MAL/SRF complex is involved in platelet formation and megakaryocyte migration by regulating MYL9 (MLC2) and MMP9

In Vivo Gene Delivery and Stable Transduction of Nondividing Cells by a Lentiviral Vector

Naldini, L., Blömer, U., Gallay, P., Ory, D., Mulligan, R., Gage, F. H., Verma, I. M., & Trono, D. (1996) · Science · doi:10.1126/science.272.5259.263 · Cited by 4,903 · see citing works

Rho GTPases in cell biology

Etienne‐Manneville, S., & Hall, A. (2002) · Nature · doi:10.1038/nature01148 · Cited by 4,796 · see citing works

A System for Stable Expression of Short Interfering RNAs in Mammalian Cells

Brummelkamp, T. R., Bernards, R., & Agami, R. (2002) · Science · doi:10.1126/science.1068999 · Cited by 4,295 · see citing works

Actin dynamics control SRF activity by regulation of its coactivator MAL

Miralles, F., Posern, G., Zaromytidou, A.-I., & Treisman, R. (2003) · Cell · doi:10.1016/s0092-8674(03)00278-2 · Cited by 1,327 · see citing works

The Rho family GTPases RhoA, Racl , and CDC42Hsregulate transcriptional activation by SRF

Hill, C. S., Wynne, J., & Treisman, R. (1995) · Cell · doi:10.1016/s0092-8674(05)80020-0 · Cited by 1,269 · see citing works

Activation of Cardiac Gene Expression by Myocardin, a Transcriptional Cofactor for Serum Response Factor

Wang, D.-Z., Chang, P. S., Wang, Z., Sutherland, L. B., Richardson, J. A., Small, E. M., Krieg, P. A., & Olson, E. N. (2001) · Cell · doi:10.1016/s0092-8674(01)00404-4 · Cited by 898 · see citing works

Rho GTPases and the control of cell behaviour

Hall, A. (2005) · Biochemical Society Transactions · doi:10.1042/bst20050891 · Cited by 793 · see citing works

Ternary complex factors: growth factor regulated transcriptional activators

Treisman, R. (1994) · Current Opinion in Genetics & Development · doi:10.1016/0959-437x(94)90097-3 · Cited by 676 · see citing works

Nuclear Actin Regulates Dynamic Subcellular Localization and Activity of the SRF Cofactor MAL

Vartiainen, M., Guettler, S., Larijani, B., & Treisman, R. (2007) · Science · doi:10.1126/science.1141084 · Cited by 672 · see citing works

The biogenesis of platelets from megakaryocyte proplatelets

Patel, S. (2005) · Journal of Clinical Investigation · doi:10.1172/jci26891 · Cited by 604 · see citing works

Blood Platelets Are Assembled Principally at the Ends of Proplatelet Processes Produced by Differentiated Megakaryocytes

Italiano, J. E., Lécine, P., Shivdasani, R. A., & Hartwig, J. H. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.6.1299 · Cited by 561 · see citing works

The myocardin family of transcriptional coactivators: versatile regulators of cell growth, migration, and myogenesisPreprint

Pipes, G. C. T., Creemers, E. E., & Olson, E. N. (2006) · Genes & Development · doi:10.1101/gad.1428006 · Cited by 475 · see citing works

Thrombospondin-1 is required for normal murine pulmonary homeostasis and its absence causes pneumonia.

Lawler, J., Sunday, M. E., Thibert, V., Duquette, M. A., George, E. L., Rayburn, H., & Hynes, R. O. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1684 · Cited by 456 · see citing works

Myocardin-related transcription factors and SRF are required for cytoskeletal dynamics and experimental metastasis

Medjkane, S., Pérez-Sánchez, C., Gaggioli, C., Sahai, E. A., & Treisman, R. (2009) · Nature Cell Biology · doi:10.1038/ncb1833 · Cited by 407 · see citing works

Platelets generated in vitro from proplatelet-displaying human megakaryocytes are functional

Choi, E., Nichol, J. L., Hokom, M., Hornkohl, A. C., & Hunt, P. (1995) · Blood · doi:10.1182/blood.v85.2.402.402 · Cited by 374 · see citing works

Serum response factor is essential for mesoderm formation during mouse embryogenesis

Arsenian, S., Weinhold, B., Oelgeschläger, M., Rüther, U., & Nordheim, A. (1998) · The EMBO Journal · doi:10.1093/emboj/17.21.6289 · Cited by 373 · see citing works

Signal transduction and the Ets family of transcription factors

Yordy, J. S., & Muise‐Helmericks, R. C. (2000) · Oncogene · doi:10.1038/sj.onc.1204036 · Cited by 325 · see citing works

Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia

Ma, Z., Morris, S. W., Valentine, V. A., Martin, L., Herbrick, J.-A., Cui, X., Bouman, D., Li, Y., Mehta, P. K., Nižetić, D., et al. (2001) · Nature Genetics · doi:10.1038/90054 · Cited by 304 · see citing works

Megakaryoblastic Leukemia 1, a Potent Transcriptional Coactivator for Serum Response Factor (SRF), Is Required for Serum Induction of SRF Target Genes

Cen, B., Selvaraj, A., Burgess, R. C., Hitzler, J. K., Ma, Z., Morris, S. W., & Prywes, R. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.18.6597-6608.2003 · Cited by 289 · see citing works

Lentiviral-Mediated RNA Interference

Abbas‐Terki, T., Blanco-Bose, W. E., Déglon, N., Pralong, W. F., & Aebischer, P. (2002) · Human Gene Therapy · doi:10.1089/104303402320987888 · Cited by 284 · see citing works

The SRE: a growth factor responsive transcriptional regulator.

Treisman, R. (1990) · PubMed · Cited by 277 · see citing works

Dual roles of myocardin-related transcription factors in epithelial–mesenchymal transition via <i>slug</i> induction and actin remodeling

Morita, T., Mayanagi, T., & Sobue, K. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200708174 · Cited by 262 · see citing works

Transendothelial Migration of Megakaryocytes in Response to Stromal Cell-derived Factor 1 (SDF-1) Enhances Platelet Formation

Hamada, T., Möhle, R., Hesselgesser, J., Hoxie, J. A., Nachman, R. L., Moore, M. A. S., & Rafii, S. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.3.539 · Cited by 243 · see citing works

Involvement of a human gene related to the Drosophila spen gene in the recurrent t(1;22) translocation of acute megakaryocytic leukemia

Mercher, T., Coniat, M. L., Monni, R., Mauchauffé, M., Nguyen‐Khac, F., Gressin, L., Mugneret, F., Leblanc, T. M., Dastugue, N., Berger, R., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.101001498 · Cited by 233 · see citing works

The c-Mpl Ligand (Thrombopoietin) Stimulates Tyrosine Phosphorylation of Jak2, Shc, and c-Mpl

Drachman, J. G., Griffin, J. D., & Kaushansky, K. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.10.4979 · Cited by 223 · see citing works

Characterization of the megakaryocyte demarcation membrane system and its role in thrombopoiesis

Schulze, H., Korpal, M., Hurov, J., Kim, S.-W., Zhang, J., Cantley, L. C., Graf, T., & Shivdasani, R. A. (2006) · Blood · doi:10.1182/blood-2005-07-2755 · Cited by 211 · see citing works

Apoptosis regulation in tetraploid cancer cells

Castedo, M., Coquelle, A., Vivet, S., Vitale, I., Kauffmann, A., Dessen, P., Péquignot, M. O., Casares, N., Valent, A., Mouhamad, S., et al. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601127 · Cited by 206 · see citing works

Effects of the recombinant hematopoietic growth factors interleukin-3, interleukin-6, stem cell factor, and leukemia inhibitory factor on the megakaryocytic differentiation of CD34+ cells

Debili, N., Massé, J., Katz, A., Guichard, J., Breton-Gorius, J., & Vainchenker, W. (1993) · Blood · doi:10.1182/blood.v82.1.84.bloodjournal82184 · Cited by 206 · see citing works

Megakaryocyte endomitosis is a failure of late cytokinesis related to defects in the contractile ring and Rho/Rock signaling

Lordier, L., Jalil, A., Aurade, F., Larbret, F., Larghero, J., Debili, N., Vainchenker, W., & Chang, Y. (2008) · Blood · doi:10.1182/blood-2008-03-144956 · Cited by 203 · see citing works

Requirement of a Myocardin-Related Transcription Factor for Development of Mammary Myoepithelial Cells

Li, S., Chang, S.-R., Qi, X.-X., Richardson, J., & Olson, E. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00211-06 · Cited by 200 · see citing works

Serum response factor is crucial for actin cytoskeletal organization and focal adhesion assembly in embryonic stem cells

Schratt, G. M., Philippar, U., Berger, J., Schwarz, H., Heidenreich, O. T., & Nordheim, A. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200106008 · Cited by 197 · see citing works

Ultrastructure of Platelet Formation by Human Megakaryocytes Cultured With the Mpl Ligand

Cramer, E. M., Norol, F., Guichard, J., BRETON-GORIUS, J., Vainchenker, W., Massé, J., & Debili, N. (1997) · Blood · doi:10.1182/blood.v89.7.2336 · Cited by 186 · see citing works

Molecular and Transcriptional Regulation of Megakaryocyte Differentiation

Shivdasani, R. A. (2001) · Stem Cells · doi:10.1634/stemcells.19-5-397 · Cited by 180 · see citing works

Proplatelet formation is regulated by the Rho/ROCK pathway

Chang, Y., Aurade, F., Larbret, F., Zhang, Y., Couedic, J. P. L., Momeux, L., Larghero, J., Bertoglio, J. H., Louache, F., Cramer, E. M., et al. (2007) · Blood · doi:10.1182/blood-2006-04-020024 · Cited by 176 · see citing works

Serum response factor: discovery, biochemistry, biological roles and implications for tissue injury healing.

Chai, J., & Tarnawski, A. S. (2002) · PubMed · Cited by 175 · see citing works

The May-Hegglin anomaly gene MYH9 is a negative regulator of platelet biogenesis modulated by the Rho-ROCK pathway

Chen, Z., Naveiras, O., Balduini, A., Mammoto, A., Conti, M. A., Adelstein, R. S., Ingber, D. E., Daley, G. Q., & Shivdasani, R. A. (2007) · Blood · doi:10.1182/blood-2007-02-071589 · Cited by 173 · see citing works

The t(1;22) (p13;q13) is nonrandom and restricted to infants with acute megakaryoblastic leukemia: a Pediatric Oncology Group Study

Carroll, A. J., Civin, C., Schneider, N. R., Dahl, G. V. H., Pappo, A. S., Bowman, P., Emami, A., Gross, S. A., Alvarado, C., & Phillips, C. (1991) · Blood · doi:10.1182/blood.v78.3.748.748 · Cited by 171 · see citing works

Blood platelet formation in vitro. The role of the cytoskeleton in megakaryocyte fragmentation

Tablin, F., Castro, M. D., & Leven, R. M. (1990) · Journal of Cell Science · doi:10.1242/jcs.97.1.59 · Cited by 166 · see citing works

Expression profiling of serum inducible genes identifies a subset of SRF target genes that are MKL dependent

Selvaraj, A., & Prywes, R. (2004) · BMC Molecular Biology · doi:10.1186/1471-2199-5-13 · Cited by 165 · see citing works

Stromal-derived factor 1–induced megakaryocyte migration and platelet production is dependent on matrix metalloproteinases

Lane, W. J., Dias, S., Hattori, K., Heissig, B., Choy, M., Rabbany, S. Y., Wood, J. M., Moore, M. A. S., & Rafii, S. (2000) · Blood · doi:10.1182/blood.v96.13.4152 · Cited by 162 · see citing works

From hematopoietic stem cells to platelets

Chang, Y., Bluteau, D., Debili, N., & Vainchenker, W. (2007) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2007.02472.x · Cited by 149 · see citing works

Megakaryoblastic Leukemia-1/2, a Transcriptional Co-activator of Serum Response Factor, Is Required for Skeletal Myogenic Differentiation

Selvaraj, A., & Prywes, R. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305679200 · Cited by 134 · see citing works

Role of metalloproteinases in platelet function

Santos-Martínez, M. J., Medina, C., Jurasz, P., & Radomski, M. W. (2007) · Thrombosis Research · doi:10.1016/j.thromres.2007.06.002 · Cited by 130 · see citing works

Abnormal megakaryocyte morphology and proplatelet formation in mice with megakaryocyte-restricted MYH9 inactivation

Eckly, A. E., Strassel, C., Freund, M., Cazenave, J., Lanza, F., Gachet, C., & Léon, C. (2008) · Blood · doi:10.1182/blood-2008-06-164061 · Cited by 122 · see citing works

Phenotypic and Functional Evidence for the Expression of CXCR4 Receptor During Megakaryocytopoiesis

Rivière, C., Subra, F., Cohen-Solal, K., Cordette-Lagarde, V., Letestu, R., Auclair, C., Vainchenker, W., & Louache, F. (1999) · Blood · doi:10.1182/blood.v93.5.1511 · Cited by 122 · see citing works

Nineteen cases of the t(1;22)(p13;q13) acute megakaryblastic leukaemia of infants/children and a review of 39 cases: report from a t(1;22) study group

Bernstein, J., Dastugue, N., Haas, O., Harbott, J., Heere, N., Huret, J. L., Landman‐Parker, J., Beau, M. M. L., Leonard, C. A., Mann, G., et al. (2000) · Leukemia · doi:10.1038/sj.leu.2401639 · Cited by 121 · see citing works

The translocation t(1;22)(p13;q13) is a nonrandom marker specifically associated with acute megakaryocytic leukemia in young children

Lion, T., Haas, O., Harbott, J., Bannier, E., Ritterbach, J., Jankovic, M., Fink, F. M., Stojimirovic, A., Herrmann, J., & Riehm, H. (1992) · Blood · doi:10.1182/blood.v79.12.3325.3325 · Cited by 114 · see citing works

Inherited thrombocytopenias: from genes to therapy.

Balduini, C. L., Iolascon, A., & Savoia, A. (2002) · PubMed · Cited by 112 · see citing works

The OTT-MAL fusion oncogene activates RBPJ-mediated transcription and induces acute megakaryoblastic leukemia in a knockin mouse model

Mercher, T., Raffel, G. D., Moore, S. A., Cornejo, M., Bluteau, D., Cagnard, N., Jesneck, J. L., Pikman, Y., Cullen, D. E., Williams, I. R., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci35901 · Cited by 111 · see citing works

Differential regulation of actin stress fiber assembly and proplatelet formation by α2β1 integrin and GPVI in human megakaryocytes

Sabri, S., Jandrot‐Perrus, M., Bertoglio, J. H., Farndale, R. W., Mas, V. M., Debili, N., & Vainchenker, W. (2004) · Blood · doi:10.1182/blood-2003-12-4398 · Cited by 109 · see citing works

The Thrombocytopenia of Wiskott Aldrich Syndrome Is Not Related to a Defect in Proplatelet Formation

Haddad, É., Cramer, E. M., Rivière, C., Rameau, P., Louache, F., Guichard, J., Nelson, D. L., Fischer, A., Vainchenker, W., & Debili, N. (1999) · Blood · doi:10.1182/blood.v94.2.509 · Cited by 94 · see citing works

Roles of focal adhesion kinase (FAK) in megakaryopoiesis and platelet function: studies using a megakaryocyte lineage–specific FAK knockout

Hitchcock, I. S., Fox, N. E., Prévost, N., Sear, K., Shattil, S. J., & Kaushansky, K. (2007) · Blood · doi:10.1182/blood-2007-05-089680 · Cited by 88 · see citing works

Role for MKL1 in megakaryocytic maturation

Cheng, E.-C., Luo, Q., Bruscia, E. M., Renda, M. J., Troy, J. A., Massaro, S. A., Tuck, D. P., Schulz, V., Mane, S., Berliner, N., et al. (2009) · Blood · doi:10.1182/blood-2008-09-180596 · Cited by 87 · see citing works

Actin reorganization and proplatelet formation in murine megakaryocytes: the role of protein kinase Cα

Rojnuckarin, P., & Kaushansky, K. (2001) · Blood · doi:10.1182/blood.v97.1.154 · Cited by 87 · see citing works

Identification of a Novel Transcriptional Activator, BSAC, by a Functional Cloning to Inhibit Tumor Necrosis Factor-induced Cell Death

Sasazuki, T., Sawada, T., Komazawa‐Sakon, S., Kitamura, T., Kishi, T., Okazaki, T., Katano, M., Tanaka, M., Watanabe, M., Yagita∥, H., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m203190200 · Cited by 86 · see citing works

Role of p21Cip1/Waf1 in cell-cycle exit of endomitotic megakaryocytes

Baccini, V., Roy, L., Vitrat, N., Chagraoui, H., Sabri, S., Couedic, J. P. L., Debili, N., Wendling, F., & Vainchenker, W. (2001) · Blood · doi:10.1182/blood.v98.12.3274 · Cited by 77 · see citing works

Reorganization of the actin cytoskeleton via transcriptional regulation of cytoskeletal/focal adhesion genes by myocardin-related transcription factors (MRTFs/MAL/MKLs)

Morita, T., Mayanagi, T., & Sobue, K. (2007) · Experimental Cell Research · doi:10.1016/j.yexcr.2007.07.008 · Cited by 74 · see citing works

P19INK4D links endomitotic arrest and megakaryocyte maturation and is regulated by AML-1

Gilles, L., Guièze, R., Bluteau, D., Cordette-Lagarde, V., Lacout, C., Favier, R., Larbret, F., Debili, N., Vainchenker, W., & Raslová, H. (2008) · Blood · doi:10.1182/blood-2007-09-113266 · Cited by 58 · see citing works

Thrombopoietin Induces Tyrosine Phosphorylation and Activation of Mitogen-Activated Protein Kinases in a Human Thrombopoietin-Dependent Cell Line

Yamada, M., Komatsu, N., Okada, K., Kato, T., Miyazaki, H., & Miura, Y. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.2768 · Cited by 56 · see citing works

OTT-MAL Is a Deregulated Activator of Serum Response Factor-Dependent Gene Expression

Descot, A., Rex‐Haffner, M., Courtois, G., Bluteau, D., Menssen, A., Mercher, T., Bernard, O., Treisman, R., & Posern, G. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00303-08 · Cited by 41 · see citing works

Functional interactions between phosphatase POPX2 and mDia modulate RhoA pathways

Xie, Y., Tan, E., Wee, S., Manser, E. J., Lim, L., & Koh, C.-G. (2008) · Journal of Cell Science · doi:10.1242/jcs.013557 · Cited by 34 · see citing works

Arachidonic acid, a principal product of Rac‐activated phospholipase A2, stimulates c‐fos serum response element via Rho‐dependent mechanism

Kim, B.-C., Lim, C., & Kim, J. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)01152-6 · Cited by 26 · see citing works

Thrombospondin-1 inhibits in vitro megakaryocytopoiesis via CD36

Yang, M., Li, K., Ng, M. H. L., Yuen, P. M. P., Fok, T. F., Li, C. K., Hogg, P. J., & Chong, B. H. (2003) · Thrombosis Research · doi:10.1016/s0049-3848(03)00142-7 · Cited by 23 · see citing works

Silencing of a Targeted Protein in In Vivo Platelets Using a Lentiviral Vector Delivering Short Hairpin RNA Sequence

Ohmori, T., Kashiwakura, Y., Ishiwata, A., Madoiwa, S., Mimuro, J., & Sakata, Y. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.149872 · Cited by 22 · see citing works

A t(1;22)(p13;q13) in Four Children with Acute Megakaryoblastic Leukemia (M7), Two with Down Syndrome

Arana-Trejo, R. M., Aguilera, R. P., Nieto, S., & Kofman, S. (2000) · Cancer Genetics and Cytogenetics · doi:10.1016/s0165-4608(99)00251-4 · Cited by 17 · see citing works

MicroRNA-200c Represses Migration and Invasion of Breast Cancer Cells by Targeting Actin-Regulatory Proteins FHOD1 and PPM1F

Jurmeister, S., Baumann, M., Balwierz, A., Keklikoglou, I., Ward, A., Uhlmann, S., Zhang, J. D., Wiemann, S., & Şahin, Ö. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.06212-11 · Cited by 228 · see citing works

Inhibition of TET2-mediated conversion of 5-methylcytosine to 5-hydroxymethylcytosine disturbs erythroid and granulomonocytic differentiation of human hematopoietic progenitors

Pronier, E., Almire, C., Mokrani, H., Vasanthakumar, A., Simon, A., Monte-Mór, B. D. C. R., Massé, A., Couedic, J. P. L., Pendino, F., Carbonne, B., et al. (2011) · Blood · doi:10.1182/blood-2010-12-324707 · Cited by 184 · see citing works

The biology of pediatric acute megakaryoblastic leukemia

Gruber, T. A., & Downing, J. R. (2015) · Blood · doi:10.1182/blood-2015-05-567859 · Cited by 154 · see citing works

Identification of Regulators of Polyploidization Presents Therapeutic Targets for Treatment of AMKL

Wen, Q. J., Goldenson, B., Silver, S. J., Schenone, M., Dančík, V., Huang, Z., Wang, L.-Z., Lewis, T. A., An, W. F., Li, X., et al. (2012) · Cell · doi:10.1016/j.cell.2012.06.032 · Cited by 155 · see citing works

Megakaryocyte and polyploidization

Mazzi, S., Lordier, L., Debili, N., Raslová, H., & Vainchenker, W. (2017) · Experimental Hematology · doi:10.1016/j.exphem.2017.10.001 · Cited by 141 · see citing works

Myocardin-Related Transcription Factor A Epigenetically Regulates Renal Fibrosis in Diabetic Nephropathy

Xu, H., Wu, X., Qin, H., Tian, W., Chen, J., Sun, L., Fang, M., & Xu, Y. (2014) · Journal of the American Society of Nephrology · doi:10.1681/asn.2014070678 · Cited by 127 · see citing works

Dysmegakaryopoiesis of FPD/AML pedigrees with constitutional RUNX1 mutations is linked to myosin II deregulated expression

Bluteau, D., Glembotsky, A. C., Raimbault, A., Balayn, N., Gilles, L., Rameau, P., Nurden, P., Alessi, M., Debili, N., Vainchenker, W., et al. (2012) · Blood · doi:10.1182/blood-2012-04-422337 · Cited by 117 · see citing works

Immunodeficiency and severe susceptibility to bacterial infection associated with a loss-of-function homozygous mutation of MKL1

Record, J., Malinova, D., Zenner, H. L., Plagnol, V., Nowak, K., Syed, F., Bouma, G., Curtis, J. W., Gilmour, K. C., Cale, C. M., et al. (2015) · Blood · doi:10.1182/blood-2014-12-611012 · Cited by 89 · see citing works

Six Novel Loci Associated with Circulating VEGF Levels Identified by a Meta-analysis of Genome-Wide Association Studies

Choi, S. H., Ruggiero, D., Sorice, R., Song, C., Nutile, T., Smith, A. V., Concas, M. P., Traglia, M., Barbieri, C., Ndiaye, N. C., et al. (2016) · PLoS Genetics · doi:10.1371/journal.pgen.1005874 · Cited by 83 · see citing works

Brain-derived neurotrophic factor induces matrix metalloproteinase 9 expression in neurons via the serum response factor/c-Fos pathway

Kuzniewska, B., Rejmak, E., Malik, A. R., Jaworski, J., Kaczmarek, L., & Kalita, K. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.00008-13 · Cited by 82 · see citing works

MRTF-A mediates LPS-induced pro-inflammatory transcription by interacting with the COMPASS complex

Yu, L., Weng, X., Liang, P., Dai, X., Wu, X.-Y., Xu, H., Fang, M., Fang, F., & Xu, Y. (2014) · Journal of Cell Science · doi:10.1242/jcs.152314 · Cited by 81 · see citing works

Importance of environmental stiffness for megakaryocyte differentiation and proplatelet formation

Aguilar, A., Pertuy, F., Eckly, A. E., Strassel, C., Collin, D., Gachet, C., Lanza, F., & Léon, C. (2016) · Blood · doi:10.1182/blood-2016-02-699959 · Cited by 79 · see citing works

Crucial role for CD 69 in allergic inflammatory responses: CD 69‐Myl9 system in the pathogenesis of airway inflammation

Kimura, M. Y., Hayashizaki, K., Tokoyoda, K., Takamura, S., Motohashi, S., & Nakayama, T. (2017) · Immunological Reviews · doi:10.1111/imr.12559 · Cited by 77 · see citing works

Mechanobiology of bone marrow stem cells: From myosin-II forces to compliance of matrix and nucleus in cell forms and fates

Shin, J., Swift, J., Ivanovska, I. L., Spinler, K. R., Buxboim, A., & Discher, D. E. (2013) · Differentiation · doi:10.1016/j.diff.2013.05.001 · Cited by 72 · see citing works

SRF selectively controls tip cell invasive behavior in angiogenesis

Franco, C. A., Blanc, J., Parlakian, A., Blanco, R., Aspalter, I. M., Kazakova, N., Diguet, N., Mylonas, E., Gao-Li, J., Vaahtokari, A., et al. (2013) · Development · doi:10.1242/dev.091074 · Cited by 72 · see citing works

Myosin light chains 9 and 12 are functional ligands for CD69 that regulate airway inflammation

Hayashizaki, K., Kimura, M. Y., Tokoyoda, K., Hosokawa, H., Shinoda, K., Hirahara, K., Ichikawa, T., Onodera, A., Hanazawa, A., Iwamura, C., et al. (2016) · Science Immunology · doi:10.1126/sciimmunol.aaf9154 · Cited by 70 · see citing works

MKL1 potentiates lung cancer cell migration and invasion by epigenetically activating MMP9 transcription

Cheng, X., Yang, Y., Fan, Z., Yu, L., Bai, H., Zhou, B., Wu, X., Xu, H., Fang, M., Shen, A., et al. (2015) · Oncogene · doi:10.1038/onc.2015.14 · Cited by 68 · see citing works

Tunneling nanotubes mediate the transfer of stem cell marker CD133 between hematopoietic progenitor cells

Reichert, D., Scheinpflug, J., Karbanová, J., Freund, D., Bornhäuser, M., & Corbeil, D. (2016) · Experimental Hematology · doi:10.1016/j.exphem.2016.07.006 · Cited by 64 · see citing works

MKL1 and MKL2 play redundant and crucial roles in megakaryocyte maturation and platelet formation

Smith, E. C., Thon, J. N., Devine, M. T., Lin, S., Schulz, V., Guo, Y., Massaro, S. A., Halene, S., Gallagher, P. G., Italiano, J. E., et al. (2012) · Blood · doi:10.1182/blood-2012-04-420828 · Cited by 62 · see citing works

A new therapeutic target: the CD69-Myl9 system in immune responses

Kimura, M. Y., Koyama‐Nasu, R., Yagi, R., & Nakayama, T. (2019) · Seminars in Immunopathology · doi:10.1007/s00281-019-00734-7 · Cited by 59 · see citing works

The abnormal proplatelet formation in MYH9‐related macrothrombocytopenia results from an increased actomyosin contractility and is rescued by myosin IIA inhibition

Chen, Y., Boukour, S., Milloud, R., Favier, R., Saposnik, B., Schlegel, N., Nurden, A. T., Raslová, H., Vainchenker, W., Balland, M., et al. (2013) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.12436 · Cited by 51 · see citing works

Induction of megakaryocyte differentiation drives nuclear accumulation and transcriptional function of MKL1 via actin polymerization and RhoA activation

Smith, E. C., Teixeira, A. M., Chen, R. C., Wang, L., Gao, Y., Hahn, K. L., & Krause, D. S. (2012) · Blood · doi:10.1182/blood-2012-05-429993 · Cited by 49 · see citing works

Megakaryocyte polyploidization: role in platelet production

Vainchenker, W., & Raslová, H. (2019) · Platelets · doi:10.1080/09537104.2019.1667497 · Cited by 49 · see citing works

Megakaryocytic Leukemia 1 Directs a Histone H3 Lysine 4 Methyltransferase Complex to Regulate Hypoxic Pulmonary Hypertension

Chen, D., Yang, Y., Cheng, X. F., Fang, F., Xu, G., Yuan, Z., Xia, J., Kong, H., Xie, W., Wang, H., et al. (2015) · Hypertension · doi:10.1161/hypertensionaha.114.04585 · Cited by 47 · see citing works

The landscape of prognostic and immunological role of myosin light chain 9 (MYL9) in human tumors

Lv, M., Luo, L., & Chen, X. (2021) · Immunity Inflammation and Disease · doi:10.1002/iid3.557 · Cited by 46 · see citing works

Inherited thrombocytopenia: novel insights into megakaryocyte maturation, proplatelet formation and platelet lifespan

Johnson, B., Fletcher, S. J., & Morgan, N. V. (2016) · Platelets · doi:10.3109/09537104.2016.1148806 · Cited by 46 · see citing works

Platelet counts as a biomarker in ANCA-associated vasculitis

Willeke, P., Kümpers, P., Schlüter, B., Limani, A., Becker, H., & Schotte, H. (2015) · Scandinavian Journal of Rheumatology · doi:10.3109/03009742.2015.1006247 · Cited by 45 · see citing works

MKL1 deficiency results in a severe neutrophil motility defect due to impaired actin polymerization

Sprenkeler, E. G. G., Henriet, S., Tool, A. T. J., Kreft, I. C., van der Bijl, I., Aarts, C. E. M., van Houdt, M., Verkuijlen, P., van Aerde, K., Jaspers, G. J., et al. (2020) · Blood · doi:10.1182/blood.2019002633 · Cited by 44 · see citing works

Celastrol Ameliorates EAE Induction by Suppressing Pathogenic T Cell Responses in the Peripheral and Central Nervous Systems

Wang, Y., Cao, L., Xu, L., Cao, F., Peng, B., Zhang, X., Shen, Y.-F., Uzan, G., & Zhang, D. (2015) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-015-9598-9 · Cited by 43 · see citing works

MKLs: Co-factors of serum response factor (SRF) in neuronal responses

Kalita, K. B., Kuźniewska, B., & Kaczmarek, L. (2012) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2012.05.008 · Cited by 43 · see citing works

Thrombocytopenia induced by the histone deacetylase inhibitor abexinostat involves p53-dependent and -independent mechanisms

Ali, A., Bluteau, O., Messaoudi, K., Palazzo, A., Boukour, S., Lordier, L., Lécluse, Y., Rameau, P., Kraus‐Berthier, L., Jacquet-Bescond, A., et al. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.260 · Cited by 40 · see citing works

Serum response factor is an essential transcription factor in megakaryocytic maturation

Halene, S., Gao, Y., Hahn, K. L., Massaro, S. A., Italiano, J. E., Schulz, V., Lin, S., Kupfer, G. M., & Krause, D. S. (2010) · Blood · doi:10.1182/blood-2010-01-261743 · Cited by 40 · see citing works

MRTFs‐ master regulators of EMT

Gasparics, Á., & Sebe, A. (2017) · Developmental Dynamics · doi:10.1002/dvdy.24544 · Cited by 38 · see citing works

Acute Megakaryocytic LeukemiaPreprint

McNulty, M., & Crispino, J. D. (2019) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a034884 · Cited by 37 · see citing works

Expression and prognostic significance of MYL9 in esophageal squamous cell carcinoma

Wang, J.-H., Zhang, L., Huang, S.-T., Xu, J., Zhou, Y., Yu, X., Luo, R.-Z., Wen, Z.-S., Jia, W.-H., & Zheng, M. (2017) · PLoS ONE · doi:10.1371/journal.pone.0175280 · Cited by 36 · see citing works

Calpain 2 Activation of P-TEFb Drives Megakaryocyte Morphogenesis and Is Disrupted by Leukemogenic GATA1 Mutation

Elagib, K. E., Rubinstein, J. D., Delehanty, L. L., Ngoh, V. S., Greer, P. A., Li, S., Lee, J. K., Li, Z., Orkin, S. H., Mihaylov, I. S., et al. (2013) · Developmental Cell · doi:10.1016/j.devcel.2013.11.013 · Cited by 33 · see citing works

The transcription factor Srf regulates hematopoietic stem cell adhesion

Ragu, C., Elain, G., Mylonas, E., Ottolenghi, C., Cagnard, N., Daegelen, D., Passegue, E. A., Vainchenker, W., Bernard, O., & Penard‐Lacronique, V. (2010) · Blood · doi:10.1182/blood-2009-11-251587 · Cited by 32 · see citing works

The serum response factor (SRF)/megakaryocytic acute leukemia (MAL) network participates in megakaryocyte development

Ragu, C., Boukour, S., Elain, G., Wagner‐Ballon, O., Raslová, H., Debili, N., Olson, E. N., Daegelen, D., Vainchenker, W., Bernard, O., et al. (2010) · Leukemia · doi:10.1038/leu.2010.80 · Cited by 32 · see citing works

NF-E2 p45 Is Important for Establishing Normal Function of Platelets

Fujita, R., Takayama-Tsujimoto, M., Satoh, H., Gutiérrez, L., Aburatani, H., Fujii, S., Sarai, A., Bresnick, E. H., Yamamoto, M. P., & Motohashi, H. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.01274-12 · Cited by 31 · see citing works

MRTFA: A critical protein in normal and malignant hematopoiesis and beyond

Reed, F. E., Larsuel, S. T., Mayday, M. Y., Scanlon, V. M., & Krause, D. S. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.100543 · Cited by 29 · see citing works

Development of a Bioinformatics Framework for Identification and Validation of Genomic Biomarkers and Key Immunopathology Processes and Controllers in Infectious and Non-infectious Severe Inflammatory Response Syndrome

Tong, D. L., Kempsell, K. E., Szakmány, T., & Ball, G. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00380 · Cited by 29 · see citing works

Role of Rho-GTPases in megakaryopoiesis

Vainchenker, W., Arkoun, B., Basso‐Valentina, F., Lordier, L., Debili, N., & Raslová, H. (2021) · Small GTPases · doi:10.1080/21541248.2021.1885134 · Cited by 28 · see citing works

Systems Pharmacogenomics Finds RUNX1 Is an Aspirin-Responsive Transcription Factor Linked to Cardiovascular Disease and Colon Cancer

Voora, D., Rao, A. K., Jalagadugula, G. S., Myers, R. A., Harris, E. M., Ortel, T. L., & Ginsburg, G. S. (2016) · EBioMedicine · doi:10.1016/j.ebiom.2016.08.021 · Cited by 26 · see citing works

RhoA/Cdc42 signaling drives cytoplasmic maturation but not endomitosis in megakaryocytes

Heib, T., Hermanns, H. M., Manukjan, G., Englert, M., Kusch, C., Becker, I. C., Gerber, A., Wackerbarth, L. M., Burkard, P., Dandekar, T., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109102 · Cited by 25 · see citing works

Expression pattern and prognostic significance of myosin light chain 9 (MYL9): a novel biomarker in glioblastoma

Kruthika, B. S., Sugur, H. S., Kanuri, N. N., Arivazhagan, A., Kondaiah, P., & Santosh, V. (2019) · Journal of Clinical Pathology · doi:10.1136/jclinpath-2019-205834 · Cited by 24 · see citing works

Enhancer-associated aortic valve stenosis risk locus 1p21.2 alters NFATC2 binding site and promotes fibrogenesis

Chignon, A., Rosa, M., Boulanger, M.-C., Argaud, D., Devillers, R., Bon-Baret, V., Mkannez, G., Li, Z., Rufiange, A., Gaudreault, N., et al. (2021) · iScience · doi:10.1016/j.isci.2021.102241 · Cited by 18 · see citing works

Impact of supervised beego, a traditional Chinese water-only fasting, on thrombosis and haemostasis

Fang, Y., Gu, Y., Zhao, C., Lv, Y., Qian, J., Zhu, L., Yuan, N., Zhang, S., Wang, L., Li, M., et al. (2021) · BMJ Nutrition, Prevention &amp; Health · doi:10.1136/bmjnph-2020-000183 · Cited by 19 · see citing works

SMYD3-associated pathway is involved in the anti-tumor effects of sulforaphane on gastric carcinoma cells

Dong, Q., Wang, Q., Wang, L., Jiang, Y., Liu, M., Hu, H., Liu, Y., Zhou, H., He, H., Zhang, T., et al. (2018) · Food Science and Biotechnology · doi:10.1007/s10068-018-0337-x · Cited by 19 · see citing works

Assessment of Megakaryocyte Migration and Chemotaxis

Mazharian, A. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-307-3_19 · Cited by 17 · see citing works

CD4+ T cells in inflammatory diseases: pathogenic T-helper cells and the CD69–Myl9 system

Nakayama, T., Hirahara, K., Kimura, M. Y., Iwamura, C., Kiuchi, M., Kokubo, K., Onodera, A., Hashimoto, K., & Motohashi, S. (2021) · International Immunology · doi:10.1093/intimm/dxab053 · Cited by 16 · see citing works

Dynamins 2 and 3 control the migration of human megakaryocytes by regulating CXCR4 surface expression and ITGB1 activity

Suraneni, P. K., Corey, S. J., Hession, M. J., Ishaq, R., Awomolo, A., Hasan, S., Shah, C., Liu, H., Wickrema, A., Debili, N., et al. (2018) · Blood Advances · doi:10.1182/bloodadvances.2018021923 · Cited by 16 · see citing works

Generation of transgenic zebrafish with 2 populations of RFP- and GFP-labeled thrombocytes: analysis of their lipids

Fallatah, W., Silva, I. W. D., Verbeck, G. F., & Jagadeeswaran, P. (2019) · Blood Advances · doi:10.1182/bloodadvances.2018023960 · Cited by 15 · see citing works

An intronic deletion in megakaryoblastic leukemia 1 is associated with hyperproliferation of B cells in triplets with Hodgkin lymphoma

Record, J., Sendel, A., Kritikou, J. S., Kuznetsov, N. V., Brauner, H., He, M., Nagy, N., Oliveira, M. M. S., Griseti, E., Haase, C. B., et al. (2019) · Haematologica · doi:10.3324/haematol.2019.216317 · Cited by 13 · see citing works

Hemophagocytosis by Leukemic Megakaryoblasts in Acute Myeloid Leukemia (Megakaryoblastic) With t(1;22)(p13;q13);RBM15-MKL1

Wiseman, D. H., Bonney, D. K., & Wynn, R. F. (2012) · Journal of Pediatric Hematology/Oncology · doi:10.1097/mph.0b013e318245a027 · Cited by 12 · see citing works

Actin cytoskeleton depolymerization increases matrix metalloproteinase gene expression in breast cancer cells by promoting translocation of cysteine-rich protein 2 to the nucleus

Mgrditchian, T., Brown-Clay, J. D., Hoffmann, C., Müller, T., Filali, L., Ockfen, E., Mao, X., Moreau, F., Casellas, C. P., Kaoma, T., et al. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1100938 · Cited by 11 · see citing works

CK2α promotes advanced glycation end products-induced expressions of fibronectin and intercellular adhesion molecule-1 via activating MRTF-A in glomerular mesangial cells

Chen, Z., Chen, Q., Huang, J., Gong, W., Zou, Y., Zhang, L., Liu, P., & Huang, H. (2017) · Biochemical Pharmacology · doi:10.1016/j.bcp.2017.12.002 · Cited by 10 · see citing works

Glia maturation factor beta deficiency protects against diabetic osteoporosis by suppressing osteoclast hyperactivity

Shi, S., Gu, H., Xu, J., Sun, W., Liu, C., Zhu, T., Wang, J., Gao, F., Zhang, J., Ou, Q., et al. (2023) · Experimental & Molecular Medicine · doi:10.1038/s12276-023-00980-8 · Cited by 8 · see citing works

MYL9 deficiency is neonatal lethal in mice due to abnormalities in the lung and the muscularis propria of the bladder and intestine

Huang, C.-H., Schuring, J., Skinner, J. P. J., Mok, L., & Chong, M. M. W. (2022) · PLoS ONE · doi:10.1371/journal.pone.0270820 · Cited by 6 · see citing works

Leukemias, Lymphomas, and Other Related Disorders

Zhang, Y., & Rowley, J. D. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-383834-6.00079-3 · Cited by 5 · see citing works

Molecular and Cellular Biology of Platelet Formation

Italiano, J. E., & Schulze, H. (2016) · Springer eBooks · doi:10.1007/978-3-319-39562-3 · Cited by 6 · see citing works

Endomitosis: a new cell fate in the cell cycle leading to polyploidy in megakaryocytes and hepatocytes

Hua, Q., Zhang, X.-C., Tian, R.-F., She, Z.-G., & Huang, Z. (2025) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b2400127 · Cited by 4 · see citing works

Single-nuclei transcriptome analysis of IgM+ cells isolated from channel catfish (Ictalurus punctatus) spleen

Aldersey, J. E., Abernathy, J. W., Beck, B. H., & Lange, M. D. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1547193 · Cited by 4 · see citing works

Biphasic Effect of Thyroid Hormone on Megakaryopoiesis and Platelet Production

Xu, B., Ye, X., Wen, Z., Shen, M., Chen, M., Shen, M., Xu, Y., Wang, J., & Chen, S. (2024) · Thyroid · doi:10.1089/thy.2024.0361 · Cited by 4 · see citing works

MAL: not just a leukemia inducer

Ravid, K. (2009) · Blood · doi:10.1182/blood-2009-09-242818 · Cited by 4 · see citing works

Developmental and hormonal regulation of Arabidopsis thaliana ornithine-delta-aminotransferase

Egorova, A. A., Gerasimova, S. V., & Kochetov, A. V. (2022) · Vavilov Journal of Genetics and Breeding · doi:10.18699/vjgb-22-19 · Cited by 3 · see citing works

Identification of the MRTFA/SRF pathway as a critical regulator of quiescence in cancerPreprint

Panesso-Gómez, S., Cole, A. J., Wield, A. M., Anyaeche, V. I., Shah, J. S., Jiang, Q., Ebai, T., Sharrow, A. C., Tseng, G. C., Yoon, E., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.11.15.623825 · Cited by 3 · see citing works

Identification of the MRTFA/SRF pathway as a critical regulator of quiescence and chemotherapy resistance in cancer

Panesso-Gómez, S., Cole, A. J., Arrigo, A., Roberts, A., Bello, M. G., Wield, A. M., Anyaeche, V. I., McGonigal, S. C., Hijazi, A., Shah, J. S., et al. (2026) · Cancer Letters · doi:10.1016/j.canlet.2026.218435 · Cited by 2 · see citing works

A machine learning-based megakaryocyte identification system uncovers resident organs, markers, and functional diversity

Xia, M., Ma, Y., Cai, Y., Zhao, J., Zhong, Y., Guo, S., Li, M., Su, P., Shen, B., He, H., et al. (2026) · Developmental Cell · doi:10.1016/j.devcel.2026.04.005 · Cited by 2 · see citing works

Transcriptional Regulation of Platelet Formation: Harnessing the Complexity for Efficient Platelet Production In Vitro

Tijssen, M. R., Moreau, T., & Ghevaert, C. (2016) · Springer eBooks · doi:10.1007/978-3-319-39562-3_2 · Cited by 2 · see citing works

Thrombocytopenia: A Defect in Actin Dynamics?

Standing, A. S. I. (2017) · EMJ Hematology · doi:10.33590/emjhematol/10314114 · Cited by 2 · see citing works

A song of heads and tails: myosin II conformational regulation and filament dynamics shape force generation in non-muscle cells

Perez-Diaz, R., Garrido-Casado, M., Ramos-Solano, H., Llorente-González, C., Talayero, V. C., & Vicente‐Manzanares, M. (2026) · Biophysical Reviews · doi:10.1007/s12551-026-01414-1 · Cited by 2 · see citing works

Megakaryocytes muscle in

Tong, W. (2010) · Blood · doi:10.1182/blood-2010-06-291369

Exploring the regulation of megakaryocytic differentiation and platelet production by mechanical forces and cell-derived microparticles

Jiang, J. (2024) · Library, Museums and Press - UDSpace (University of Delaware) · doi:10.58088/zt95-kd54

Identification and Characterization of the Interaction between VPS33B and SNAREs

Puhacz, M. (2011) · TSpace (University of Toronto)

Neutrophil migration in primary immunodeficiency

Record, J. (2018) · UCL Discovery (University College London)

Identification of Hub Genes Associated with Development of Lung Adenocarcinoma by Integrated Bioinformatics AnalysisPreprint

Li, J., & Hou, W. (2021) · Research Square · doi:10.21203/rs.3.rs-550498/v1

The Role of DIAPH1 in the Megakaryopoiesis

Pan, J. (2014) · doi:10.70675/3d0829d2zfc18z4bc0z8e26ze0030ccb042f

The role of histone deacetylase 3 (HDAC3) during megakaryopoiesis

Ishaq, R. (2020) · doi:10.70675/08096a2ez3ccaz4219za256zfb0a9d758e0e

Voies de mort cellulaire et signalisation au cours de la différenciation mégacaryocytaire de cellules érythroleucémiques humaines (HELs)

Diab, D. (2021) · doi:10.70675/2441d4a3zb993z4183za036z1614bc273db8

Physiopathological mechanisms leading to two congenital thrombocytopenias, congenital amegakaryocytic thrombocytopenia (CAMT) and thrombocytopenia 2 (THC2)

Basso‐Valentina, F. (2021) · theses.fr (ABES) · doi:10.70675/a56f0f8bz6734z40fbzb826z92de65ef65ce

Régulation de l'arrêt des endomitoses et de la différenciation mégacaryocytaire terminale : rôle de p19 INK4D et de MAL

Gendre-Gilles, L. (2009)

The serum response factor (SRF)/megakaryocytic acute leukemia (MAL) network participates in megakaryocyte development

Ragu, C., Boukour, S., Elain, G., Wagner‐Ballon, O., Raslová, H., Debili, N., Olson, E. N., Daegelen, D., Vainchenker, W., Bernard, O., et al. (2010) · Leukemia · doi:10.1038/leu.2010.80 · Cited by 32 · see citing works

Denser matters

Ariëns, R. A. S. (2009) · Blood · doi:10.1182/blood-2009-09-239921 · Cited by 3 · see citing works

Stromal-derived factor 1–induced megakaryocyte migration and platelet production is dependent on matrix metalloproteinases

Lane, W. J., Dias, S., Hattori, K., Heissig, B., Choy, M., Rabbany, S. Y., Wood, J. M., Moore, M. A. S., & Rafii, S. (2000) · Blood · doi:10.1182/blood.v96.13.4152 · Cited by 162 · see citing works

Serum response factor is an essential transcription factor in megakaryocytic maturation

Halene, S., Gao, Y., Hahn, K. L., Massaro, S. A., Italiano, J. E., Schulz, V., Lin, S., Kupfer, G. M., & Krause, D. S. (2010) · Blood · doi:10.1182/blood-2010-01-261743 · Cited by 40 · see citing works