A B-cell subset uniquely responsive to innate stimuli accumulates in aged mice

PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression

Day, C. L., Kaufmann, D. E., Kiepiela, P., Brown, J. A., Moodley, E. S., Reddy, S., Mackey, E. W., Miller, J. D., Leslie, A. J., DePierres, C., et al. (2006) · Nature · doi:10.1038/nature05115 · Cited by 2,680

Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection

Blackburn, S. D., Shin, H., Haining, W. N., Zou, T., Workman, C. J., Polley, A., Betts, M. R., Freeman, G. J., Vignali, D. A. A., & Wherry, E. J. (2009) · Nature Immunology · doi:10.1038/ni.1679 · Cited by 2,062

Chromatin–IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors

Leadbetter, E. A., Rifkin, I. R., Hohlbaum, A. M., Beaudette-Zlatanova, B. C., Shlomchik, M. J., & Marshak‐Rothstein, A. (2002) · Nature · doi:10.1038/416603a · Cited by 1,929

Viral Persistence Alters CD8 T-Cell Immunodominance and Tissue Distribution and Results in Distinct Stages of Functional Impairment

Wherry, E. J., Blattman, J. N., Murali‐Krishna, K., der Most, R. G. V., & Ahmed, R. (2003) · Journal of Virology · doi:10.1128/jvi.77.8.4911-4927.2003 · Cited by 1,645

Evidence for HIV-associated B cell exhaustion in a dysfunctional memory B cell compartment in HIV-infected viremic individuals

Moir, S. L., Ho, J., Malaspina, A., Wang, W., DiPoto, A. C., O’Shea, M. A., Roby, G. A., Kottilil, S., Arthos, J. A., Proschan, M. A., et al. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20072683 · Cited by 894

T Helper 17 Cells Promote Cytotoxic T Cell Activation in Tumor Immunity

Martín‐Orozco, N., Muranski, P. J., Chung, Y., Yang, X. O., Yamazaki, T., Lu, S., Hwu, P., Restifo, N. P., Overwijk, W. W., & Dong, C. (2009) · Immunity · doi:10.1016/j.immuni.2009.09.014 · Cited by 829

T‐cell exhaustion: characteristics, causes and conversion

Yi, J. S., Cox, M. A., & Zajac, A. J. (2010) · Immunology · doi:10.1111/j.1365-2567.2010.03255.x · Cited by 675

Effector and regulatory B cells: modulators of CD4+ T cell immunity

Lund, F. E., & Randall, T. D. (2010) · Nature reviews. Immunology · doi:10.1038/nri2729 · Cited by 636

Regulation of B Lymphocyte Responses to Foreign and Self-Antigens by the CD19/CD21 Complex

Fearon, D. T., Carroll, M. C., & Carroll, M. C. (2000) · Annual Review of Immunology · doi:10.1146/annurev.immunol.18.1.393 · Cited by 529

Complement receptor 2/CD21− human naive B cells contain mostly autoreactive unresponsive clones

Isnardi, I., Ng, Y.-S., Menard, L. C., Meyers, G., Saadoun, D., Srdanovic, I., Samuels, J., Berman, J., Buckner, J. H., Cunningham‐Rundles, C., et al. (2010) · Blood · doi:10.1182/blood-2009-09-243071 · Cited by 483

Selective emergence of antibody-secreting cells in the multiple sclerosis brain

Bogers, L., Engelenburg, H. J., Janssen, M., Unger, P.-P. A., Melief, M.-J., Wierenga-Wolf, A. F., Hsiao, C.-C., Mason, M. R. J., Hamann, J., van Langelaar, J., et al. (2023) · eBioMedicine · doi:10.1016/j.ebiom.2023.104465 · Cited by 40

Aging and respiratory viral infection: from acute morbidity to chronic sequelae

Wu, Y., Goplen, N. P., & Sun, J. (2021) · Cell & Bioscience · doi:10.1186/s13578-021-00624-2 · Cited by 42

Antibody Persistence 6 Months Post-Vaccination with BNT162b2 among Health Care Workers

Campo, F., Venuti, A., Pimpinelli, F., Abril, E., Blandino, G., Conti, L., VIRGILIO, A. D., Marco, F. D., Noia, V. D., Domenico, E. G. D., et al. (2021) · Vaccines · doi:10.3390/vaccines9101125 · Cited by 40

A roadmap for defining “extrafollicular” B cell responses

Eisenbarth, S. C., Batista, F. D., Cyster, J. G., Elsner, R. A., Kelsoe, G. H., Lund, F. E., Pillai, S. S., Sanz, I., Shlomchik, M. J., Toellner, K., et al. (2025) · Immunity · doi:10.1016/j.immuni.2025.08.007 · Cited by 46

Aging Converts Innate B1a Cells into Potent CD8+ T Cell Inducers

Lee-Chang, C., Bodogai, M., Moritoh, K., Chen, X., Wersto, R. P., Sen, R., Young, H. A., Croft, M., Ferrucci, L., & Biragyn, A. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1502034 · Cited by 40

T-bet expressing B cells – Novel target for autoimmune therapies?

Rubtsov, A. V., Marrack, P., & Rubtsova, K. (2017) · Cellular Immunology · doi:10.1016/j.cellimm.2017.04.011 · Cited by 40

COVID‐19 vaccination can occasionally trigger autoimmune phenomena, probably via inducing age‐associated B cells

Sachinidis, A., & Garyfallos, A. (2021) · International Journal of Rheumatic Diseases · doi:10.1111/1756-185x.14238 · Cited by 41

Assembly of a spatial circuit of T-bet–expressing T and B lymphocytes is required for antiviral humoral immunity

Mendoza, A., Yewdell, W. T., Hoyos, B. E., Schizas, M., Bou-Puerto, R., Michaels, A. J., Brown, C. C., Chaudhuri, J., & Rudensky, A. Y. (2021) · Science Immunology · doi:10.1126/sciimmunol.abi4710 · Cited by 38

Maturation trajectories and transcriptional landscape of plasmablasts and autoreactive B cells in COVID-19

Schultheiß, C., Paschold, L., Willscher, E., Simnica, D., Wöstemeier, A., Muscate, F., Wass, M., Eisenmann, S., Dutzmann, J., Keyßer, G., et al. (2021) · iScience · doi:10.1016/j.isci.2021.103325 · Cited by 38

B Cell Activation and Plasma Cell Differentiation Are Promoted by IFN-λ in Systemic Lupus Erythematosus

Barnas, J. L., Albrecht, J., Meednu, N., Alzamareh, D. F., Baker, C. D., McDavid, A., Looney, R. J., & Anolik, J. H. (2021) · The Journal of Immunology · doi:10.4049/jimmunol.2100339 · Cited by 39

Natural killer cells in aging and age-related diseases

Qi, C., & Liu, Q. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106156 · Cited by 41

The dangers of déjà vu: memory B cells as the cells of origin of ABC-DLBCLs

Venturutti, L., & Melnick, A. M. (2020) · Blood · doi:10.1182/blood.2020005857 · Cited by 39

Clonal expansion and functional exhaustion of monoclonal marginal zone B cells in mixed cryoglobulinemia: The yin and yang of HCV-driven lymphoproliferation and autoimmunity

Visentini, M., Conti, V., Cristofoletti, C., Lazzeri, C., Marrapodi, R., Russo, G., Casato, M., & Fiorilli, M. (2012) · Autoimmunity Reviews · doi:10.1016/j.autrev.2012.08.016 · Cited by 37

Age‐associated B cells expanded in autoimmune mice are memory cells sharing H‐CDR3‐selected repertoires

Aranburu, A., Höök, N., Gerasimčik, N., Corleis, B., Ren, W., Camponeschi, A., Carlsten, H., Grimsholm, O., & Mårtensson, I. (2017) · European Journal of Immunology · doi:10.1002/eji.201747127 · Cited by 37

Hyper‐metabolic B cells in the spleens of old mice make antibodies with autoimmune specificities

Frasca, D., Romero, M., Garcia, D., Diaz, A., & Blomberg, B. B. (2021) · Immunity & Ageing · doi:10.1186/s12979-021-00222-3 · Cited by 37

Rituximab in Systemic Lupus Erythematosus: Transient Effects on Autoimmunity Associated Lymphocyte Phenotypes and Implications for Immunogenicity

Faustini, F., Sippl, N., Stålesen, R., Chemin, K., Dunn, N., Fogdell‐Hahn, A., Gunnarsson, I., & Malmström, V. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.826152 · Cited by 41

Cellular Senescence in Immunity against Infections

Marrella, V., Facoetti, A., & Cassani, B. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911845 · Cited by 38

Gammaherpesvirus infection drives age-associated B cells toward pathogenicity in EAE and MS

Mouat, I. C., Allanach, J. R., Fettig, N. M., Fan, V., Girard, A. M., Shanina, I., Osborne, L. C., Vorobeychik, G., & Horwitz, M. S. (2022) · Science Advances · doi:10.1126/sciadv.ade6844 · Cited by 40

Adaptive immunity and atherosclerosis: aging at its crossroads

Snijckers, R., & Foks, A. C. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1350471 · Cited by 40

Cytosolic nucleic acid sensing as driver of critical illness: mechanisms and advances in therapy

Chen, Z., Behrendt, R., Wild, L., Schlee, M., & Bode, C. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02174-2 · Cited by 44

Immunoporosis: The hidden link between aging immune cells and bone fragility

Cheng, X., Chen, Y., Zhou, X., Gu, Q., Zhao, H., Wan, C., Chen, M., Yang, H., & Shi, Q. (2025) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2025.06.015 · Cited by 37

Soluble antigen arrays disarm antigen-specific B cells to promote lasting immune tolerance in experimental autoimmune encephalomyelitis

Hartwell, B. L., Pickens, C. J., Leon, M. A., Northrup, L., Christopher, M. A., Griffin, J. D., Martinez-Becerra, F. J., & Berkland, C. J. (2018) · Journal of Autoimmunity · doi:10.1016/j.jaut.2018.06.006 · Cited by 36

Basics of memory B‐cell responses: lessons from and for the real world

Wong, R., & Bhattacharya, D. (2018) · Immunology · doi:10.1111/imm.13019 · Cited by 36

Molecular pattern recognition in peripheral B cell tolerance: lessons from age-associated B cells

Johnson, J. L., Scholz, J. L., Marshak‐Rothstein, A., & Cancro, M. P. (2019) · Current Opinion in Immunology · doi:10.1016/j.coi.2019.07.008 · Cited by 36

Peripheral Helper T Cell Responses in Human Diseases

Yoshitomi, H. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.946786 · Cited by 35

Aging Increases Susceptibility to Ovarian Cancer Metastasis in Murine Allograft Models and Alters Immune Composition of Peritoneal Adipose Tissue

Loughran, E. A., Leonard, A. K., Hilliard, T. S., Phan, R., Yemc, M. G., Harper, E. I., Sheedy, E. F., Klymenko, Y., Asem, M., Liu, Y., et al. (2018) · Neoplasia · doi:10.1016/j.neo.2018.03.007 · Cited by 36

Contribution of viral and bacterial infections to senescence and immunosenescence

Reyes, A., Ortiz, G., Duarte, L. F., Fernández, C., Hernández‐Armengol, R., Palacios, P. A., Prado, Y., Andrade, C. A., Rodríguez‐Guilarte, L., Kalergis, A. M., et al. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1229098 · Cited by 38

Innate-like B cell subsets during immune responses: Beyond antibody production

Romero‐Ramírez, S., Navarro-Hernández, I. C., Cervantes‐Díaz, R., Sosa‐Hernández, V. A., Acevedo‐Ochoa, E., Kleinberg-Bid, A., Valle‐Rios, R., Meza-Sánchez, D. E., Hernández‐Hernández, J. M., & Maravillas‐Montero, J. L. (2018) · Journal of Leukocyte Biology · doi:10.1002/jlb.mr0618-227r · Cited by 36

Compartmentalized effects of aging on group 2 innate lymphoid cell development and function

D’Souza, S. S., Shen, X., Fung, I. T. H., Ye, L., Kuentzel, M. L., Chittur, S. V., Furuya, Y., Siebel, C. W., Maillard, I. P., Metzger, D. W., et al. (2019) · Aging Cell · doi:10.1111/acel.13019 · Cited by 36

Mapping the Lineage Relationship between CXCR5+ and CXCR5− CD4+ T Cells in HIV-Infected Human Lymph Nodes

Alcazar, D. D., Wang, Y., He, C., Wendel, B. S., Estrada, P. M. D. R., Lin, J., Ablanedo‐Terrazas, Y., Malone, M. J., Hernandez, S. M., Frank, I., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.08.037 · Cited by 36

Murine gammaherpesvirus 68 infection protects lupus-prone mice from the development of autoimmunity

Larson, J. D., Thurman, J. M., Rubtsov, A. V., Claypool, D. J., Marrack, P., van Dyk, L. F., Torres, R. M., & Pelanda, R. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1203019109 · Cited by 35

Immunosenescence in renal transplantation

Seyda, M., Quante, M., Uehara, H., Slegtenhorst, B. R., Elkhal, A., & Tullius, S. G. (2015) · Current Opinion in Organ Transplantation · doi:10.1097/mot.0000000000000210 · Cited by 35

T-bethighCD21low B cells: the need to unify our understanding of a distinct B cell population in health and disease

Keller, B., & Warnatz, K. (2023) · Current Opinion in Immunology · doi:10.1016/j.coi.2023.102300 · Cited by 34

Evaluation of Cell-Specific Epigenetic Age Acceleration in People With Multiple Sclerosis

Maltby, V. E., Xavier, A., Ewing, E., Campagna, M. P., Sampangi, S., Scott, R. J., Butzkueven, H., Jokubaitis, V., Kular, L., Bos, S. D., et al. (2023) · Neurology · doi:10.1212/wnl.0000000000207489 · Cited by 37

Reversion of anergy signatures in clonal CD21low B cells of mixed cryoglobulinemia after clearance of HCV viremia

Padre, M. D., Todi, L., Mitrevski, M., Marrapodi, R., Colantuono, S., Fiorilli, M., Casato, M., & Visentini, M. (2017) · Blood · doi:10.1182/blood-2017-03-771238 · Cited by 34

Phenotypic characteristics of commonly used inbred mouse strains

Tam, W. Y., & Cheung, K. (2020) · Journal of Molecular Medicine · doi:10.1007/s00109-020-01953-4 · Cited by 36

Immunosuppression Considerations for Older Kidney Transplant Recipients

Cheungpasitporn, W., Lentine, K. L., Tan, J. C., Kaufmann, M., Çalışkan, Y., Bunnapradist, S., Lam, N. N., Schnitzler, M. A., & Axelrod, D. A. (2021) · Current Transplantation Reports · doi:10.1007/s40472-021-00321-6 · Cited by 35

A novel humanized cutaneous lupus erythematosus mouse model mediated by IL-21-induced age-associated B cells

Zhou, S., Li, Q., Zhou, S., Zhao, M., Lu, L., Wu, H., & Lu, Q. (2021) · Journal of Autoimmunity · doi:10.1016/j.jaut.2021.102686 · Cited by 33

Latent gammaherpesvirus exacerbates arthritis through modification of age-associated B cells

Mouat, I. C., Morse, Z. J., Shanina, I., Brown, K. L., & Horwitz, M. S. (2021) · eLife · doi:10.7554/elife.67024 · Cited by 33

Age-Related Cognitive Decline and Dementia: Interface of Microbiome–Immune–Neuronal Interactions

Prajapati, S. K., Jain, S., & Yadav, H. (2025) · The Journals of Gerontology Series A · doi:10.1093/gerona/glaf038 · Cited by 37

Age-associated B Cells Appear in Patients with Granulomatous Lung Diseases

Phalke, S., Aviszus, K., Rubtsova, K., Rubtsov, A. V., Barkes, B. Q., Powers, L. S., Warner, B., Crooks, J., Kappler, J. W., Pérez, E. R. F., et al. (2020) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201911-2151oc · Cited by 32

The role of B cells in immune cell activation in polycystic ovary syndrome

Ascani, A., Torstensson, S., Risal, S., Lu, H., Eriksson, G., Li, C., Teschl, S., Menezes, J., Sándor, K., Ohlsson, C., et al. (2023) · eLife · doi:10.7554/elife.86454 · Cited by 32

Inflammation and immunomodulation in central nervous system injury – B cells as a novel therapeutic opportunity

Maheshwari, S., Dwyer, L., & Sîrbulescu, R. F. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106077 · Cited by 34

Aging impairs murine B cell differentiation and function in primary and secondary lymphoid tissues.

Frasca, D., & Blomberg, B. B. (2011) · Europe PMC (PubMed Central) · Cited by 31

Nodal marginal zone B cells in mice: a novel subset with dormant self-reactivity

Palm, A.-K. E., Hawerkamp, H. C., & Kleinau, S. (2016) · Scientific Reports · doi:10.1038/srep27687 · Cited by 33

Potential functions of atypical memory B cells in Plasmodium-exposed individuals

Braddom, A. E., Batugedara, G., Bol, S. M., & Bunnik, E. M. (2020) · International Journal for Parasitology · doi:10.1016/j.ijpara.2020.08.003 · Cited by 31

Transcriptome and IgH Repertoire Analyses Show That CD11chi B Cells Are a Distinct Population With Similarity to B Cells Arising in Autoimmunity and Infection

Maul, R. W., Catalina, M. D., Kumar, V. V., Bachali, P., Grammer, A. C., Wang, S., Yang, W. W., Hasni, S., Ettinger, R., Lipsky, P. E., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.649458 · Cited by 32

Age/autoimmunity-associated B cells in inflammatory arthritis: An emerging therapeutic target

Li, Z., Cai, M.-L., Qin, Y., & Chen, Z. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1103307 · Cited by 31

Immune aging and infectious diseases

Chen, R., Zou, J., Chen, J., Wang, L., Kang, R., & Tang, D. (2024) · Chinese Medical Journal · doi:10.1097/cm9.0000000000003410 · Cited by 35

Cellular senescence is a key mediator of lung aging and susceptibility to infection

Torrance, B. L., & Haynes, L. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1006710 · Cited by 28

Effect of Gut Microbiota-Mediated Tryptophan Metabolism on Inflammaging in Frailty and Sarcopenia

Xu, Y., Mao, T., Wang, Y., Qi, X., Zhao, W.-J., Chen, H., Zhang, C., & Li, X. (2024) · The Journals of Gerontology Series A · doi:10.1093/gerona/glae044 · Cited by 31

Immunosenescence promotes cancer development: from mechanisms to treatment strategies

Wang, L., & Tang, D. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-025-02082-6 · Cited by 32

Dysregulation of humoral immunity in chronic infection

Cooper, L., & Good‐Jacobson, K. L. (2020) · Immunology and Cell Biology · doi:10.1111/imcb.12338 · Cited by 29

Monoallelic IRF5 deficiency in B cells prevents murine lupus

Pellerin, A., Yasuda, K., Cohen‐Bucay, A., Sandra, V., Shukla, P., Horne, B., Nündel, K., Viglianti, G. A., Xie, Y., Klein, U., et al. (2021) · JCI Insight · doi:10.1172/jci.insight.141395 · Cited by 29

Effect of polysaccharides from a Korean ginseng berry on the immunosenescence of aged mice

Kim, M., Yi, Y., Kim, J., Han, S. Y., Kim, S. H., Seo, D. B., Cho, J. Y., & Shin, S. S. (2017) · Journal of Ginseng Research · doi:10.1016/j.jgr.2017.04.014 · Cited by 30

BAFF system expression in double negative 2, activated naïve and activated memory B cells in systemic lupus erythematosus

Alvarez‐Gómez, J. A., Salazar‐Camarena, D. C., Román-Fernández, I. V., Ortiz‐Lazareno, P. C., Cruz, Á., Muñóz-Valle, J. F., Marín‐Rosales, M., Espinoza‐García, N., Sagrero‐Fabela, N., & Palafox‐Sánchez, C. A. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1235937 · Cited by 29

Correlation of Professional Antigen‐Presenting Tbet + CD11c + B Cells With Bone Destruction in Untreated Rheumatoid Arthritis

McGrath, S., Grimstad, K., Thorarinsdottir, K., Forslind, K., Glinatsi, D., Agelii, M. L., Aranburu, A., Sundell, T., Jonsson, C. A., Camponeschi, A., et al. (2024) · Arthritis & Rheumatology · doi:10.1002/art.42857 · Cited by 29

The immune landscape of murine skeletal muscle regeneration and aging

Sousa, N. S., Bica, M., Brás, M. F., Sousa, A. C., Antunes, I. B., Encarnação, I. A., Costa, T. M., Martins, I. B., Barbosa‐Morais, N. L., Sousa‐Victor, P., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114975 · Cited by 30

Immunoregulation by antibody secreting cells in inflammation, infection, and cancer

McGettigan, S. E., & Debes, G. F. (2021) · Immunological Reviews · doi:10.1111/imr.12991 · Cited by 31

Aging reshapes the adaptive immune system from healer to saboteur

Delgado-Pulido, S., Yousefzadeh, M. J., & Mittelbrunn, M. (2025) · Nature Aging · doi:10.1038/s43587-025-00906-1 · Cited by 29

The properties of the unique age-associated B cell subset reveal a shift in strategy of immune response with age

Swain, S. L., Kugler‐Umana, O., Kuang, Y., & Zhang, W. (2017) · Cellular Immunology · doi:10.1016/j.cellimm.2017.05.009 · Cited by 27

Regnase-1 is essential for B cell homeostasis to prevent immunopathology

Bhat, N., Virgen‐Slane, R., Ramezani-Rad, P., Leung, C. R., Chen, C., Balsells, D., Shukla, A., Kao, E., Apgar, J. R., Fu, M., et al. (2021) · The Journal of Experimental Medicine · doi:10.1084/jem.20200971 · Cited by 27

Double Negative (DN) B cells: A connecting bridge between rheumatic diseases and COVID-19?

Sachinidis, A., & Garyfallos, A. (2021) · Mediterranean Journal of Rheumatology · doi:10.31138/mjr.32.3.192 · Cited by 29

Uncontrolled CD21low age-associated and B1 B cell accumulation caused by failure of an EGR2/3 tolerance checkpoint

Masle‐Farquhar, E., Peters, T. J., Miosge, L. A., Parish, I. A., Weigel, C., Oakes, C. C., Reed, J. H., & Goodnow, C. C. (2022) · Cell Reports · doi:10.1016/j.celrep.2021.110259 · Cited by 27

CD28null T cells in aging and diseases: From biology to assessment and intervention

Guan, Y., Cao, M., Wu, X., Yan, J., Hao, Y., & Zhang, C. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.111807 · Cited by 27

B and T Cell Immunity in Tissues and Across the Ages

Booth, J. S., & Toapanta, F. R. (2021) · Vaccines · doi:10.3390/vaccines9010024 · Cited by 30

RNASE2 Mediates Age-Associated B Cell Expansion Through Monocyte Derived IL-10 in Patients With Systemic Lupus Erythematosus

Zhu, Y., Tang, X., Xu, Y., Wu, S., Liu, W., Geng, L., Ma, X., Tsao, B. P., Feng, X., & Sun, L. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.752189 · Cited by 25

cis interaction of CD153 with TCR/CD3 is crucial for the pathogenic activation of senescence-associated T cells

Fukushima, Y., Sakamoto, K., Matsuda, M., Yoshikai, Y., Yagita∥, H., Kitamura, D., Chihara, M., Minato, N., & Hattori, M. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111373 · Cited by 28

Amelioration of Autoimmunity in a Lupus Mouse Model by Modulation of T‐Bet –Promoted Energy Metabolism in Pathogenic Age/ Autoimmune‐Associated B Cells

Han, X., Gu, S., Hong, S., Jiang, Y., Zhang, J., Yao, C., Yin, Z., Ye, Z., Ding, H., Chen, S., et al. (2022) · Arthritis & Rheumatology · doi:10.1002/art.42433 · Cited by 29

Potential importance of B cells in aging and aging-associated neurodegenerative diseases

Biragyn, A., Aliseychik, M., & Rogaev, E. (2017) · Seminars in Immunopathology · doi:10.1007/s00281-016-0615-8 · Cited by 25

The role of autoantibodies in bridging obesity, aging, and immunosenescence

Valentino, T. R., Chen, N., Makhijani, P., Khan, S. M., Winer, S., Revelo, X. S., & Winer, D. A. (2024) · Immunity & Ageing · doi:10.1186/s12979-024-00489-2 · Cited by 27

Transient hepatic reconstitution of trophic factors enhances aged immunity

Friedrich, M., Pham, J., Tian, J., Chen, H., Huang, J., Kehl, N., Liu, S., Lash, B., Chen, F., Wang, X., et al. (2025) · Nature · doi:10.1038/s41586-025-09873-4 · Cited by 29

CD19 + CD21lo/neg cells are increased in systemic sclerosis-associated interstitial lung disease

Wilfong, E. M., Vowell, K. N., Bunn, K. E., Rizzi, E. M., Annapureddy, N., Dudenhofer, R. B., Barnado, A., Bonami, R. H., Johnson, J. E., Crofford, L. J., et al. (2021) · Clinical and Experimental Medicine · doi:10.1007/s10238-021-00745-5 · Cited by 25

Upregulated Fcrl5 disrupts B cell anergy and causes autoimmune disease

Ono, C., Tanaka, S., Myouzen, K., Iwasaki, T., Ueda, M. T., Oda, Y., Yamamoto, K., Kochi, Y., & Baba, Y. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1276014 · Cited by 25

T-bet+ Memory B Cells Link to Local Cross-Reactive IgG upon Human Rhinovirus Infection

Eccles, J. D., Turner, R. B., Kirk, N. A., Muehling, L. M., Borish, L., Steinke, J. W., Payne, S. C., Wright, P. W., Thacker, D. F., Lahtinen, S. J., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2019.12.027 · Cited by 25

Malaria exposure drives both cognate and bystander human B cells to adopt an atypical phenotype

Aye, R., Sutton, H. J., Nduati, E. W., Kai, O. K., Mwacharo, J., Musyoki, J., Otieno, E. G., Wambua, J., Bejon, P., Cockburn, I. A., et al. (2020) · European Journal of Immunology · doi:10.1002/eji.201948473 · Cited by 25

B Cells Dynamic in Aging and the Implications of Nutritional Regulation

Yu, Y., Lu, C., Yu, W., Lei, Y., Sun, S., Liu, P., Bai, F., Chen, Y., & Chen, J. (2024) · Nutrients · doi:10.3390/nu16040487 · Cited by 29

Critical roles of chronic BCR signaling in the differentiation of anergic B cells into age-associated B cells in aging and autoimmunity

Imabayashi, K., Yada, Y., Kawata, K., Yoshimura, M., Iwasaki, T., Baba, A., Harada, A., Akashi, K., Niiro, H., & Baba, Y. (2025) · Science Advances · doi:10.1126/sciadv.adt8199 · Cited by 28

Mechanistic insights and biomarker discovery in immune cell aging and age-associated diseases

Upadhyay, P., Suhail, A., Khanal, P., & Kumar, S. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1637191 · Cited by 24

Genetic Interaction between Lyn, Ets1, and Btk in the Control of Antibody Levels

Mayeux, J., Skaug, B. A., Luo, W., Russell, L., John, S. A., Saelee, P., Abbasi, H., Li, Q., Garrett‐Sinha, L. A., & Satterthwaite, A. B. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1500165 · Cited by 24

Age-associated B cell infiltration in salivary glands represents a hallmark of Sjögren’s-like disease in aging mice

Bagavant, H., Durślewicz, J., Pyclik, M. J., Makuch, M., Papinska, J. A., & Deshmukh, U. S. (2024) · GeroScience · doi:10.1007/s11357-024-01159-3 · Cited by 23

Aging Leukocytes and the Inflammatory Microenvironment of the Adipose Tissue

Dahlquist, K. J. V., & Camell, C. D. (2021) · Diabetes · doi:10.2337/dbi21-0013 · Cited by 25

Enhanced auto-antibody production and Mott cell formation in FcμR-deficient autoimmune mice

Honjo, K., Kubagawa, Y., Suzuki, Y., Takagi, M., Ohno, H., Bucy, R. P., Izui, S., & Kubagawa, H. (2014) · International Immunology · doi:10.1093/intimm/dxu070 · Cited by 23

Early derivation of IgM memory cells and bone marrow plasmablasts

Papillion, A. M., Kenderes, K. J., Yates, J. L., & Winslow, G. M. (2017) · PLoS ONE · doi:10.1371/journal.pone.0178853 · Cited by 23

Sensory neurons regulate stimulus-dependent humoral immunity in mouse models of bacterial infection and asthma

Aguilar, D., Zhu, F., Millet, A., Millet, N., Germano, P. M., Pisegna, J. R., Akbari, O., Doherty, T. A., Swidergall, M., & Jendzjowsky, N. G. (2024) · Nature Communications · doi:10.1038/s41467-024-53269-3 · Cited by 23

Immunosenescence in autoimmune diseases

Hu, H., Zhang, G., Chen, T., Liu, Y., Meng, L., Holmdahl, R., Dai, L., & Zhao, Y. C. (2025) · Autoimmunity Reviews · doi:10.1016/j.autrev.2025.103805 · Cited by 30

Changes in T and B cell subsets in end stage renal disease patients before and after kidney transplantation

Wang, L., Rondaan, C., de Joode, A. A. E., Raveling‐Eelsing, E., Bos, N. A., & Westra, J. (2021) · Immunity & Ageing · doi:10.1186/s12979-021-00254-9 · Cited by 23

Marginal Zone B-Cell Populations and Their Regulatory Potential in the Context of HIV and Other Chronic Inflammatory Conditions

Doyon-Laliberté, K., Aranguren, M., Poudrier, J., & Roger, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23063372 · Cited by 23

Age-associated B cells: are they the key to understanding why autoimmune diseases are more prevalent in women?

Rubtsova, K., Marrack, P., & Rubtsov, A. V. (2011) · Expert Review of Clinical Immunology · doi:10.1586/eci.11.83 · Cited by 22

In aged mice, low surrogate light chain promotes pro‐ B ‐cell apoptotic resistance, compromises the P re BCR checkpoint, and favors generation of autoreactive, phosphorylcholine‐specific B cells

Ratliff, M., Alter, S., McAvoy, K., Frasca, D., Wright, J. A., Zinkel, S. S., Khan, W. N., Blomberg, B. B., & Riley, R. L. (2015) · Aging Cell · doi:10.1111/acel.12302 · Cited by 22

The Pre‐B Cell Receptor; Selecting for or against Autoreactivity

Almqvist, N., & Mårtensson, I. (2012) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.2012.02751.x · Cited by 22

Immunosenescence and age-related immune cells: causes of age-related diseases

Kim, N., Sim, S.-J., Han, H.-G., Yoon, J.-H., & Han, Y. (2024) · Archives of Pharmacal Research · doi:10.1007/s12272-024-01529-7 · Cited by 22

B Cell Infection and Activation by Rabies Virus-Based Vaccines

Lytle, A. G., Norton, J. E., Dorfmeier, C. L., Shen, S., & McGettigan, J. P. (2013) · Journal of Virology · doi:10.1128/jvi.00800-13 · Cited by 21

Older adults: panoramic view on the COVID-19 vaccination

Andryukov, B. G., & Besednova, N. N. (2021) · AIMS Public Health · doi:10.3934/publichealth.2021030 · Cited by 23

Physiology of Aging

Dharmarajan, T. S. (2021) · Springer eBooks · doi:10.1007/978-3-030-30192-7_5 · Cited by 25

Interferon-γ signal drives differentiation of T-bethi atypical memory B cells into plasma cells following Plasmodium vivax infection

Kochayoo, P., Thawornpan, P., Wangriatisak, K., Changrob, S., Leepiyasakulchai, C., Khowawisetsut, L., Adams, J. H., & Chootong, P. (2022) · Scientific Reports · doi:10.1038/s41598-022-08976-6 · Cited by 21

PEGylated Gold Nanoparticles Target Age-Associated B Cells In Vivo

Hočevar, S., Puddinu, V., Haeni, L., Petri‐Fink, A., Wagner, J. A., Alvarez, M., Clift, M. J. D., & Bourquin, C. (2022) · ACS Nano · doi:10.1021/acsnano.2c04871 · Cited by 21

Bystanders or not? Microglia and lymphocytes in aging and stroke

Chauhan, A., & Nguyen, J. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.360345 · Cited by 21

Single-cell landscape analysis unravels molecular programming of the human B cell compartment in chronic GVHD

Poe, J. C., Fang, J., Zhang, D., Lee, M. R., DiCioccio, R. A., Su, H., Qin, X., Zhang, J. Y., Visentin, J., Bracken, S. J., et al. (2023) · JCI Insight · doi:10.1172/jci.insight.169732 · Cited by 21

Germinal center versus extrafollicular responses in systemic autoimmunity: Who turns the blade on self?

He, Y., & Vinuesa, C. G. (2024) · Advances in immunology · doi:10.1016/bs.ai.2024.02.002 · Cited by 23

IMMUNOBIOLOGY A B-cell subset uniquely responsive to innate stimuli accumulates in aged mice

Hao, Y., Naradikian, M. S., Scholz, J. L., & Cancro, M. P. (2016)

A B cell subset uniquely responsive to innate stimuli accumulates in aged mice (45.7)

Hao, Y., O'Neill, P., Naradikian, M. S., Scholz, J. L., & Cancro, M. P. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.186.supp.45.7 · Cited by 27

Coming of age: the formation and function of age-associated B cells

Rui, K., Che, N., Ma, K., Zou, H., Xiao, F., & Lu, L. (2024) · Cellular and Molecular Immunology · doi:10.1038/s41423-024-01143-z · Cited by 10

Accumulation of a unique mature B cell population in aged mice. (132.2)

Hao, Y., O’Neill, P., & Cancro, M. P. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.184.supp.132.2

Aging effects on T-bet expression in human B cell subsets

Frasca, D., Diaz, A., Romero, M., D’Eramo, F., & Blomberg, B. B. (2017) · Cellular Immunology · doi:10.1016/j.cellimm.2017.04.007 · Cited by 63