The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
FIP200 is required for the cell-autonomous maintenance of fetal hematopoietic stem cells
Open accessAbstract
Little is known about whether autophagic mechanisms are active in hematopoietic stem cells (HSCs) or how they are regulated. FIP200 (200-kDa FAK-family interacting protein) plays important roles in mammalian autophagy and other cellular functions, but its role in hematopoietic cells has not been examined. Here we show that conditional deletion of FIP200 in hematopoietic cells leads to perinatal lethality and severe anemia. FIP200 was cell-autonomously required for the maintenance and function of fetal HSCs. FIP200-deficient HSC were unable to reconstitute lethally irradiated recipients. FIP200 ablation did not result in increased HSC apoptosis, but it did increase the rate of HSC proliferation. Consistent with an essential role for FIP200 in autophagy, FIP200-null fetal HSCs exhibited both increased mitochondrial mass and reactive oxygen species. These data identify FIP200 as a key intrinsic regulator of fetal HSCs and implicate a potential role for autophagy in the maintenance of fetal hematopoiesis and HSCs.
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Cites
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Metadata
- Authors
- Liu, F., Lee, J. Y., Wei, H., Tanabe, O., Engel, J. D., Morrison, S. J., & Guan, J.-L.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2010-12-02
- Volume
- 116
- Issue
- 23
- Pages
- 4806-4814
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2068936500
- Cited by
- 231
- References
- 16
- FWCI
- 6.29
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Liu, F., Lee, J. Y., Wei, H., Tanabe, O., Engel, J. D., Morrison, S. J., & Guan, J.-L. (2010). FIP200 is required for the cell-autonomous maintenance of fetal hematopoietic stem cells. Blood. https://doi.org/10.1182/blood-2010-06-288589
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
