Notch/HES1-mediated PARP1 activation: a cell type–specific mechanism for tumor suppression
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Notch signaling plays both oncogenic and tumor suppressor roles, depending on cell type. In contrast to T-cell acute lymphoblastic leukemia (ALL), where Notch activation promotes leukemogenesis, induction of Notch signaling in B-cell ALL (B-ALL) leads to growth arrest and apoptosis. The Notch target Hairy/Enhancer of Split1 (HES1) is sufficient to reproduce this tumor suppressor phenotype in B-ALL; however, the mechanism is not yet known. We report that HES1 regulates proapoptotic signals by the novel interacting protein Poly ADP-Ribose Polymerase1 (PARP1) in a cell type–specific manner. Interaction of HES1 with PARP1 inhibits HES1 function, induces PARP1 activation, and results in PARP1 cleavage in B-ALL. HES1-induced PARP1 activation leads to self-ADP ribosylation of PARP1, consumption of nicotinamide adenine dinucleotide+, diminished adenosine triphosphate levels, and translocation of apoptosis-inducing factor from mitochondria to the nucleus, resulting in apoptosis in B-ALL but not T-cell ALL. Importantly, induction of Notch signaling by the Notch agonist peptide Delta/Serrate/Lag-2 can reproduce these events and leads to B-ALL apoptosis. The novel interaction of HES1 and PARP1 in B-ALL modulates the function of the HES1 transcriptional complex and signals through PARP1 to induce apoptosis. This mechanism shows a cell type–specific proapoptotic pathway that may lead to Notch agonist–based cancer therapeutics.
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PARP1 activation can be induced by stress responses other than DNA damage, including ERK-1, Notch/HES-1, and intracellular calcium overload.
“In addition, as reviewed by Weaver and Yang 94, PARP1 activation can be induced by stress responses other than DNA damage, including the ERK-1 95, 96 and Notch/HES-1 97 signaling pathways and intracellular calcium overload 98.”
From Xeroderma Pigmentosa Group A (XPA), Nucleotide Excision Repair and Regulation by ATR in Response to Ultraviolet Irradiation (2017) · cites this paper as [97]
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Prognostic Significance of Hes-1, a Downstream Target of Notch Signaling in Hepatocellular Carcinoma
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Notch signaling in the tumor microenvironment: recent advances and targeted therapeutics
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PARP-1 and CASP3 genes are up-regulated in LNCaP and PC-3 prostate cancer cell lines
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NOTCH signaling in the pathogenesis of splenic marginal zone lymphoma—opportunities for therapy
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Effect of Notch and PARP Pathways’ Inhibition in Leukemic Cells
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Differential expression of PARP1 mRNA in leucocytes of patients with Down’s syndrome
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Molecular crosstalk: Notch can manipulate Hes1 and miR-9 behavior
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Notch1 signaling is irresponsible to the anti-leukemic effect of HDACis in B-ALL Nalm-6 cells
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ICBP90 mediates Notch signaling to facilitate human hepatocellular carcinoma growth
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Notch pathway connections in primary leukaemia samples of limited size
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Lycopene protects against acute kidney injury by suppressing PARP/NOTCH-mediated inflammation
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RBPJ Role in Cancer Immunotherapy
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Dysregulation of metallothionein MT1 sub-types in TCF3::PBX1 pre-B-cell acute lymphoblastic leukemia
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Poly (ADP-Ribose) Polymerase 1 Protein Expression in Normal Pancreas and Pancreatic Adenocarcinoma
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Mechanisms of Notch signaling specificity in lymphocytes and their leukemic counterparts
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Poly (ADP-ribose) polymerase 1 expression in fibroblasts of Down syndrome subjects
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THE SHORT-TERM EFFECTS OF LOW-DOSE-RATE RADIATION ON EL4 LYMPHOMA CELL
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The emerging role of NOTCH target genes in Egyptian childhood acute lymphoblastic leukemia
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Proteome profiling reveals HES1-driven mitotic catastrophe in ovarian serous carcinomaPreprint
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RBPJ Role in Cancer Immunotherapy
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Regulation of chromatin structure and function by adenosine diphosphate (ADP)-ribosylation
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- Authors
- Kannan, S., Fang, W., Song, G., Mullighan, C. G., Hammitt, R., McMurray, J., & Zweidler-McKay, P. A.
- Affiliations
- The University of Texas MD Anderson Cancer Center (US)
- St. Jude Children's Research Hospital (US)
- Division of Pediatrics, The University of Texas M. D. Anderson Cancer Center, Houston, TX;
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2011-03-10
- Volume
- 117
- Issue
- 10
- Pages
- 2891-2900
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- PMC
- PMC3062299
- OpenAlex
- W2094611687
- Cited by
- 66
- References
- 50
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 4 · 2023: 1 · 2022: 3 · 2021: 3 · 2020: 5 · 2019: 3 · 2018: 4 · 2017: 1 · 2016: 2 · 2015: 4 · 2014: 8 · 2013: 9 · 2012: 7
- FWCI
- 3.51
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Blood (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (R01CA138816, K08CA101934)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Acute Lymphoblastic Leukemia research
- Keywords
- Notch signaling, Hes1, PARP1, B-cell acute lymphoblastic leukemia, T-cell acute lymphoblastic leukemia, apoptosis, tumor suppression, cell type-specific signaling, PARP-1 cleavage, ADP-ribosylation, apoptosis-inducing factor, mitochondrial translocation
- MeSH terms
- Poly (ADP-Ribose) Polymerase-1, Transcription Factor HES-1, Cell Separation, Child, Enzyme Activation, Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Humans, Poly(ADP-ribose) Polymerases, RNA, Messenger, Transfection, Signal Transduction, Precursor B-Cell Lymphoblastic Leukemia-Lymphoma, Genes, Tumor Suppressor, Apoptosis, Homeodomain Proteins, Cell Line, Tumor, Chromatin Immunoprecipitation, Basic Helix-Loop-Helix Proteins, Basic Helix-Loop-Helix Transcription Factors, Receptors, Notch, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
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