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Cited by 78Phagocytosis and Immune RegulationCell death mechanisms and regulationAutophagy in Disease and Therapy

After cell death: the molecular machinery of efferocytosis

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Moon, Byeongjin, Yang, Susumin, Moon, Hyunji, Lee, Juyeon, Park, Daeho·2023·Experimental & Molecular Medicine
DOI 10.1038/s12276-023-01070-5PMC PMC10474042
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Abstract

Cells constituting a multicellular organism die in a variety of ways throughout life, and most of them die via apoptosis under normal conditions. The occurrence of apoptosis is especially prevalent during development and in tissues with a high cellular turnover rate, such as the thymus and bone marrow. Interestingly, although the number of apoptotic cells produced daily is known to be innumerable in a healthy adult human body, apoptotic cells are rarely observed. This absence is due to the existence of a cellular process called efferocytosis that efficiently clears apoptotic cells. Studies over the past decades have focused on how phagocytes are able to remove apoptotic cells specifically, swiftly, and continuously, resulting in defined molecular and cellular events. In this review, we will discuss the current understanding of the clearance of apoptotic cells at the molecular level.

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  • Efferocytosis does not culminate in antigen presentation and instead evokes a highly immune suppressive macrophage phenotype.

    “Efferocytosis does not culminate in antigen presentation and instead evokes a highly immune suppressive macrophage phenotype (35, 36).”

    From Cholesterol efflux protein, ABCA1, supports anticancer functions of myeloid immune cells (2026) · cites this paper as [35]

    The Introduction (page unavailable) says engulfment of apoptotic cells generally induces anti-inflammatory responses or is immunologically silent. The Degradation of apoptotic cells section (page unavailable) reports increased production of anti-inflammatory mediators, including IL-10. These passages support an anti-inflammatory response, but do not establish that efferocytosis never culminates in antigen presentation or always produces a highly immunosuppressive macrophage phenotype. (LLM, conf=0.86)

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Cited by

Sorted by citations

Authors
Moon, B., Yang, S., Moon, H., Lee, J., & Park, D.
Affiliations
Gwangju Institute of Science and Technology (KR)
Corresponding author
Park, Daeho
ORCID
Venue
Experimental & Molecular Medicine
Publisher
Springer Science and Business Media LLC
Published
2023-08-23
Volume
55
Issue
8
Pages
1644-1651
ISSN
  • 1226-3613 (ISSN-L)
  • 2092-6413
DOI
10.1038/s12276-023-01070-5
PMC
PMC10474042
OpenAlex
W4386098134
Cited by
78
References
18
Citations by year
2026: 31 · 2025: 33 · 2024: 14
FWCI
2.17
Type
journal article
Language
en
Open access
Licence
Locations
  • Experimental & Molecular Medicine (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
National Research Foundation of Korea (2022R1A2C1008334, 2022R1A4A2000790)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
  • Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
Keywords
efferocytosis, phagocytes, apoptosis, phagocytosis, molecular mechanisms, tissue homeostasis, cell turnover
MeSH terms
Adult, Humans, Kinetics, Phagocytes, Phagocytosis, Cell Death, Apoptosis

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