The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Engraftment of human central memory-derived effector CD8+ T cells in immunodeficient mice
Open accessAbstract
In clinical trials of adoptive T-cell therapy, the persistence of transferred cells correlates with therapeutic efficacy. However, properties of human T cells that enable their persistence in vivo are poorly understood, and model systems that enable investigation of the fate of human effector T cells (TE) have not been described. Here, we analyzed the engraftment of adoptively transferred human cytomegalovirus pp65-specific CD8+ TE cells derived from purified CD45RO+CD62L+ central memory (TCM) or CD45RO+CD62L− effector memory (TEM) precursors in an immunodeficient mouse model. The engraftment of TCM-derived effector cells (TCM/E) was dependent on human interleukin-15, and superior in magnitude and duration to TEM-derived effector cells (TEM/E). T-cell receptor Vβ analysis of persisting cells demonstrated that CD8+ TCM/E engraftment was polyclonal, suggesting that the ability to engraft is a general feature of TCM/E. CD8+ TEM/E proliferated extensively after transfer but underwent rapid apoptosis. In contrast, TCM/E were less prone to apoptosis and established a persistent reservoir of functional T cells in vivo characterized by higher CD28 expression. These studies predict that human CD8+ effector T cells derived from TCM precursors may be preferred for adoptive therapy based on superior engraftment fitness.
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mTOR regulates memory CD8 T-cell differentiation
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Louis, C. U., Savoldo, B., Dotti, G., Pule, M., Yvon, E., Myers, G. D., Rossig, C., Russell, H. V., Diouf, O., Liu, E., et al. (2011) · Blood · doi:10.1182/blood-2011-05-354449 · Cited by 1,163
Turtle, C. J., Hanafi, L.-A., Berger, C., Hudecek, M., Pender, B., Robinson, E., Hawkins, R., Chaney, C., Cherian, S., Chen, X., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aaf8621 · Cited by 1,016
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Metadata
- Authors
- Wang, X., Berger, C., Wong, C. W., Forman, S. J., Riddell, S. R., & Jensen, M. C.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2011-02-10
- Volume
- 117
- Issue
- 6
- Pages
- 1888-1898
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2098749176
- Cited by
- 159
- References
- 4
- FWCI
- 5.15
- Type
- journal article
- Language
- en
- Open access
- green
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- Wang, X., Berger, C., Wong, C. W., Forman, S. J., Riddell, S. R., & Jensen, M. C. (2011). Engraftment of human central memory-derived effector CD8+ T cells in immunodeficient mice. Blood. https://doi.org/10.1182/blood-2010-10-310599
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