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Cited by 395Immunotherapy and Immune ResponsesT-cell and B-cell ImmunologyImmune Response and Inflammation

Dendritic cell homeostasis

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Merad, Miriam, Manz, Markus G.·2009·Blood
DOI 10.1182/blood-2008-12-180646PMC PMC2668851
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Abstract

Dendritic cells (DCs) are a heterogeneous fraction of rare hematopoietic cells that coevolved with the formation of the adaptive immune system. DCs efficiently process and present antigen, move from sites of antigen uptake to sites of cellular interactions, and are critical in the initiation of immune responses as well as in the maintenance of self-tolerance. DCs are distributed throughout the body and are enriched in lymphoid organs and environmental contact sites. Steady-state DC half-lives account for days to up to a few weeks, and they need to be replaced via proliferating hematopoietic progenitors, monocytes, or tissue resident cells. In this review, we integrate recent knowledge on DC progenitors, cytokines, and transcription factor usage to an emerging concept of in vivo DC homeostasis in steady-state and inflammatory conditions. We furthermore highlight how knowledge of these maintenance mechanisms might impact on understanding of DC malignancies as well as posttransplant immune reactions and their respective therapies.

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  • STAT3 plays major roles in immature dendritic cell development and function, affecting both plasmacytoid DCs and conventional DCs.

    “STAT3 also plays major roles in immature DC development and function”

    From Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 To Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution (2020) · cites this paper as Merad and Manz, 2009

    The ‘Transcription factors in DC development’ section reports that STAT3 affects Flt3L-mediated development of both plasmacytoid DCs and other DCs. It does not establish a role in immature DC function, and it specifies that STAT3 deficiency does not block GM-CSF-mediated DC development. (LLM, conf=0.85)

    Experimental — accuracy not yet measured

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References 126 · Cited by 395

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Authors
Merad, M., & Manz, M. G.
Affiliations
  • Department of Gene and Cell Medicine and Department of Medicine, Mount Sinai School of Medicine, New York, NY;
  • Institute for Research in Biomedicine (CH)
ORCID
Manz, Markus G.
Venue
Blood
Publisher
American Society of Hematology
Published
2009-04-09
Volume
113
Issue
15
Pages
3418-3427
ISSN
  • 0006-4971 (ISSN-L)
  • 1528-0020
DOI
10.1182/blood-2008-12-180646
PMC
PMC2668851
OpenAlex
W1988136067
Cited by
395
References
126
Citations by year
2026: 3 · 2025: 6 · 2024: 5 · 2023: 10 · 2022: 12 · 2021: 10 · 2020: 17 · 2019: 13 · 2018: 16 · 2017: 13 · 2016: 20 · 2015: 25 · 2014: 23 · 2013: 46 · 2012: 47
FWCI
4.59
Type
journal article
Language
en
Open access
Locations
  • Blood (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, other-oa)
  • Zurich Open Repository and Archive (University of Zurich) (submittedVersion, other-oa)
  • Zurich Open Repository and Archive (University of Zurich)
Funders
  • National Science Foundation
  • European Commission
  • Deutsche Forschungsgemeinschaft (2159/2)
  • Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (116637, 310000)
  • National Institutes of Health
  • National Cancer Institute (R01CA1121100)
  • National Institute of Allergy and Infectious Diseases (R01AI0086899)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords
dendritic cells, dendritic cell homeostasis, dendritic cell progenitors, monocytes, cytokines, transcription factors, inflammatory diseases, antigen presentation, self-tolerance
MeSH terms
Dendritic Cells, Homeostasis, Humans, Transplantation Immunology

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