The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Outcome of AL amyloidosis after high-dose melphalan and autologous stem cell transplantation: long-term results in a series of 421 patients
Open accessAbstract
Previous studies have suggested that, in patients with AL amyloidosis treated with high-dose melphalan and autologous stem-cell transplantation (HDM/SCT), the greatest benefit is seen in those patients achieving a hematologic complete response (CR). We analyzed a series of 421 consecutive patients treated with HDM/SCT at a single referral center and compared outcomes for patients with and without CR. Treatment-related mortality was 11.4% overall (5.6% in the last 5 years). By intention-to-treat analysis, the CR rate was 34% and the median event-free survival (EFS) and overall survival (OS) were 2.6 and 6.3 years, respectively. Eighty-one patients died within the first year after HDM/SCT and were not evaluable for hematologic and organ response. Of 340 evaluable patients, 43% achieved CR and 78% of them experienced an organ response. For CR patients, median EFS and OS were 8.3 and 13.2 years, respectively. Among the 195 patients who did not obtain CR, 52% achieved an organ response, and their median EFS and OS were 2 and 5.9 years, respectively. Thus, treatment of selected AL patients with HDM/SCT resulted in a high organ response rate and long OS, even for those patients who did not achieve CR.
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Self-citationHigh-Dose Melphalan versus Melphalan plus Dexamethasone for AL Amyloidosis
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Cited by
Kittleson, M. M., Ruberg, F. L., Ambardekar, A. V., Brannagan, T. H., Cheng, R. K., Clarke, J. O., Dember, L. M., Frantz, J. G., Hershberger, R. E., Maurer, M. S., et al. (2023) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2022.11.022 · Cited by 640
Self-citationAmyloidosis of the gastrointestinal tract: a 13-year, single-center, referral experience
Cowan, A. J., Skinner, M., Seldin, D. C., Berk, J. L., Lichtenstein, D. R., O'Hara, C. J., Doros, G., & Sanchorawala, V. (2013) · Haematologica · doi:10.3324/haematol.2012.068155 · Cited by 206
Self-citationGordillo, C. A., Parmar, S., Blanco, M., Delille, E. M., Assal, A., Mapara, M., & Reshef, R. (2021) · Annals of Hematology · doi:10.1007/s00277-020-04378-8 · Cited by 29
Afrough, A., Saliba, R. M., Hamdi, A., El Fakih, R., Varma, A., Dinh, Y. T., Rondon, G., Cornelison, A. M., Shah, N. D., Bashir, Q., et al. (2015) · Biology of Blood and Marrow Transplantation · doi:10.1016/j.bbmt.2015.03.025 · Cited by 6
Metadata
- Authors
- Cibeira, M. T., Sanchorawala, V., Seldin, D. C., Quillen, K., Berk, J. L., Dember, L. M., Segal, A., Ruberg, F., Meier-Ewert, H., Andrea, N. T., Sloan, J. M., Finn, K. T., Doros, G., Blade, J., & Skinner, M.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2011-10-20
- Volume
- 118
- Issue
- 16
- Pages
- 4346-4352
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W1999473831
- Cited by
- 289
- References
- 27
- FWCI
- 10.23
- Type
- journal article
- Language
- en
- Open access
- green
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- Cibeira, M. T., Sanchorawala, V., Seldin, D. C., Quillen, K., Berk, J. L., Dember, L. M., Segal, A., Ruberg, F., Meier-Ewert, H., Andrea, N. T., Sloan, J. M., Finn, K. T., Doros, G., Blade, J., & Skinner, M. (2011). Outcome of AL amyloidosis after high-dose melphalan and autologous stem cell transplantation: long-term results in a series of 421 patients. Blood. https://doi.org/10.1182/blood-2011-01-330738
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