The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
B cells in early and chronic HIV infection: evidence for preservation of immune function associated with early initiation of antiretroviral therapy
Open accessAbstract
Characterization of lymphocytes including B cells during early versus chronic HIV infection is important for understanding the impact of chronic viremia on immune cell function. In this setting, we investigated B cells before and after reduction of HIV plasma viremia by antiretroviral therapy (ART). At baseline, peripheral blood B-cell counts were significantly lower in both early and chronic HIV-infected individuals compared with uninfected controls. Similar to CD4+ but not CD8+ T cells, B-cell numbers in both groups increased significantly after ART. At baseline, B cells of early HIV-infected individuals were composed of a higher percentage of plasmablasts and resting memory B cells compared with chronic HIV-infected individuals whose B cells were composed of a higher percentage of immature/transitional and exhausted B cells compared with their early infection counterparts. At 1 year after ART, the percentage of resting memory B cells remained higher in early compared with chronic HIV-infected individuals. This difference translated into a better functional profile in that memory B-cell responses to HIV and non-HIV antigens were superior in early- compared with chronic-treated HIV infected individuals. These findings provide new insights on B cells in HIV infection and how early initiation of ART may prevent irreversible immune system damage.
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Cites
Molecular Signature of CD8+ T Cell Exhaustion during Chronic Viral Infection
Wherry, E. J., Ha, S.-J., Kaech, S. M., Haining, W. N., Sarkar, S., Kalia, V., Subramaniam, S., Blattman, J. N., Barber, D. L., & Ahmed, R. (2007) · Immunity · doi:10.1016/j.immuni.2007.09.006 · Cited by 2,103
Lane, H. C., Masur, H., Edgar, L. C., Whalen, G., Rook, A. H., & Fauci, A. S. (1983) · New England Journal of Medicine · doi:10.1056/nejm198308253090803 · Cited by 1,600
Self-citationUpregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction
Trautmann, L., Janbazian, L., Chomont, N., Said, E. A., Gimmig, S., Bessette, B., Boulassel, M.-R., Delwart, E., Sepulveda, H., Balderas, R. S., et al. (2006) · Nature Medicine · doi:10.1038/nm1482 · Cited by 1,565
Molecular Signature of CD8+ T Cell Exhaustion during Chronic Viral Infection
Wherry, E. J., Ha, S.-J., Kaech, S. M., Haining, W. N., Sarkar, S., Kalia, V., Subramaniam, S., Blattman, J. N., Barber, D. L., & Ahmed, R. (2007) · Immunity · doi:10.1016/j.immuni.2007.11.006 · Cited by 1,354
Moir, S., Ho, J., Malaspina, A., Wang, W., DiPoto, A. C., O'Shea, M. A., Roby, G., Kottilil, S., Arthos, J., Proschan, M. A., et al. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20072683 · Cited by 901
Self-citationB cells in HIV infection and disease
Moir, S., & Fauci, A. S. (2009) · Nature Reviews Immunology · doi:10.1038/nri2524 · Cited by 702
Self-citationSex differences in the Toll-like receptor–mediated response of plasmacytoid dendritic cells to HIV-1
Meier, A., Chang, J. J., Chan, E. S., Pollard, R. B., Sidhu, H. K., Kulkarni, S., Wen, T. F., Lindsay, R. J., Orellana, L., Mildvan, D., et al. (2009) · Nature Medicine · doi:10.1038/nm.2004 · Cited by 594
Pathogenesis of HIV infection: what the virus spares is as important as what it destroys
Grossman, Z., Meier-Schellersheim, M., Paul, W. E., & Picker, L. J. (2006) · Nature Medicine · doi:10.1038/nm1380 · Cited by 509
Atypical Memory B Cells Are Greatly Expanded in Individuals Living in a Malaria-Endemic Area
Weiss, G. E., Crompton, P. D., Li, S., Walsh, L. A., Moir, S., Traore, B., Kayentao, K., Ongoiba, A., Doumbo, O. K., & Pierce, S. K. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901297 · Cited by 470
Self-citationOxenius, A., Price, D. A., Easterbrook, P. J., O'Callaghan, C. A., Kelleher, A. D., Whelan, J. A., Sontag, G., Sewell, A. K., & Phillips, R. E. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.7.3382 · Cited by 389
Cited by
Sáez-Cirión, A., Bacchus, C., Hocqueloux, L., Avettand-Fenoel, V., Girault, I., Lecuroux, C., Potard, V., Versmisse, P., Melard, A., Prazuck, T., et al. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003211 · Cited by 1,011
Metadata
- Authors
- Moir, S., Buckner, C. M., Ho, J., Wang, W., Chen, J., Waldner, A. J., Posada, J. G., Kardava, L., O'Shea, M. A., Kottilil, S., Chun, T.-W., Proschan, M. A., & Fauci, A. S.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2010-12-16
- Volume
- 116
- Issue
- 25
- Pages
- 5571-5579
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W1991698426
- Cited by
- 282
- References
- 45
- FWCI
- 6.52
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The paper
- Moir, S., Buckner, C. M., Ho, J., Wang, W., Chen, J., Waldner, A. J., Posada, J. G., Kardava, L., O'Shea, M. A., Kottilil, S., Chun, T.-W., Proschan, M. A., & Fauci, A. S. (2010). B cells in early and chronic HIV infection: evidence for preservation of immune function associated with early initiation of antiretroviral therapy. Blood. https://doi.org/10.1182/blood-2010-05-285528
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