León, A., Esteve, J., Milone, G., Debén, G., Rivas, C., González, M., Tormo, M., Díaz-Mediavilla, J., González, J. D., Negri, S., Amutio, E., Brunet, S., Lowenberg, B., & Sanz, M. A.
- Affiliations
- Universitat Autònoma de Barcelona (ES)
- Hospital San Pedro de Alcántara (ES)
- University Medical Center Groningen (NL)
- Hospital Universitario Central de Asturias (ES)
- Hospital Universitario Virgen del Rocío (ES)
- Hospital 12 de Octubre, Madrid, Spain;
- Hospital General, Jerez de la Frontera, Spain;
- Hospital Clínic de Barcelona (ES)
- Fundaleu, Buenos Aires, Argentina;
- Hospital Juan Canalejo, La Coruña, Spain;
- Hospital General Universitario de Alicante Doctor Balmis (ES)
- Hospital Universitario, Salamanca, Spain;
- Hospital Clínico Universitario de Valencia (ES)
- Hospital Clínico San Carlos, Madrid, Spain;
- Hospital Insular, Las Palmas, Spain;
- Hospital Carlos Haya, Málaga, Spain;
- Hospital de Cruces (ES)
- Hospital de Sant Pau (ES)
- Erasmus University Medical Center, Rotterdam, The Netherlands
- Hospital Universitario La Fe, Valencia, Spain;
- ORCID
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2009-01-22
- Volume
- 113
- Issue
- 4
- Pages
- 775-783
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W1982745688
- Cited by
- 362
- References
- 42
- Citations by year
- 2026: 19 · 2025: 22 · 2024: 31 · 2023: 23 · 2022: 21 · 2021: 33 · 2020: 33 · 2019: 22 · 2018: 23 · 2017: 19 · 2016: 16 · 2015: 15 · 2014: 17 · 2013: 8 · 2012: 11
- FWCI
- 6.58
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Blood (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion, other-oa)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion, other-oa)
- RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinoids in leukemia and cellular processes
- Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
- Health Sciences › Medicine › Hematology › Acute Lymphoblastic Leukemia research
- Keywords
- differentiation syndrome, acute promyelocytic leukemia, all-trans retinoic acid, idarubicin, anthracycline chemotherapy, prognostic factors, mortality, relapse-free survival, dexamethasone prophylaxis, serum creatinine, white blood cell count
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Child, Child, Preschool, Drug Therapy, Combination, Female, Humans, Male, Middle Aged, Prognosis, Recurrence, Risk Factors, Syndrome, Time Factors, Tretinoin, Leukemia, Promyelocytic, Acute, Disease-Free Survival, Anthracyclines
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
