The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Early highly active antiretroviral therapy for acute HIV-1 infection preserves immune function of CD8+and CD4+T lymphocytes
Open accessAbstract
Highly active antiretroviral therapy (HAART) has been advocated for the management of primary HIV-1 infection without clear understanding of its immunological effects. Here, we demonstrate that early use of HAART during primary infection preserves HIV-specific CD8+T cells physically and functionally while HIV-specific T cell help is sustained. We also show that even transient administration of HAART at seroconversion can preserve HIV-specific immunity. In contrast, delayed initiation of HAART is associated with a progressive loss of HIV-specific CD8+T cells and absent HIV-specific T cell help. These results imply that HIV-specific T help is damaged during primary HIV-1 infection. Early drug treatment, which preserves this immunity, also preserves HIV-specific CD8+T cells. These results have implications for understanding the early pathogenesis of HIV-1 infection and suggest that acute HIV infection should be treated aggressively and as early as possible.
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Cites
Viral Immune Evasion Due to Persistence of Activated T Cells Without Effector Function
Zajac, A. J., Blattman, J. N., Murali-Krishna, K., Sourdive, D. J. D., Suresh, M., Altman, J. D., & Ahmed, R. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.12.2205 · Cited by 1,978
Cited by
Sáez-Cirión, A., Bacchus, C., Hocqueloux, L., Avettand-Fenoel, V., Girault, I., Lecuroux, C., Potard, V., Versmisse, P., Melard, A., Prazuck, T., et al. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003211 · Cited by 1,011
The immune response during acute HIV-1 infection: clues for vaccine development
McMichael, A. J., Borrow, P., Tomaras, G. D., Goonetilleke, N., & Haynes, B. F. (2010) · Nature Reviews Immunology · doi:10.1038/nri2674 · Cited by 871
Strain, M. C., Little, S. J., Daar, E. S., Havlir, D. V., Günthard, H. F., Lam, R. Y., Daly, O. A., Nguyen, J., Ignacio, C. C., Spina, C. A., et al. (2005) · The Journal of Infectious Diseases · doi:10.1086/428777 · Cited by 331
Moir, S., Buckner, C. M., Ho, J., Wang, W., Chen, J., Waldner, A. J., Posada, J. G., Kardava, L., O'Shea, M. A., Kottilil, S., et al. (2010) · Blood · doi:10.1182/blood-2010-05-285528 · Cited by 282
Tracking T cells with tetramers: new tales from new tools
Klenerman, P., Cerundolo, V., & Dunbar, P. R. (2002) · Nature Reviews Immunology · doi:10.1038/nri777 · Cited by 190
Metadata
- Authors
- Oxenius, A., Price, D. A., Easterbrook, P. J., O'Callaghan, C. A., Kelleher, A. D., Whelan, J. A., Sontag, G., Sewell, A. K., & Phillips, R. E.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2000-03-28
- Volume
- 97
- Issue
- 7
- Pages
- 3382-3387
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2026615262
- Cited by
- 389
- References
- 1
- FWCI
- 14.69
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Early highly active antiretroviral therapy for acute HIV-1 infection preserves immune function of CD8+and CD4+T lymphocytes. https://app.cochat.ai/papers/10.1073/pnas.97.7.3382
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- Oxenius, A., Price, D. A., Easterbrook, P. J., O'Callaghan, C. A., Kelleher, A. D., Whelan, J. A., Sontag, G., Sewell, A. K., & Phillips, R. E. (2000). Early highly active antiretroviral therapy for acute HIV-1 infection preserves immune function of CD8+and CD4+T lymphocytes. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.97.7.3382
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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