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Improved outcome with hematopoietic stem cell transplantation in a poor prognostic subgroup of infants with mixed-lineage-leukemia (MLL)–rearranged acute lymphoblastic leukemia: results from the Interfant-99 Study
Open accessAbstract
To define a role for hematopoietic stem cell transplantation (HSCT) in infants with acute lymphoblastic leukemia and rearrangements of the mixed-lineage-leukemia gene (MLL+), we compared the outcome of MLL+ patients from trial Interfant-99 who either received chemotherapy only or HSCT. Of 376 patients with a known MLL status in the trial, 297 (79%) were MLL+. Among the 277 of 297 MLL+ patients (93%) in first remission (CR), there appeared to be a significant difference in disease-free survival (adjusted by waiting time to HSCT) between the 37 (13%) who received HSCT and the 240 (87%) who received chemotherapy only (P = .03). However, the advantage was restricted to a subgroup with 2 additional unfavorable prognostic features: age less than 6 months and either poor response to steroids at day 8 or leukocytes more than or equal to 300 g/L. Ninety-seven of 297 MLL+ patients (33%) had such high-risk criteria, with 87 achieving CR. In this group, HSCT was associated with a 64% reduction in the risk of failure resulting from relapse or death in CR (hazard ratio = 0.36, 95% confidence interval, 0.15-0.86). In the remaining patients, there was no advantage for HSCT over chemotherapy only. In summary, HSCT seems to be a valuable option for a subgroup of infant MLL+ acute lymphoblastic leukemia carrying further poor prognostic factors. The trial was registered at www.clinicaltrials.gov as #NCT00015873 and at www.controlled-trials.com as #ISRCTN24251487.
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Cited by
Inaba, H., Greaves, M., & Mullighan, C. G. (2013) · The Lancet · doi:10.1016/s0140-6736(12)62187-4 · Cited by 1,074
Childhood Acute Lymphoblastic Leukemia: Progress Through Collaboration
Pui, C.-H., Yang, J. J., Hunger, S. P., Pieters, R., Schrappe, M., Biondi, A., Vora, A., Baruchel, A., Silverman, L. B., Schmiegelow, K., et al. (2015) · Journal of Clinical Oncology · doi:10.1200/jco.2014.59.1636 · Cited by 1,007
Self-citationSureda, A., Bader, P., Cesaro, S., Dreger, P., Duarte, R. F., Dufour, C., Falkenburg, J. H. F., Farge-Bancel, D., Gennery, A., Kröger, N., et al. (2015) · Bone Marrow Transplantation · doi:10.1038/bmt.2015.6 · Cited by 337
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Metadata
- Authors
- Mann, G., Attarbaschi, A., Schrappe, M., De Lorenzo, P., Peters, C., Hann, I., De Rossi, G., Felice, M., Lausen, B., LeBlanc, T., Szczepanski, T., Ferster, A., Janka-Schaub, G., Rubnitz, J., Silverman, L. B., Stary, J., Campbell, M., Li, C. K., Suppiah, R., Biondi, A., Vora, A., Valsecchi, M. G., Pieters, R., & on behalf of the Interfant-99 Study Group
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2010-10-14
- Volume
- 116
- Issue
- 15
- Pages
- 2644-2650
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2064396597
- Cited by
- 164
- References
- 0
- FWCI
- 7.75
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Improved outcome with hematopoietic stem cell transplantation in a poor prognostic subgroup of infants with mixed-lineage-leukemia (MLL)–rearranged acute lymphoblastic leukemia: results from the Interfant-99 Study. https://app.cochat.ai/papers/10.1182/blood-2010-03-273532
- The paper
- Mann, G., Attarbaschi, A., Schrappe, M., De Lorenzo, P., Peters, C., Hann, I., De Rossi, G., Felice, M., Lausen, B., LeBlanc, T., Szczepanski, T., Ferster, A., Janka-Schaub, G., Rubnitz, J., Silverman, L. B., Stary, J., Campbell, M., Li, C. K., Suppiah, R., . . . on behalf of the Interfant-99 Study Group. (2010). Improved outcome with hematopoietic stem cell transplantation in a poor prognostic subgroup of infants with mixed-lineage-leukemia (MLL)–rearranged acute lymphoblastic leukemia: results from the Interfant-99 Study. Blood. https://doi.org/10.1182/blood-2010-03-273532
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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