Student or educator? Sign up with your school email and get 6 months of Pro free.
Cited by 1,007

The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

Childhood Acute Lymphoblastic Leukemia: Progress Through Collaboration

Open access
Pui, Ching-Hon, Yang, Jun J., Hunger, Stephen P., Pieters, Rob, Schrappe, Martin, Biondi, Andrea, Vora, Ajay, Baruchel, André, Silverman, Lewis B., Schmiegelow, Kjeld, Escherich, Gabriele, Horibe, Keizo, Benoit, Yves C.M., Izraeli, Shai, Yeoh, Allen Eng Juh, Liang, Der-Cherng, Downing, James R., Evans, William E., Relling, Mary V., Mullighan, Charles G.·2015·Journal of Clinical Oncology

Abstract

Purpose: To review the impact of collaborative studies on advances in the biology and treatment of acute lymphoblastic leukemia (ALL) in children and adolescents. Methods: A review of English literature on childhood ALL focusing on collaborative studies was performed. The resulting article was reviewed and revised by the committee chairs of the major ALL study groups. Results: With long-term survival rates for ALL approaching 90% and the advent of high-resolution genome-wide analyses, several international study groups or consortia were established to conduct collaborative research to further improve outcome. As a result, treatment strategies have been improved for several subtypes of ALL, such as infant, MLL-rearranged, Philadelphia chromosome–positive, and Philadelphia chromosome–like ALL. Many recurrent genetic abnormalities that respond to tyrosine kinase inhibitors and multiple genetic determinants of drug resistance and toxicities have been identified to help develop targeted therapy. Several genetic polymorphisms have been recognized that show susceptibility to developing ALL and that help explain the racial/ethnic differences in the incidence of ALL. Conclusion: The information gained from collaborative studies has helped decipher the heterogeneity of ALL to help improve personalized treatment, which will further advance the current high cure rate and the quality of life for children and adolescents with ALL.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1200/jco.2014.59.1636

Cites

5 of 5 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 5 references

Cited by

See all 1,007

Metadata

Authors
Pui, C.-H., Yang, J. J., Hunger, S. P., Pieters, R., Schrappe, M., Biondi, A., Vora, A., Baruchel, A., Silverman, L. B., Schmiegelow, K., Escherich, G., Horibe, K., Benoit, Y. C. M., Izraeli, S., Yeoh, A. E. J., Liang, D.-C., Downing, J. R., Evans, W. E., Relling, M. V., & Mullighan, C. G.
Venue
Journal of Clinical Oncology
Published
2015-09-20
Volume
33
Issue
27
Pages
2938-2948
ISSN
  • 0732-183X (ISSN-L)
  • 1527-7755
OpenAlex
W2125277492
Cited by
1,007
References
5
FWCI
66.97
Type
journal article
Language
en
Open access
green

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Childhood Acute Lymphoblastic Leukemia: Progress Through Collaboration. https://app.cochat.ai/papers/10.1200/jco.2014.59.1636
The paper
Pui, C.-H., Yang, J. J., Hunger, S. P., Pieters, R., Schrappe, M., Biondi, A., Vora, A., Baruchel, A., Silverman, L. B., Schmiegelow, K., Escherich, G., Horibe, K., Benoit, Y. C. M., Izraeli, S., Yeoh, A. E. J., Liang, D.-C., Downing, J. R., Evans, W. E., Relling, M. V., & Mullighan, C. G. (2015). Childhood Acute Lymphoblastic Leukemia: Progress Through Collaboration. Journal of Clinical Oncology. https://doi.org/10.1200/jco.2014.59.1636

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.