Role of complement and Fcγ receptors in the protective activity of the long pentraxin PTX3 against Aspergillus fumigatus

Moalli, Federica; Doni, Andrea; Deban, Livija; Zelante, Teresa; Zagarella, Silvia; Bottazzi, Barbara; Romani, Luigina; Mantovani, Alberto; Garlanda, Cecilia

doi:10.1182/blood-2009-12-258376

Role of complement and Fcγ receptors in the protective activity of the long pentraxin PTX3 against Aspergillus fumigatus

Pentraxin 3 (PTX3) is a soluble pattern recognition molecule playing a nonredundant role in resistance against Aspergillus fumigatus. The present study was designed to investigate the molecular pathways involved in the opsonic activity of PTX3. The PTX3 N-terminal domain was responsible for conid…