The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Two distinct pathways regulate platelet phosphatidylserine exposure and procoagulant function
Abstract
Procoagulant platelets exhibit hallmark features of apoptotic cells, including membrane blebbing, microvesiculation, and phosphatidylserine (PS) exposure. Although platelets possess many well-known apoptotic regulators, their role in regulating the procoagulant function of platelets is unclear. To clarify this, we investigated the consequence of removing the essential mediators of apoptosis, Bak and Bax, or directly inducing apoptosis with the BH3 mimetic compound ABT-737. Treatment of platelets with ABT-737 triggered PS exposure and a marked increase in thrombin generation in vitro. This increase in procoagulant function was Bak/Bax- and caspase-dependent, but it was unaffected by inhibitors of platelet activation or by chelating extracellular calcium. In contrast, agonist-induced platelet procoagulant function was unchanged in Bak−/−Bax−/− or caspase inhibitor–treated platelets, but it was completely eliminated by extracellular calcium chelators or inhibitors of platelet activation. These studies show the existence of 2 distinct pathways regulating the procoagulant function of platelets.
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Cites
Programmed Anuclear Cell Death Delimits Platelet Life Span
Mason, K. D., Carpinelli, M. R., Fletcher, J. I., Collinge, J. E., Hilton, A. A., Ellis, S., Kelly, P. N., Ekert, P. G., Metcalf, D., Roberts, A. W., et al. (2007) · Cell · doi:10.1016/j.cell.2007.01.037 · Cited by 1,031
Self-citation
Cited by
Calcium-dependent Phospholipid Scramblase Activity of TMEM16 Protein Family Members
Suzuki, J., Fujii, T., Imao, T., Ishihara, K., Kuba, H., & Nagata, S. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.457937 · Cited by 371
Schoenwaelder, S. M., Jarman, K. E., Gardiner, E. E., Hua, M., Qiao, J., White, M. J., Josefsson, E. C., Alwis, I., Ono, A., Willcox, A., et al. (2011) · Blood · doi:10.1182/blood-2011-04-347849 · Cited by 351
Self-citationThe role of apoptosis in megakaryocytes and platelets
Kile, B. T. (2014) · British Journal of Haematology · doi:10.1111/bjh.12757 · Cited by 122
Self-citationBCL-2 is dispensable for thrombopoiesis and platelet survival
Debrincat, M. A., Pleines, I., Lebois, M., Lane, R. M., Holmes, M. L., Corbin, J., Vandenberg, C. J., Alexander, W. S., Ng, A. P., Strasser, A., et al. (2015) · Cell Death & Disease · doi:10.1038/cddis.2015.97 · Cited by 92
Self-citationAfter cell death: the molecular machinery of efferocytosis
Moon, B., Yang, S., Moon, H., Lee, J., & Park, D. (2023) · Experimental & Molecular Medicine · doi:10.1038/s12276-023-01070-5 · Cited by 78
Metadata
- Authors
- Schoenwaelder, S. M., Yuan, Y., Josefsson, E. C., White, M. J., Yao, Y., Mason, K. D., O'Reilly, L. A., Henley, K. J., Ono, A., Hsiao, S., Willcox, A., Roberts, A. W., Huang, D. C. S., Salem, H. H., Kile, B. T., & Jackson, S. P.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2009-07-16
- Volume
- 114
- Issue
- 3
- Pages
- 663-666
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2022645745
- Cited by
- 313
- References
- 1
- FWCI
- 14.66
- Type
- journal article
- Language
- en
- Open access
- closed
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- Schoenwaelder, S. M., Yuan, Y., Josefsson, E. C., White, M. J., Yao, Y., Mason, K. D., O'Reilly, L. A., Henley, K. J., Ono, A., Hsiao, S., Willcox, A., Roberts, A. W., Huang, D. C. S., Salem, H. H., Kile, B. T., & Jackson, S. P. (2009). Two distinct pathways regulate platelet phosphatidylserine exposure and procoagulant function. Blood. https://doi.org/10.1182/blood-2009-01-200345
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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